甘露寡糖对肠道健康和免疫的调控机制及其在畜禽生产中的应用

doi:10.16431/j.cnki.1671-7236.2020.02.014

Abstract

Abstract: In the past few decades,due to the abuse of feed antibiotics in animal husbandry,the normal intestinal flora of livestock and poultry has been destroyed and caused a series of problems such as intestinal bacterial resistance and environmental pollution,seriously damaged livestock and poultry intestinal health.At the same time,intensive farming has become the development direction of animal husbandry in recent years,and the scale of breeding is getting bigger and bigger.How to effectively improve the immunity of livestock and poultry has become the focus of research.A healthy intestinal tract is the basis for ensuring the healthy growth of livestock and poultry.Maintaining a healthy intestinal flora can effectively improve the immunity and disease resistance of the animal body.Mannan oligosaccharides is a new green feed additive.As a kind of functional oligosaccharide,it has the functions of improving intestinal health and improving immune response of livestock and poultry.In pig production,the addition of mannan oligosaccharides can improve the growth performance and immunity of weaned piglets.In poultry production,the addition of mannan oligosaccharides can improve the intestinal flora of poultry and improve production performance and meat quality.The article mainly introduces the structure and physicochemical properties of mannan oligosaccharides,improves intestinal health and immune regulation mechanism and its application in weaned piglets,finishing pigs,laying hens and broiler chickens.The paper summarizes the regulation mechanism and immune pathway of mannan oligosaccharides on intestinal health and immunity of livestock and poultry,and aims to provide theoretical basis for the in-depth study of manno oligosaccharides in intestinal health and immune regulation and its application in livestock and poultry breeding.

Key words: mannan oligosaccharide; immune regulation; intestinal health; mechanism; production performance

CLC Number:

S816.7

WANG Min, PENG Peiyuan, YANG Tai, DENG Pan, TIAN Kexiong. A Regulation Mechanism of Mannan Oligosaccharide on Intestinal Health and Immunity and Its Application in Livestock and Poultry Production[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(2): 433-441.

