黄酮类化合物抗菌作用及机制的研究进展

Abstract

Abstract: Along with the extensive use of antibiotics in clinical prevention and treatment, the problem of bacterial drug resistance is on the rise, especially the numbers of pan-drug resistance strains and multi-drug resistance strains increase obviously. It is hard for drug resistance to be generated by Chinese herbs with special antimicrobial mechanism. Therefore, the research and development of antagonizing drug-resistance Chinese herbs and the study of their antimicrobial mechanism draw more and more attention. Natural flavonoids possess certain antimicrobial activity and most species of them have strong inhibiting effect but little untoward effect on gram-positive bacterium such as S.aureus, Streptococcus and Bacillus subtilis.What's more, it is difficult for them to develop drug resistance. The antimicrobial action and antimicrobial mechanism of flavonoids were summarized in order to provide theoretical basis for further study of flavonoids antagonizing drug-resistance bacteria agents in this review.

Key words: flavonoids; antibacterial action; mechanism; bacterium

CLC Number:

S859

YANG Cai-xia, TIAN Chun-lian, GENG Jian, HAN Xue, HAN Li-mei, LIU Ming-chun. Research Progress on Antibacterial Action and Mechanism of Flavonoids[J]. , 2014, 41(9): 158-162.

References

1 王亚男,柳秉润,邓旭明,等. 芦丁对金黄色葡萄球菌Sortase A的抑制作用[J]. 吉林农业大学学报,2013,35(3):303～307.

2 王林青,崔保安,张红英. 金银花药理作用研究进展[J]. 中国畜牧兽医,2007,34(11):91～95.

3 王茹,谢印乾,沈志强,等. 蜂胶的免疫增强作用及其在疫苗中的应用[J]. 中国畜牧兽医,2007,34(2):93～95.

4 王海涛. 大豆异黄酮对金黄色葡萄球菌的抑菌机制研究[J]. 中国农业科学,2009a,42(7):2586～2591.

5 王海涛. 大豆异黄酮的抑菌活性及其机制的研究[D]. 大连:辽宁师范大学,2009b.

6 王棋文,宋德荣,李剑勇,等. 抗炎药物及作用机理最新研究进展[J]. 中国畜牧兽医,2010,37(3):211～213.

7 车清明,刘根新. 中草药抑菌作用的研究进展[J]. 中兽医学杂志,2013(4):58～59.

8 冯小强,李小芳,杨声,等. 壳聚糖对细菌细胞膜及膜蛋白的作用[J]. 食品科学,2009,30(13):84.

9 卢佳琨. 败酱草中黄酮类化合物的提取及其抗氧化活性、抑制生物被膜作用的研究[D]. 锦州:渤海大学,2013.

10 玄红专,胡福良. 黄酮类化合物抑制微生物活性及其作用机制[J]. 天然产物研究与开发,2010,22:171～175.

11 石治强,吴雨珊,杨文钰,等. 大豆异黄酮抑菌的研究进展[J]. 大豆科学,2011,30(6):1047～1049.

12 吴小琴. 黄酮-8-羧酸类化合物的合成及抑菌活性的研究[D].南昌:南昌大学,2011.

13 张金杰,吕文文,翁远超. 野菊花中黄酮类成分的抗菌活性及指纹图谱[J]. 国际药学研究杂志,2013,40(6):807～812.

14 李叶,唐国涛,刘建学. 黄酮类化合物抑菌作用的研究进展[J]. 农产品加工(学刊),2008(12):53～56.

15 苏锐,崔丽霞.黄酮类化合物抑菌抗病毒活性的研究[J]. 农业技术与装备,2011,208:30～33.

16 杭永付,薛晓燕,方芸,等. 中药抗菌和逆转耐药作用机制研究进展[J]. 中国药房,2011,22(47):4504～4507.

17 赵清风,陈介南,张林,等. AgNO₃对大肠杆菌和金黄色葡萄球菌的抗菌作用及机制[J]. 生物加工过程,2011,9(3):52.

18 黄国霞,李军生,阎柳娟. 几种中药提取物的抑菌作用及机理研究[J]. 时珍国医国药,2011,22(2):425～426.

19 曾春晖,杨柯,徐明光,等. 广西藤茶总黄酮对金黄色葡萄球菌抗菌机制研究[J]. 中国实验方剂学志,2013,19(10):249～252.

20 游庭活,刘凡,温露. 黄酮类化合物抑菌作用研究进展[J]. 中国中医杂志,2013,38(21):3645～3650.

21 Aremu A O, Fawole O A, Chukwujekwu J C, et al. In vitro antimicrobial, anthelmintic and cyclooxygenase-inhibitory activities and phytochemical analysis of Leucosidea sericea[J]. J Ethnopharmacol, 2010, 131(1): 22～27.

