微量元素硒的类胰岛素作用研究进展

Abstract

Abstract: During recent years，it has been found that selenium （Se） has insulin-mimetic effects on the promotion of glucose uptake into cells，glucose metabolism and signal transduction based on the relationship of Se and diabetes, but the effect dose of Se can only be obtained with nearly toxic doses and are not suitable for humans.This paper gives a brief review of research progress on insulin-mimetic effects of Se，in favor of an extensive study on the regulation mechanism of Se in glucose metabolism，so as to provide a reference for applying Se for regulation of disorders of glucose metabolism in stressed animals.

Key words: selenium; insulin; glucose metabolism

JI Feng，HUANG Jian-guo，WANG Ya-lei，MA Chun-jian，SU Qi. Research Progress on Insulin-mimetic Effects of Selenium[J]. .

References

1 亢守亭.微量元素硒的营养研究进展［J］.中国畜牧兽医，2009，36（1）：34～37.
2 田维，王威.几种微量元素对糖代谢的影响［J］.微量元素与健康研究，2010，27（5）：52～55.
3 张利娜，徐世文.缺硒致胰腺损伤的研究进展［J］.中国饲料，2008，21：7～10.
4 张桂珍，郑德明，高申，等.硒和维生素E对胰岛细胞保护作用的研究［J］.营养学报，2000，22（1）：5～8.
5 周军，白兆帅，徐辉碧，等.硒蛋白与糖尿病——硒的两面性［J］.化学进展，2013，25（4）：488～494.
6 林德馨译.图解生物化学［M］.第5版.北京：科学出版社，2011.
7 赵景鹏.应激影响肉鸡骨骼肌葡萄糖代谢的机制研究［D］.泰安：山东农业大学，2007.
8 盛希群.硒与糖尿病关系的研究［D］.武汉：华中科技大学，2004.
9 廖明.硒对于氧化损伤大鼠肝细胞糖代谢关键酶的影响及其机制的研究［D］.天津：天津医科大学，2009.
10 Harvey R A，Ferrier D R.林德馨译.图解生物化学［M］.第5版.北京：科学出版社，2011.
11 Becker D J，Reul B，Ozcelikay A T，et al.Oral selenate improves glucose homeostasis and partly reverses abnormal expression of liver glycolytic and gluconeogenic enzymes in diabetic rats［J］.Diabetologia，1996，39（1）：3～11.
12 Berg E A，Wu J Y，Campbell L，et al.Insulin-like effects of vanadate and selenate on the expression of glucose-6-phosphate dehydrogenase and fatty acid synthase in diabetic rats［J］.Biochimie，1995，77（12）：919～924.
13 Bleys J，Navas-Acien A，Guallar E.Serum selenium and diabetes in US adults［J］.Diabetes Care，2007，30（4）：829～834.
14 Cheatham B，Vlahos C J，Cheatham L，et al.Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase，DNA synthesis，and glucose transporter translocation［J］.Molecular and Cellular Biology，1994，14（7）：4902～4911.
15 Ciulan V，Mot T，Morar D，et al.Researches regarding the influence of differential intake of vitamin E and selenium on enzyme profiles at broiler［J］.Current Opinion in Biotechnology，2013，24：S108.
16 Cross D A，Alessi D R，Vandenheede J R，et al.The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin，but not by rapamycin：Evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf［J］.Biochemical Journal，1994，303：21～26.
17 Ezaki O.The insulin-like effects of selenate in rat adipocytes［J］.Journal of Biological Chemistry，1990，265（2）：1124～1128.
18 Fürnsinn C，Englisch R，Ebner K，et al.Insulin-like vs. non-insulin-like stimulation of glucose metabolism by vanadium，tungsten，and selenium compounds in rat muscle［J］.Life Sciences，1996，59（23）：1989～2000.
19 Gabbay R A，Sutherland C，Gnudi L，et al.Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway［J］.Journal of Biological Chemistry，1996，271（4）：1890～1897.
20 Ghosh R，Mukherjee B，Chatterjee M.A novel effect of selenium on streptozotocin-induced diabetic mice［J］.Diabetes Research，1994，25（4）：165～171.
21 Heart E，Sung C K.Insulin-like and non-insulin-like selenium actions in 3T3-L1 adipocytes［J］.Journal of Cellular Biochemistry，2003，88：719～731.
22 Kahn C R，White M F，Shoelson S E，et al.The insulin receptor and its substrate：Molecular determinants of early events in insulin action［J］.Recent Progress in Hormone Research，1993，48：291～339.
