岩藻多糖的生理功能及其在动物生产中的应用

doi:10.16431/j.cnki.1671-7236.2020.08.008

Abstract

Abstract: Fucoidan is a natural heteropolysaccharide,it is rich in natural resources,safe and non-toxic,it has a variety of physiological functions.Fucoidan can remove excess free radicals in the body,activate the antioxidant enzyme system,inhibit the signal transduction of oxidative stress pathways to exert antioxidant function,improve the body's immunity by inhibiting the production of inflammatory factors in the body,inhibiting the inflammatory pathway,promoting antibody expression,and improving the body's non-specific immunity,promote the apoptosis of cancer cells,and inhibit angiogenesis and improve the body's immunity to play an anti-tumor effect.Fucoidan also has various biological functions such as bacteriostasis,anti-virus and anti-thrombosis.Animal experiment shows that fucoidan can reduce the feed-to-gain ratio of piglets and improve the digestibility of nutrients,increase the total feed intake,total weight gain and feed conversion rate of chicks,increase significantly the weight,growth rate and PER of wild pheasants in South Asia,increase chicken's weight and breast muscle weight,improve the antioxidant capacity of pork,reduce intestinal inflammation and edema,increase intestinal villi height,improve intestinal flora balance,and adjust glucose and lipid metabolism,reduce body fat content.This article reviews the physical and chemical properties,physiological functions,and application status of fucoidan in animal production,in order to provide a theoretical basis for the application of fucoidan in animal production.

Key words: fucoidan; antioxidant; immunity; antitumor; animal production

CLC Number:

MA Yujing, YANG Ling, HE Rongxiang, HE Jianhua. Physiological Functions of Fucoidan and Its Application in Animal Production[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(8): 2404-2412.