References

[1] SOHN K S,KIM M K,KIM J D,et al.The role of immunostimulants in monogastric animal and fish review[J].Asian Australasian Journal of Animal Sciences,2000,13(8):1178-1187.
[2] MUL A J,PERRY F G.The role of fructo-oligosaccharides in animal nutrition[A].Recent Advances in Animal Nutrition[C].1994.
[3] 李玉欣.毕赤酵母甘露寡糖对猪生产性能和免疫性能的影响[D].北京:中国农业大学,2015. LI Y X.Effect of Pichia guillermondii mannan oligosaccharide on growth performance and immune function in pigs[D].Beijing:China Agricultural University,2015.(in Chinese)
[4] HAJIAGHAPOUR M,REZAEIPOUR V.Comparison of two herbal essential oils,probiotic,and mannan-oligosaccharides on egg production,hatchability,serum metabolites,intestinal morphology,and microbiota activity of quail breeders[J].Livestock Science,2018,210:93-98.
[5] DUAN X D,CHEN D W,ZHENG P,et al.Effects of dietary mannan oligosaccharide supplementation on performance and immune response of sows and their offspring[J].Animal Feed Science and Technology,2016,218:17-25.
[6] VALPOTIĆ H,ZURA ZAJA I,SAMARDZIJA M,et al.Dietary supplementation with mannan oligosaccharide and clinoptilolite modulates innate and adaptive immune parameters of weaned pigs[J].Polish Journal of Veterinary Sciences,2018,21(1):83-93.
[7] BALLOU C E.A study of the immunochemistry of three yeast mannans[J].Journal of Biological Chemistry,1970,245(5):1197-1203.
[8] FLICKINGER E A,WOLF B W,GARLEB K A,et al.Glucose-based oligosaccharides exhibit different in vitro fermentation patterns and affect in vivo apparent nutrient digestibility and microbial populations in dogs[J].Journal of Nutrition,2000,130(5):1267-1273.
[9] GHASEMIAN M,JAHANIAN R.Dietary mannan-oligosaccharides supplementation could affect perfor-mance,imm-unocompetence,serum lipid metabolites,intestinal bacterial populations,and ileal nutrient digestibility in aged laying hens[J].Animal Feed Science and Technology,2016,213:81-89.
[10] BAURHOO B,PHILLIP L,RUIZFERIA C A.Effects of purified lignin and mannan oligosaccharides on intestinal integrity and microbial populations in the ceca and litter of broiler chickens[J].Poultry Science,2007,86(6):1070-1078.
[11] SANTOS F S D L,DONOGHUE A M,FARNELL M B,et al.Gastrointestinal maturation is accelerated in turkey poults supplemented with a mannan-oligosaccharide yeast extract (Alphamune)[J].Poultry Science,2007,86(5):921-930.
[12] OFEK I,MIRELMAN D,SHARON N.Adherence of Escherichia coli to human mucosal cells mediated by mannose receptors[J].Nature,1977,265:623-625.
[13] JAHANIAN E,MAHDAVI A H,ASGARY S,et al.Effect of dietary supplementation of mannano ligosaccharides on growth performance,ileal microbial counts,and jejunal morphology in broiler chicks exposed to aflatoxins[J].Livestock Science,2016,190:123-130.
[14] WEISS W P.Selenium sources for dairy cattle[J].Tri,2005,32:61-71.
[15] PAULINE M R,MARK R W,RAYMOND A P.Sugar-mediated ligand receptor interactions in the mimune system[J].Trends in Biotechology,2004,10(22):524-530.
[16] WU G J,TSAI G J.Chitooligosaccharides in combination with interferon-gamma increase nitric oxide production via nuclear factor-kappaB activation in murine RAW264.7 macrophages[J].Food and Chemical Toxicology,2007,45(2):250-258.
[17] ZHANG M J,LIU Y,SONG J H,et al.Characterization and functional analysis of a novel mannose-binding lectin from the swimming crab Portunus trituberculatus[J].Fish and Shellfish Immunology,2019,89:448-457.
[18] CZEREWATY M,TARNOWSKI M,SAFRANOW K,et al.Mannose binding lectin 2 gene polymorphisms in patients after renal transplantation with acute graft rejection[J].Transplant Immunology,2019,54:29-37.
[19] TORRECILLAS S,MONTERO,D,IZQUIERDO M.Improved health and growth of fish fed mannan oligosaccharides:Potential mode of action[J].Fish Shellfish Immunol,2014,36:525-544.
