无乳链球菌毒力基因与耐药性的相关性研究进展

doi:10.16431/j.cnki.1671-7236.2021.01.041

Abstract

Abstract: Mastitis,which is the most common disease in dairy cows production,can cause inflammation and swelling in the mammary glands of cows,and significantly reduce the milk production.As a multi-factor disease,the reason for mastitis is very complicated.Mastitis is mainly affected by feed contamination,pathogenic bacteria infection,and environmental factors.As the main pathogenic bacteria of mastitis,Streptococcus agalactiae often induces local inflammation of breast tissue.With the increase of the separation rate of Streptococcus agalactiae and the abuse of antibacterial drugs,the resistance of Streptococcus agalactiae to antibacterial drugs gradually increases,which brings certain difficulties to clinical treatment.Additionally,Streptococcus agalactiae can colonize the host,and then damage the immune system of host,and its own virulence factors also can cause disease of host body.With the deepening of relevant researches,it has found that virulence and drug resistance are interrelated with each other.The virulence is affected by the increased drug resistance with different ways,indicating that there is a certain correlation between drug resistance and virulence factors.The authors reviewed research progress of the correlation between Streptococcus and other bacterial virulence genes and drug resistance at home and abroad.The virulence mechanism and virulence genes of Streptococcus agalactiae were analyzed from the perspectives of virulence factors and drug resistance.Besides,the drug resistance of Streptococcus agalactiae in different regions in the past 5 years was recorded.The relationship between Streptococcus virulence and drug resistance was reviewed from the perspectives of bacterial species,environment,and related mechanism,so as to provide theoretical reference for the reasonable selection of antibacterial agents for clinical symptoms induced by Streptococcus agalactiae and relevant researches of virulence genes and drug resistance.

Key words: Streptococcus agalactiae; virulence factor; drug resistance; mechanism; antibiotic

CLC Number:

S815

FAN Xue, SHAO Wei, ZHAO Yankun, DU Xiaohui, CHEN He, WANG Fulan. Research Progress on the Correlation Between Virulence Genes and Drug Resistance of Streptococcus agalactiae[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(1): 375-384.

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Research Progress on the Correlation Between Virulence Genes and Drug Resistance of Streptococcus agalactiae

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