References

[1] ABDUL R P,MUHAMMAD M,IHSAN U H,et al.In vitro and in vivo evaluation of anti-arthritic,antioxidant efficacy of fucoidan from Undaria pinnati-fida (Harvey) suringar[J].International Journal of Biological Macromolecules,2017,97:468-480.
[2] CATARIAN O,SARA G,NUNO M N,et al.Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo[J].Carbohydrate Polymers,2019,223:1-10.
[3] SUBRAMANIAN P,MANOHARAN V,PERIYANNAN R,et al.Antibacterial efficacy of a fucoidan fraction (Fu-F2) extracted from Sargassum polycystum[J].International Journal of Biological Macromolecules,2019,125:485-495.
[4] IRVINE N,DANIEL N,MAHESHKUMAR P P,et al.In vitro induction of endoplasmic reticulum stress in human cervical adenocarcinoma HeLa cells by fucoidan[J].International Journal of Biological Macromolecules,2019,137:844-852.
[5] 刘颖,张敏,吴茜茜,等.岩藻多糖的研究进展[J].食品与发酵工业,2011,37(6):146-151. LIU Y,ZHANG M,WU Q Q,et al.Advances on fucoidan[J].Food and Fermentation Industries,2011,37(6):146-151.(in Chinese)
[6] 刘冰月,刘学,邬凤娟,等.羊栖菜岩藻多糖的提取工艺优化及保湿性能[J].日用化学工业,2017,47(7):398-402. LIU B Y,LIU X,WU F J,et al.Optimization of process technological conditions for obtaining fucoidan from Sargassum fusiforme and detection of its moisturizing performance[J].China Surfactant Detergent & Cosmetics,2017,47(7):398-402.(in Chinese)
[7] SHEN P L,YIN Z M,QU G Y,et al.Fucoidan and its health benefits[J].Bioactive Seaweeds for Food Applications,2018,11:223-238.
[8] 闫征,李双石,于海龙,等.酸性电解水法制备褐藻糖胶的研究[J].食品工业,2019,40(2):47-50. YAN Z,LI S S,YU H L,et al.Extraction of fucoidan by using acid electrolyzed water[J].The Food Industry,2019,40(2):47-50.(in Chinese)
[9] LIU B Y,LIU X,WU F J,et al.Extraction process optimization and moisturizing performance of fucoidan from Sargassum fusiforme[J].Medicinal Plant,2018,9(3):21-24.
[10] ZHANG S P,WANG X,CHEN S H,et al.Study on the desalination of crude extract of fucoidan[A].International Confercence on Responsive Manufacturing-green Manufacturing[C].2010.
[11] 张柯柯,刘伟治,律倩倩.海洋微生物来源的岩藻多糖降解酶[J].微生物学通报,2018,45(9):2054-2062. ZHANG K K,LIU W Z,LYU Q Q.Fucoidan-degrading enzymes from marine microorganisms[J].Microbiology China,2018,45(9):2054-2062.(in Chinese)
[12] 艾正文,桂敏,于鹏,等.岩藻多糖结构对其功能的影响研究进展[J].食品工业科技,2019,40(9):346-350. AI Z W,GUI M,YU P,et al.Research progress on the effect of fucoidin structure on the its function[J].Science and Technology of Food Industry,2019,40(9):346-350.(in Chinese)
[13] JHELEN F,GIORGIO D A,VICKI-ANNE G,et al.Topical benefits of two fucoidan-rich extracts from marine macroalgae[J].Cosmetics,2015,2(2):66-81.
[14] 韩扬,汪淑晶.褐藻多糖及其衍生物的抗肿瘤作用[J].生命的化学,2019,39(4):673-680. HAN Y,WANG S J.The anti-tumor effect of brown algae polysaccharide and its derivatives[J].Chemistry of Life,2019,39(4):673-680.(in Chinese)
[15] 丛瑶,宋悦凡,汪秋宽.褐藻多糖硫酸酯降解及其产物活性研究进展[J].水产科学,2017,36(5):674-682. CONG Y,SONG Y F,WANG Q K.Advances on research of degradation of fucoidan and activities of its products[J].Fisheries Science,2017,36(5):674-682.(in Chinese)
[16] JONG-IL C,HYUN-JOO K.Preparation of low molecular weight fucoidan by gamma-irradiation and its anticancer activity[J].Carbohydrate Polymers,2013,97(2):358-362.
[17] 张加幸,苗钧魁,冷凯良.收获期内不同品种鲜海带中岩藻多糖含量、组成及其抗氧化活性研究[J].应用化工,2016,45(11):2186-2189. ZHNAG J X,MIAO J K,LENG K L.Study on the content and compose of fucoidan in different species fresh seaweeds and the antioxidant of their crude fucoidan[J].Applied Chemical Industry,2016,45(11):2186-2189.(in Chinese)
[18] YANG Q,YAGN R,LI M,et al.Effects of dietary fucoidan on the blood constituents,anti-oxidation and innate immunity of juvenile Yellow catfish (Pelteobagrus fulvidraco)[J].Fish & Shellfish Immunology,2014,41(2):264-270.
[19] WANG Y C,SUN W,ZHANG C Y,et al.Protective effect of sea cucumber (Acaudina molpadioides) fucoidan against ethanol-induced gastric damage[J].Food Chemistry,2012,133(4):1414-1419.
[20] 谌素华,王维民,蔡璐,等.马尾藻岩藻聚糖硫酸酯对高脂血症小鼠抗脂质过氧化的作用[J].现代食品科技,2015,31(9):38-44. SHEN S H,WANG W M,CAI L,et al.Anti-lipoperoxidation effects of Sargassum fucoidans in hyperlipi-demic mice[J].Modern Food Science and Technology,2015,31(9):38-44.(in Chinese)
[21] ZHAO X,WANG F J,XUE C H.The inhibitory effects of fucoidans from Laminaria japonica on oxidation of human low-density lipoproteins[J].Advanced Materials Research,2011,236-238:2067-2071.
