芩黄清肺散的急性毒性和长期毒性研究

doi:10.16431/j.cnki.1671-7236.2018.01.029

Abstract

Abstract:

The acute toxicity and long-term toxicity tests were carried out in order to explore the safety of Qinhuang qingfei powder (QQP).In the acute toxicity test, mice were given QQP decoction (6.00 mg/(g·BW))for one week, and the LD₅₀ was measured. In long-term toxicity test, 96 SD rats were randomly divided into high, middle and low dose groups (giving QQP decoction 32.00, 16.00 and 8.00 mg/(g·BW), respectively, which was equivalent to 96, 48 and 24 times clinical dose) and control group, each group of 24, half male and half female. QQP was processed and added to rats' feed for 30 d. The rats were weighed every week and the rats' water intake, feed intake, body weight and mental activity were recorded. On the 30th day and the 45th day of feeding, blood samples were taken for measuring the indexes of hematology, blood biochemistry and pathology. The results showed that LD₅₀ of mice was more than 6.00 mg/(g·BW) in acute toxicity test. It was non-toxic actually. In the long-term toxicity test, the differences were not significant in body weight, water intake, feed intake, hematological index or blood biochemical index between dose groups and control group (P>0.05). Most of the major organs of rats were dissected without any lesions and no lesion was observed within histopathological samples (including heart, liver, spleen, lung, kidney and testis/ovary). The test showed that QQP was a safe drug in clinical practice.

Key words: Qinhuang qingfei powder; acute toxicity test; long-term toxicity test

CLC Number:

R285.1

LIU Jundan, CHEN Caiping, QIU Wencai, LI Ziyuan, LIANG Weishen, TANG Luping, HE Yongming. Study on Acute Toxicity and Long-term Toxicity of Qinhuang Qingfei Powder[J]. , 2018, 45(1): 225-233.

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Study on Acute Toxicity and Long-term Toxicity of Qinhuang Qingfei Powder

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