22 Cushnie T P, Lamb A J. Recent advances in understanding the antibacterial properties of flavonoids[J]. Int J Antimicrob Agents, 2011, 38: 99～107.

23 Dorothy A O, Hafizah Y C, Neil A K, et al. Antibacterial and antioxidant activities of flavonoids from Lannea alata (Engl.)Engl.(Anacardiaceae)[J]. Phytochemistry Letters, 2013, 6(3): 476～481.

24 Dzoyem J P, Hamamoto H, Ngameni B, et al. Antimicrobial action mechanism of flavonoids from Dorstenia species[J]. Drug Discoveries & Therapeutics, 2013, 7(2): 66～72.

25 Fabri R L, Nogueira M S, Braga F G, et al. Mitracarpus frigidus aerial parts exhibited potent antimicrobial, antileishmanial, and antioxidant effects[J]. Bioresour Technol, 2009, 100: 428～433.

26 Haraguchi H, Tanimoto K, Tamura Y, et al. Mode of antibacterial action of retrochalcones from Glycyrrhiza inflata[J]. Phytochemistry, 1998, 48: 125～129.

27 Hendrich A B. Flavonoid-membrane interations: Possible conesquences for biological effects of some polyphenolic compounds[J]. Acta Pharmacol Sin, 2006, 27: 27～40.

28 Kang S S, Kim J G, Lee T H, et al. Flavonols inhibit sortases and sortase-mediated Staphylococcus aureus clumping to fibrinogen[J]. Biol Pharm Bull, 2006, 29(8): 1751.

29 Kerubo L O, Midiwo J O, Derese S, et al. Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus[J]. Nat Prod Commun, 2013, 8: 175～176.

30 Koru O, Toksoy F, Acikel C H, et al. In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens[J]. Anaerobe, 2007, 13: 140～145.

31 Leonidah K O, Beatrice A, Beth Ndund, et al. Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia[J]. South African Journal of Botany, 2014, 91:58～62.

32 Ma D, Zhang Y, Yang T, et al. Isoflavone intake inhibits the development of 7, 12-dimethylbenz(a) anthracene(DMBA)-induced mammary tumors in normal and ovariectomized rats[J]. J Clin Biochem Nutr, 2014, 54(1): 31～38.

33 Mukne A P, Viswanathan V, Phadatare A G. Structure pre-requisites for isoflavones as effective antibacterial agents [J]. Pharmacogn Rev, 2011, 5(9): 13～18.

34 Rasul A, Millimouno F M, Eltayb W A, et al. Pinocembrin: A novel natural compound with versatile pharmacological and biological activities[J]. Bio Med Research International, 2013(2013): 1～9.

35 Sivasothy Y, Sulaiman S F, Ooi K L, et al. Antioxidant and antibacterial activities of flavonoids and curcuminoids from Zingiber spectabile Griff[J]. Food Control, 2013, 30(2): 714～720.

36 Süzge-Seluk S, Birteksz A S. Flavonoids of Helichrysum chasmolycicum and its antioxidant and antimicrobial activities[J]. South African Journal of Botany, 2011, 77(1): 170～174.

37 Ulanowska K, Tkaczyk A, Konopa G, et al. Differential antibacterial activity of genistein arising from global inhibition of DNA, RNA and protein synthesis in some bacterial strains[J]. Archives of Microbiology, 2006, 184 (5): 271～278.

38 Uzel A, Sorkun K, Ona O, et al. Chemical compositions and antimicrobial activities of four different Anatolian propolis samples[J]. Microbiol Res, 2005, 160: 189～195.

39 Wang L J, Yang X S, Qin P Y, et al. Flavonoid composition, antibacterial and antioxidant properties of tartary buckwheat bran extract[J]. Industrial Crops and Products, 2013, 49: 312～317.

40 Wu D, Kong Y, Han C, et al. D-alanine: D-alanine ligase as a new target for the flavonoids quercetin and apigenin[J]. Int J Antimicrob Agents, 2008, 32: 421～426.

41 Wu T, He M Y, Zang X X, et al. A structure-activity relationship study of flavonoids as inhibitors of E.coli by membrane interaction effect[J]. Biochimica et Biophysica Acta, 2013, 1828(11): 2751～2756.

42 Zhang F, Luo S Y, Ye Y B, et al. The antibacterial efficacy of an aceraceous plant [Shantung maple (Acer truncatum Bunge)] may be related to inhibition of bacterial β-oxoacyl-acyl carrier protein reductase(FabG)[J]. Biotechnol Appl Biochem, 2008a, 51:73～78.

43 Zhang L, Kong Y H, Wu D L, et al. Three flavonoids targeting the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori:Crystal structure characterization with enzymatic inhibition assay[J]. Protein Sci, 2008b, 17: 1971～1978.

44 Zhang X J, Li L Y, Kelsang N, et al. Flavonoids from Tibetan medicine Oxytropis falcate Bunge[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(2): 99～105.