[22] HOU Y,WANG J,JIN W H,et al.Degradation of Laminaria japonica fucoidan by hydrogen peroxide and antioxidant activities of the degradation products of different molecular weights[J].Carbohydrate Polymers,2012,87(1):153-159.
[23] TOMORI M,NAGAMINE T,MIYAMOTO T,et al.Evaluation of the immunomodulatory effects of fucoidan derived from Cladosiphon okamuranus Tokida in mice[J].Marine Drugs,2019,17(10):547-554.
[24] 王晓玲,陈曼华.岩藻多糖抑制小鼠心肌梗死后的心脏重构[J].基础医学与临床,2015,35(7):959-962. WANG X L,CHEN M H.Fucoidan inhibits cardiac remodeling after myocardial infarction in mice[J].Basic & Clinical Medicine,2015,35(7):959-962.(in Chinese)
[25] DELMA C R,THIRUGNANASAMBANDAN S,SRINIVASAN G P,et al.Fucoidan from marine brown algae attenuates pancreatic cancer progression by regulating p53-NFκB crosstalk[J].Phytochemistry,2019,167:112078.
[26] KAN J,HOOD M,BURNS C,et al.A Novel combination of wheat peptides and fucoidan attenuates ethanol-induced gastric mucosal damage through anti-oxidant,anti-inflammatory,and pro-survival mechanisms[J].Nutrients,2017,9(9):E978.
[27] ADNAN H G,NATOTTAM P S,SUJATA S,et al.Effect of dietary Sargassum wightii and its fucoidan-rich extract on growth,immunity,disease resistance and antimicrobial peptide gene expression in Labeo rohita[J].International Aquatic Research,2018,10(2):115-131.
[28] 凌绍梅,吴永沛,刘翼翔,等.低分子量岩藻聚糖制备工艺及其抗菌活性的研究[J].食品科技,2014,39(7):184-189. LING S M,WU Y P,LIU Y X,et al.Preparation technology of low-molecular-weight fucoidans and their antibacterial activity[J].Food Science and Technology,2014,39(7):184-189.(in Chinese)
[29] FENG H,YANG Y,YANG G,et al.Studies on antibacterial activity and antibacterial mechanism of a novel polysaccharide from Streptomyces virginia H03[J].Food Control,2010,21(9):1257-1262.
[30] LEE K Y,JEONG M R,CHOI S M,et al.Synergistic effect of fucoidan with antibiotics against oral pathogenic bacteria[J].Archives of Oral Biology,2013,58(5):482-492.
[31] 钱卓权,殷皓臻,黄晓林,等.三种海藻抑菌活性和抗氧化活性[J].浙江农业学报,2014,26(2):384-387. QIAN Z Q,YIN H Z,HUANG X L,et al.Antibacterial and antioxidant bioassay of three kinds of algae[J].Acta Agriculturae Zhejiangensis,2014,26(2):384-387.(in Chinese)
[32] SIVAGNANAVELMURUGAN M,KARTHIK R G,JUDE T B,et al.Effect of Sargassum wightii fucoidan on growth and disease resistance to vibrio parahaemolyticus in penaeus monodon post-larvae[J].Aquaculture Nutrition,2015,21(6):960-969.
[33] 陈海秀.海洋硫酸多糖抗菌活性研究及在肉类保鲜中的应用[D].厦门:集美大学,2016. CHEN H X.Study on Antimicrobial activity of marine sulfate polysaccharide and its application in meat preservation[D].Xiamen:Jimei University,2016.(in Chinese)
[34] HUANG C Y,KUO C H,LEE C H.Antibacterial and antioxidant capacities and attenuation of lipid accumulation in 3T3-L1 adipocytes by low-molecular-weight fucoidans prepared from compressional-puffing-pretreated Sargassum crassifolium[J].Marine drugs,2018,16(1):E24.
[35] YAN M D,LIN H Y,HWANG P A.The anti-tumor activity of brown seaweed oligo-fucoidan via lncRNA expression modulation in HepG2 cells[J].Cytotechnology,2019,71(1):363-374.
[36] ZHANG Z Y.Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways[J].PLoS One,2011,11(6):e27441.
[37] ZHANG Z Y,TERUYA K,YOSHIDA T,et al.Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells[J].Marine drugs,2013,11(1):81-98.
[38] 闫洪雪,孙占一,赵丽丽,等.岩藻多糖的抗癌活性研究进展[J].食品研究与开发,2018,39(24):197-203. YAN H X,SUN Z Y,ZHAO L L,et al.Research progress in the anticancer activity of fucoidan[J].Food Research and Development,2018,39(24):197-203.(in Chinese)
[39] CHEN H J,CONG Q F,DU Z Y,et al.Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling[J].Cancer Letters,2016,382(1):44-52.
[40] LEE K W,JEONG D Y,NA K.Doxorubicin loading fucoidan acetate nanoparticles for immune and chemotherapy in cancer treatment[J].Carbohydrate Polymers,2013,94(2):850-856.
[41] XUE M L,LIANG H,TANG Q J,et al.The protective and immunomodulatory effects of fucoidan against 7,12-dimethyl benz[a]anthracene-induced experimental mammary carcinogenesis through the PD1/PDL1 signaling pathway in rats[J].Nutrition and Cancer,2017,69(8):1234-1244.
[42] 刘萍,赵金标,耿正颖,等.日粮添加褐藻糖胶对断奶仔猪抗炎能力和肠道微生物多样性的影响[J].微生物学报,2019,59(4):700-710. LIU P,ZHAO J B,GENG Z Y,et al.Influence of dietary fucoidan on inflammatory response and intestinal microbial diversity in weaned pigs[J].Acta Microbiologica Sinica,2019,59(4):700-710.(in Chinese)