[20] NIKOLAKOPOULOU K,ZARKADIS I K.Molecular cloning and characterisation of two homologues of mannose-binding lectin in rainbow trout[J].Fish and Shellfish Immunology,2006,21:305-314.
[21] PATEL P K,HINDALA M,KOHLI B,et al.Divalent metal ions binding properties of goat serum mannose binding lectin[J].International Journal of Biological Macromolecules,2015,80:324-327.
[22] ISABELLA H I,AMANDA L R,KRISTIAN H,et al.Associations between complement pathways activity,mannose-binding lectin,and odds of unprovoked venous thromboembolism[J].Thrombosis Research,2018,169:50-56.
[23] TAKEDA K,KAISHO T,AKIRA S.Toll-like receptors[J].Annual Review of Immunology,2003,21(1):335.
[24] XU K D,ZHANG Z Y,TANG Z R,et al.A novel invertebrate Toll-like receptors is involved in TLR mediated signal pathway of thick shell mussel Mytilus coruscus[J].Developmental and Comparative Immunology,2019,97:11-19.
[25] ZHU Y T,ZHANG X,WANG S C,et al.Antimicrobial functions of EsLecH,a C-type lectin,via JNK pathway in the Chinese mitten crab,Eriocheir sinensis[J].Developmental and Comparative Immunology,2016,61:225-235.
[26] FLANNE RY S,BOWIE A G.The interleukin-1 receptor-associated kinases:Critical regulators of innate immune signalling[J].Biochemical Pharmacology,2010,80(12):1981-1991.
[27] ZHANG Z,SCHLUESENER H.Mammalian toll-like receptors:From endogenous ligands to tissue regeneration[J].Cellular and Molecular Life Sciences,2006,63(24):2901-2907.
[28] NERREN J R,HE H,GENOVESE K,et al.Expression of the avian-specific toll-like receptor 15 in chicken heterophils is mediated by Gram-negative and Gram-positive bacteria,but not TLR agonists[J].Veterinary Immunology and Immunopathology,2010,136(1-2):151-156.
[29] YILMAZ A,SHEN S,ADELSON D L,et al.Identification and sequence analysis of chicken Toll-like receptors[J].Immunogenetics,2005,56(10):743-753.
[30] KORDJAZY N,HAJ-MIRZAIAN A,HAJ-MIRZAIAN A,et al.Role of toll-like receptors in inflammatory bowel disease[J].Pharmacological Research,2018,129:205-215.
[31] CHANG G,KAI Z,TIANLE X,et al.Feeding a high-grain diet reduces the percentage of LPS clearance and enhances immune gene expression in goat liver[J].BMC Veterinary Research,2015,67:1-11.
[32] GARCIA T D,FERRIANI A B,JACOVACI F A,et al.Inclusion of live yeast and mannan-oligosaccharides in high grain-based diets for sheep:Ruminal parameters,inflammatory response and rumen morphology[J].PLoS One,2018,13(2):184-196.
[33] DOBROVOLSKAIA M A,VOGEL S N.Toll receptors,CD14,and macrophage activation and deactivation by LPS[J].Microbes and Infection,2002,4(9):903-914.
[34] WANG W,LI Z,HAN Q,et al.Dietary live yeast and mannan-oligosaccharide supplementation attenuate intestinal inflammation and barrier dysfunction induced by Escherichia coli in broilers[J].British Journal of Nutrition,2016,116(11):1878-1888.
[35] POURABEDIN M,CHEN Q,YANG M M,et al.Mannan and xylooligosaccharides modulate cecal microbiota and expression of inflammatory related cytokines and reduce caecal Salmonella enteritidis colonization in young chickens[J].FEMS Microbiology Ecology,2016,93(1):226.
[36] LU J T,QI C L,LIMBU S M,et al.Dietary mannan oligosaccharide (MOS) improves growth performance,antioxidant capacity,non-specific immunity and intestinal histology of juvenile Chinese mitten crabs (Eriocheir sinensis)[J].Aquaculture,2019,510(15):337-346.
[37] LIU X Y,CHEN S,YAN Q J,et al.Effect of Konjac mannan oligosaccharides on diphenoxylate-induced constipation in mice[J].Journal of Functional Foods,2019,57:399-407.
[38] CHENG Y F,DU M F,QIAO X,et al.Dietary mannan oligosaccharide improves growth performance,muscle oxidative status,and meat quality in broilers under cyclic heat stress[J].Journal of Thermal Biology,2018,75:106-111.
[39] ATTIA Y A,AL-KHALAIFAH H,IBRAHIM M S,et al.Blood hematological and biochemical constituents,a ntioxidant enzymes,immunity and lymphoid organs of broiler chicks supplemented with propolis,bee pollen and mannan oligosaccharides continuously or intermittently[J].Poultry Science,2017,96(12):4182-4192.