23 McNeill J H，Delgatty H L M，Battell M L.Insulin-like effects of sodium selenate in streptozotocin-induced diabetic rats［J］.Diabetes，1991，40：1675～1679.
24 Mueller A S，Pallauf J，Rafael J.The chemical form of selenium affects insulinomimetic properties of the trace element：Investigations in type Ⅱ diabetic db/db mice［J］.The Journal of Nutritional Biochemistry，2003，14（11）：637～647.
25 Mueller A S，Pallauf J.Compendium of the antidiabetic effects of supranutritional selenate doses.In vivo and in vitro investigations with type Ⅱ diabetic db/db mice［J］.The Journal of Nutritional Biochemistry，2006，17（8）：548～560.
26 Mueller A S，Mueller K，Wolf N M，et al.Selenium and diabetes：An enigma［J］.Free Radic Res，2009，43：1029～1059.
27 Pillay T S，Makgoba M W.Enhancement of EGF and insulin-stimulated tyrosine phosphorylation of endogenous substrates by sodium selenite［J］.FEBS Lett，1992，308：38～42.
28 Pinto A，Speckmann B，Heisler M，et al.Delaying of insulin signal transduction in skeletal muscle cells by selenium compounds［J］.Journal of Inorganic Biochemistry，2011，105：812～820.
29 Pinto A，Juniper D T，Sanil M，et al.Supranutritional selenium induces alterations in molecular targets related to energy metabolism in skeletal muscle and visceral adipose tissue of pigs［J］.Journal of Inorganic Biochemistry，2012，114：47～54.
30 Plano D，Ibanez E，Calvo A，et al.Novel library of selenocompounds as kinase modulators［J］.Molecules，2011，16（8）：6349～6364.
31 Rayman M P.The importance of selenium to human health［J］.Lancet，2000，356（9225）：233～241.
32 Rayman M P，Blundell-Pound G，Pastor-Barriuso R，et al.A randomized trial of selenium supplementation and risk of type-2 diabetes，as assessed by plasma adiponectin［J］.PLoS One，2012，7（9）：e45269.
33 Seger R，Krebs E G.The MAPK signaling cascade［J］. FASEB Journal，1995，9（9）：726～735.
34 Shepherd P R，Nave B T，Siddle K.Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes：Evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase［J］.Biochemical Journal，1995，305：25～28.
35 Stapleton S R，Garlock G L，Foellmi-Adams L，et al.Selenium：Potent stimulator of tyrosyl phosphorylation and activator of MAP kinase［J］.Biochimica et Biophysica Acta (BBA)-Molecular Cell Research，1997，1355（3）：259～269.
36 Stapleton S R，Jivraj S，Wagle A.Insulin and the insulin-mimetic selenium mediate the regulation of glucose-6-phosphate dehydrogenase gene expression via different signal proteins［J］.FASEB Journal，1998，12：1404.
37 Steinbrenner H，Speckmann B，Pinto A，et al.High selenium intake and increased diabetes risk：Experimental evidence for interplay between selenium and carbohydrate metabolism［J］.J Clin Biochem Nutr，2011，48（1）：40～45.
38 Stranges S，Marshall J R，Natarajan R，et al.Effects of long-term selenium supplementation on the incidence of type 2 diabetes［J］.Ann Intern Med，2007，147：217～223.
39 Van Horn D J，Myers M G，Jr Backer J M.Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor［J］.Journal of Biological Chemistry，1994，269：29～32.
40 Wagle A，Jivraj S，Garlock G L，et al.Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin sensitive and requires phosphatidylinositol 3-kinase［J］.J Biol Chem，1998，273：14968～14974.
41 Xu T，Liu Y，Yuan B.Effect of insulin in combination with selenium on IRS/PI3K-mediated GLUT4 expression in cardiac muscle of diabetic rats［J］.European Review for Medical and Pharmacological Sciences，2011，15（12）：1452～1460.

