猪繁殖与呼吸综合征病毒诱导的炎症反应及抗炎药物研究进展

doi:10.16431/j.cnki.1671-7236.2024.08.030

Abstract

Abstract: Porcine reproductive and respiratory syndrome (PRRS) is a global disease caused by Porcine reproductive and respiratory syndrome virus (PRRSV),which causes severe reproductive disorders in sows and respiratory distress in piglets.The severity of the disease caused by PRRSV infection is related to the viral load and the cytokines produced in the body.PRRSV activates inflammatory signaling pathways through structural and non-structural proteins encoded by itself,resulting in the release of a large number of cytokines and chemokines to induce inflammatory responses,but excessive inflammatory responses,especially cytokine storms,may lead to serious tissue damage and aggravate the disease.Therefore,inhibiting the inflammation caused by PRRSV may be the main strategy to effectively prevent and control PRRS.At present,the commonly used anti-inflammatory drugs include recombinant interferon,non-steroidal anti-inflammatory drugs (NSAID) and steroids,etc.Traditional Chinese medicine preparations have also been confirmed to have a certain therapeutic effect on PRRS.However,the conditions,degree and mechanism of inflammation induced by PRRSV infection and the role of anti-inflammatory drugs are not yet clear.The author intends to review the inflammatory response induced by PRRSV and its mechanism of action,as well as the development and application of related anti-inflammatory drugs,in order to provide new ideas for the prevention and control of PRRS.

Key words: Porcine reproductive and respiratory syndrome virus (PRRSV); inflammatory response; cytokines; anti-inflammatory drugs

CLC Number:

S852.65^＋1

QIAO Changhong, CHEN Jing, LUO Qin, LIU Baoling, HE Zhenwen, LIU Dingyu, CHEN Xiangyu, WANG Xiaohu, WANG Gang, BAI Aiquan, CAI Rujian. Advances in Inflammation Induced by Porcine Reproductive and Respiratory Syndrome Virus and Anti-inflammatory Drugs[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(8): 3528-3539.

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Advances in Inflammation Induced by Porcine Reproductive and Respiratory Syndrome Virus and Anti-inflammatory Drugs

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