45 Zhang Y M, Rock C O. Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type Ⅱ fatty-acid synthase[J]. J Biol Chem, 2004, 279: 30994～31001.

[1]	SONG Yue, SU Shengjie, ZHANG Fan, BAI Fan, DAI Lingli, WANG Na, WANG Dawei, YANG Qianwen, ZHAO Shihua, ZHANG Yuemei. Prokaryotic Expression and Polyclonal Antibody Preparation of Mannheimia haemolytica Truncated Leukotoxin [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2479-2486.
[2]	ZHAO Qianhui, LIU Ying, JIAO Yulan, SHI Wanyu, CHEN Fuxing. Exploring of the Mechanism of Cuscuta chinensis Flavonoids in Alleviating Reproductive Damage in Offspring Rats Exposed to Bisphenol A During Pregnancy Based on Network Pharmacology [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2550-2561.
[3]	LU Yukui, LIU Jiaqi, ZHONG Jiacheng, CHEN Jidang, ZHU Wanjun, ZHANG Yishan, ZHANG Jipei. Isolation,Identification and Pathogenicity Analysis of Avibacterium paragallinarum from Geese [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2562-2572.
[4]	ZHANG Jingyi, CHEN Li, HUANG Siyang, CHEN Xiang, LIU Zongping, TONG Xishuai. Research Progress on Pathogenic Characteristics and Pathogenicity of Ehrlichia canis [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2023-2031.
[5]	XU Chenghui, ZHANG Xumei, YANG Tong, LI Jiahui, SUN Yawei, SHI Huijun, FU Qiang, YANG Li. Molecular Mechanism of Leonurine in the Treatment of Intestinal Inflammation Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2103-2113.
[6]	CHEN Tianbao, WANG Yani, LIU Baoling, WANG Gang, WANG Xiaohu, LIU Xuhui, CAI Rujian, HE Dongsheng. Research Progress on the Anti-Porcine Reproductive and Respiratory Syndrome Virus Effect and Mechanism of Traditional Chinese Medicine [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2114-2129.
[7]	GUO Bingyu, LI Li, LI Chen, KONG Xianghui. Role and Molecular Mechanism of Mpeg1 in Pathogen Clearance [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1584-1592.
[8]	DOU Jiahong, WANG Ziying, YANG Juan, ZHOU Weiwei, ZHANG Tongcun, HE Hongpeng, DAI Xiaofeng, LI Xiumei. Analysis of the Active Ingredients and Mechanism of Radix Paeoniae Rubra Antioxidative Stress Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1229-1240.
[9]	QIN Zhiyun, JIANG Huaizhi. An Overview of Research on Skin Hair Follicle Development and Regulatory Mechanism in Sheep During the Fetal Period [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 638-646.
[10]	HAN Guorui, XIAO Xiaoyue, ZHANG Yang, LI Yanhua, CHEN Xueying, WANG Xiumin, QIN Junjie, LIU Yanyan. Mechanism of Gui Qi Yimu Oral Liquid in the Treatment of Sus scrofa Qi and Blood Two Deficiency Syndrome Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 722-733.
[11]	MENG Yingwen, LI Yuehua, SHA Zhou, LI Chenyu, GONG Youquan, DONG Yaqin, WEI Rong, ZOU Fengcai, NI Bo. Screening of the Natural Products Against Senecavirus A and Study on Its Mechanism of Antagonism [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 734-744.
[12]	WANG Wei, LI Chunzhu, WANG Shasha, SANG Rui, GE Bingjie, LI Chunting, ZHAO Xin, LIU Xinman, YU Minghong, ZHANG Xuemei. Study on the Protective Mechanism of Traditional Chinese Medicine Combined with Probiotics on Diarrhea Caused by E.coli in Mice [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 779-788.
[13]	LIU Lin, WU Baoqing, GUO Xiaoyin, YU Wenhui, TIAN Lang. Study on Bacteriostatic Action of Aqueous Extract of Granati pericarpium Against Multi-drug Resistant Escherichia coli of Swine [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 328-340.
[14]	MIAO Weiyuan, ZHANG Siqi, HUANG Changqiao, ZHAO Yi, CHEN Qi, XIE Xiaodong, WEI Yingyi, YU Meiling, HU Tingjun. Effect of N-butanol Fraction of Polygonum hydropiper Flavonoids on Levels Oxidative Stress-related Factors in 3D4/2 Cells Infected with PRV [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 349-358.
[15]	LIU Hongying, WANG Jingyu, CUI Zhenzhen, MA Qingxia, WANG Tingting, LI Jianming, SHI Kun, GONG Qinglong, DU Rui, LENG Xue. Research Progress on Immune Adjuvant Effect and Related Mechanism of Active Ingredients of Traditional Chinese Medicine on Animal Vaccines [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 390-397.

Research Progress on Antibacterial Action and Mechanism of Flavonoids

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments