国内外猪源产肠毒素大肠杆菌疫苗研究进展

doi:10.16431/j.cnki.1671-7236.2019.07.029

Abstract

Abstract:

As one of the most common diseases in large scale pig farms,piglet diarrhea has brought serious problems and enormous losses to swine industry worldwide.Enterotoxigenic Escherichia coli (ETEC) is the main pathogen of piglet diarrhea,adhesin and enterotoxin are main virulence factors of ETEC.ETEC colonizes the small intestinal epithelial cells via adhesin,then enterotoxin is secreted and causes a large amount of water and electrolytes filling the enteric cavity,resulting in piglets diarrhea.At present,vaccination is the most effective way of controlling ETEC diarrhea.However,the commercial ETEC vaccines can not provide efficient protection against ETEC infection and have the obvious regional restriction.Therefore,it is of great significance for developing a safe,efficient and broad-spectrum ETEC vaccine.Now,many new experimental ETEC vaccines have been reported which mainly focused on the adhesin and enterotoxin.New type of ETEC vaccines with different advantages and good immune protective effect (such as subunit vaccine,ghost vaccine,plants vaccine and outer membrane vesicles vaccines) have been also developed by domestic and foreign researchers.In this paper,the research progress of domestic and foreign scholars in the field of ETEC vaccine were summarized,and the advantages and disadvantages,experimental and applied studies of various swine ETEC vaccines were summarized to provide references for future studies on ETEC vaccine.

Key words: enterotoxigenic Escherichia coli (ETEC); piglet diarrhea; immunity; vaccine

CLC Number:

S858.28

YANG Dehong, MAI Kaijie, ZHU Yuanjun, LIU Yangyang, LUO Cuifen, ZHOU Qingfeng, LIU Junfa. Research Progress on New Vaccines Against Swine ETEC in Both Domestic and Overseas[J]. , 2019, 46(7): 2119-2126.

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Research Progress on New Vaccines Against Swine ETEC in Both Domestic and Overseas

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