[43] MCALPINE P,CORMAC O,VARLEY P,et al.The effect of seaweed extract as an alternative to zinc oxide diets on growth performance,nutrient digestibility,and fecal score of weaned piglets[J].Journal of Animal Science,2012,90:224-226.
[44] SWEENEYA T,MEREDITHA H,VIGORS S,et al.Extracts of laminarin and laminarin/fucoidan from the marine macroalgal species Laminaria digitata improved growth rate and intestinal structure in young chicks,but does not influence Campylobacter jejuni colonisation[J].Animal Feed Science & Technology,2017,232:71-79.
[45] CUI H,WANG Z G,LIU J,et al.Effects of a highly purified fucoidan from Undaria pinnatifida on growth performance and intestine health status of gibel carp Carassius auratus gibelio[J].Aquaculture Nutrition,2020,26(1):47-59.
[46] SONY N M,ISHIKAWA M,HOSSAIN M S.et al.The effect of dietary fucoidan on growth,immune functions,blood characteristics and oxidative stress resistance of juvenile red sea bream,pagrus major[J].Fish Physiology and Biochemistry,2019,45(1):439-454.
[47] MIR I N,SAHU N P,PAL A K,et al.Synergistic effect of L-methionine and fucoidan rich extract in eliciting growth and non-specific immune response of Labeo rohita fingerlings against Aeromonas hydrophila[J].Aquaculture,2017,479:396-403.
[48] ZHANG Y,XU M,HU C,et al. Sargassum fusiforme fucoidan SP2 extends the lifespan of drosophila melanogaster by upregulating the Nrf2-mediated antioxidant signaling pathway[J].Oxidative Medicine and Cellular Longevity,2019,2019:8918914.
[49] LEAN Q Y,ERI R D,FITTON J H,et al.Fucoidan extracts ameliorate acute colitis[J].PLoS One,2015,10(6):e0128453.
[50] CHOI Y,HUSSEINDOUST A,GOEL A,et al.Effects of Ecklonia cava as fucoidan-rich algae on growth performance,nutrient digestibility,intestinal morphology and caecal microflora in weanling pigs[J].Asian-Australasian Journal of Animal Sciences,2016,30(1):64-70.
[51] 刘雪环,胡沙沙,王程,等.褐藻糖胶对大鼠肠缺血再灌注损伤的作用及潜在机制[J].中国病理生理杂志,2019,35(7):1296-1301. LIU X H,HU S S,WANG C,et al.Effect of fucoidan on intestinal ischemia-reperfusion injury in rats[J].Chinese Journal of Pathophysiology,2019,35(7):1296-1301.(in Chinese)
[52] HWANG P A,LIN H T V,LIN H Y,et al.Dietary supplementation with low-molecular-weight fucoidan enhances innate and adaptive immune responses and protects against mycoplasma pneumoniae antigen stimulation[J].Marine Drugs,2019,17(3):E175.
[53] 萨仁娜.海带岩藻聚糖分级纯化及对肉仔鸡巨噬细胞免疫调节的研究[D].北京:中国农业科学院,2008. SA R N.Isolation and purification of fucoidan from Laminaria japonica and its immunomodulatory activities on broiler macrophage[D].Beijing:Chinese Academy of Agricultural Sciences,2008.(in Chinese)
[54] MORONETY N C,OGRADY M N,ROBERTSON R C,et al.Influence of level and duration of feeding polysaccharide (laminarin and fucoidan) extracts from brown seaweed (Laminaria digitata) on quality indices of fresh pork[J].Meat Science,2015,99(99):132-141.
[55] MAIORANO G,STADNICKA K,TAVANIELLO S,et al.In ovo validation model to assess the efficacy of commercial prebiotics on broiler performance and oxidative stability of meat[J].Poultry Science,2017,96(2):511-518.
[56] DOCKAL M,HOELLRIEGL W,ZHANG Z,et al.Structural and functional characterization of fucoidan and its procoagulant effect in an ex vivo model of factorⅧ-inhibited guinea pigs[J].Blood,2011,118(21):2262.
[57] 廖敏,王维民,谌素华,等.马尾藻岩藻聚糖硫酸酯组成分析及抗血栓活性评价[J].食品科学,2017,38(19):189-194. LIAO M,WANG W M,CHEN S H,et al.Composition analysis and antithrombotic activity of fucoidan from Sargassum henslowianum C.agardh[J].Food Science,2017,38(19):189-194.(in Chinese)
[58] 龙腾腾.海地瓜硫酸多糖抑制脂肪细胞分化和改善胰岛素抵抗作用的研究[D].青岛:中国海洋大学,2013. LONG T T.Study of acaudina molpadioides sulfated polysaccharide's inhibition effects on the adipocytes differentiation and alleviating effects on insulin resistance[D].Qingdao:Ocean University of China,2013.(in Chinese)
[59] KIM M J,JEON J,LEE J S.Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation[J].Phytotherapy Research,2014,28(1):137-143.
[60] SUN T H,ZHANG X H,MIAO Y,et al.Studies on antiviral and immuno-regulation activity of low mole-cular weight fucoidan from Laminaria japonica[J].Journal of Ocean University of China,2018,17(3):705-711.

Physiological Functions of Fucoidan and Its Application in Animal Production

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