[40] CHOI S W,BENZIE I F F,COLLINS A R,et al.Vitamins C and E:Acute interactive effects on biomarkers of antioxidant defence and oxidative stress[J].Mutation Research,2004,551(1-2):109-117.
[41] OGNIK K,KRAUZE M.Dietary supplementation of mannanoligosaccharides to turkey hens on their growth performance and antioxidant status in the blood[J].South African Journal of Animal Science,2011,42(4):379-388.
[42] 李玉欣,张立梅,韩丹丹,等.毕赤酵母甘露寡糖对断奶仔猪生产性能肠道绒毛和细胞因子的影响[J].中国兽医杂志,2015,51(11):33-35. LI Y X,ZHANG L M,HAN D D,et al.Effects of Pichia guilliermondii oligosaccharide on growth performance,intestinal morphology and serunm cytokine of weanling piglets[J].Chinese Journal of Veterinary Medicine,2015,51(11):33-35.(in Chinese)
[43] 张继忠.甘露寡糖和复合酸化剂组合使用对八眉猪生长性能的影响[J].养猪,2015,3:43-44. ZHANG J Z.Effects of the combination of mannooligosaccharides and complex acidifiers on the growth performance of Bamei pigs[J].Swine Production,2015,3:43-44.(in Chinese)
[44] 周红丽,张石蕊,贺建华.甘露寡糖对断奶仔猪肠道菌群和抗体水平及生长性能的影响[J].湖南农业大学学报(自然科学版),2002,2:135-138. ZHOU H L,ZHANG S R,HE J H.Effects of mannan-oligosaccharide on intestinal microflora,antibody levels and performance of weaning piglets[J].Journal of Hunan Agricultural University (Natural Science Edition),2002,2:135-138.(in Chinese)
[45] GIANNENAS I,DOUKAS D,KARAMOUTSIOS A,et al.Effects of Enterococcus faecium,mannan oligosaccharide,benzoic acid and their mixture on growth performance,intestinal microbiota,intestinal morphology and blood lymphocyte subpopulations of fattening pigs[J].Animal Feed Science and Technology,2016,220:159-167.
[46] 苏成文,肖发沂,李义,等.小麦日粮中益生菌与甘露寡糖对保育猪生产性能及粪便微生物的影响[J].黑龙江畜牧兽医,2016,13:117-119. SU C W,XIAO F Q,LI Y,et al.Effects of probiotics and mannan oligosaccharides in the wheat diet on the productive performance and fecal microorganisms of nursing pigs[J].Heilongjiang Animal Husbandry and Veterinary Medicine,2016,13:117-119.(in Chinese)
[47] CZECH A,GRELA E R,MOKRZYCKA A,et al.Efficacy of mannanoligosaccharides additive to sows diets on colostrum,blood immunoglobulin content and production parameters of piglets[J].Polish Journal of Veterinary Sciences,2010,13(3):525-531.
[48] HALAS V,NOCHTA I.Mannan oligosaccharides in nursery pig nutrition and their potential mode of action[J].Animals,2012,2(2):261-274.
[49] JAHANIAN R,ASHNAGAR M.Effect of dietary supplementation of mannan-oligosaccharides on performance,blood metabolites,ileal nutrient digestibility,and gut microflora in Escherichia coli-challenged laying hens[J].Poultry Science,2015,94(9):2165-2172.
[50] 陈伟.饲粮中添加甘露寡糖对蛋鸡生产性能、免疫力、血脂代谢、肠道微生物区系和回肠养分消化率的影响[J].广东饲料,2016,25(5):51. CHEN W.Effects of adding mannan oligosaccharides in diet on production performance,immunity,lipid metabolism,intestinal microflora and ileal nutrient digestibility of laying hens[J].Guangdong Feed,2016,25(5):51.(in Chinese)
[51] 熊阿玲.日粮添加甘露寡糖对肉鸡生长性能及天然免疫相关基因表达的影响研究[D].南昌:江西农业大学,2014. XIONG A L.Studies on the effects of dietary supplementation of mannan oligosaccharide on the growth performance and innate immunity-associated gene expression in broiler chickens[D].Nanchang:Jiangxi Agricultural University,2014.(in Chinese)
[52] ZHANG Z Y,JIA G Q,ZUO J J,et al.Effects of constant and cyclic heat stress on muscle metabolism and meat quality of broiler breast fillet and thigh meat[J].Poultry Science,2012,91(11):2931-2937.
[53] KOOHMARAIE M,WHIPPLE G,CROUSE J D.Acceleration of postmortem tenderization in lamb and Brahman-cross beef carcasses through infusion of calcium chloride[J].Journal of Animal Science,1990,68(5):1278-1283.

A Regulation Mechanism of Mannan Oligosaccharide on Intestinal Health and Immunity and Its Application in Livestock and Poultry Production

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