[1]	GUO Yaru, LI Kexin, WANG Li, LIU Jinyu, SHI Lei, REN Youshe. Effects of Selenium on Lead-Induced Apoptosis of Mouse Leydig Cells in vitro [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1404-1411.
[2]	CUI Shuang, Wurlig, Alder, XIAO Min, WANG Jianqiu, GONG Jian. Effects of Yeast Selenium Supplementation on Gastrointestinal Microflora in Sheep Under Grazing Conditions [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 952-965.
[3]	GU Dongdi, DENG Zaishuang, REN Man, SUN Yuhao, GU Youfang, JIN Guangming, JIN Erhui. Effects of Cordyceps Powder Combined with Yeast Selenium on Laying Performance,Egg Quality,Antioxidant and Immune Function in Middle Egg-laying Peak of Laying Hen [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(7): 2404-2414.
[4]	ZHU Xingyi, LIN Fanghui, XU Jingnan, LIN Liming, YANG Zhengtao, CAO Changyu, WANG Kai. Antagonistic Effect of Selenium on Aluminum-induced Oxidative Stress and Inflammation in the Spleen of Mice [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(5): 1868-1875.
[5]	LI Yuanhui, FU Chunni, LI Pengcheng, PENG Yukai, LI Liuan, ZHANG Jianbin, QIN Shunyi. Effect of Selenium-Enriched Lactic Acid Bacteria on Apoptosis of Chicken Small Intestinal Epithelial Cells Induced by Aflatoxin B₁ [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(12): 4702-4709.
[6]	FU Chunni, LI Yuanhui, LI Pengcheng, LI Liuan, QIN Shunyi. Effects of Selenium-oligochitosan Against Zearalenone on the Expression of Tight Junction Protein in IPEC-J2 Cells [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(11): 4311-4318.
[7]	WANG Lisai, LIAO Xiudong, FENG Yanzhong, ZHANG Liyang, LYU Lin, LI Sufen, LUO Xugang. Effect of Dietary Selenium Level on Growth Performance and Meat Quality of Broilers from 22 to 42 Days of Age [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(7): 2063-2070.
[8]	GAO Kai, JIAN Xinrui, GENG Chunyin, ZHANG Min. Effect of Monascus Synbiotic,Yeast-Selenium-Germanium Culture and Their Compound Preparation on Growth Performance,Apparent Digestibility and Serum Biochemistry of Weaned Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2019, 46(9): 2583-2591.
[9]	GAO Kai, JIAN Xinrui, GENG Chunyin, ZHANG Min. Effect of Monascus Synbiotic,Yeast-Selenium-Germanium Culture and Their Compound Preparation on Gut Structure and Rectal Flora of Weaned Piglets [J]. , 2019, 46(8): 2330-2337.
[10]	HUO Bin, WU Ting, SONG Chunjie, SHEN Xiaoyun. Effects of Selenium Deficiency in Alpine Meadow on Blood Biochemical Indexes and Antioxidant Systems of Yaks [J]. , 2019, 46(4): 1053-1062.
[11]	GAO Ai-qin, ZHU Yu-xia, LEI Zhen-hua, ZHANG Qiu-xu, WANG Nai-feng, CAO Ping. Effect of Organic Selenium and Vitamin E on Meat Quality Trait,Blood Biochemical Indexes and Antioxidant Indexes of Broiler [J]. , 2017, 44(6): 1694-1700.
[12]	CHEN Xi-ping, WANG Ye, JING Dong-lin, LI Hao-jie, YANG Wen-hao. Effects of Selenium Yeast on Growth Performance and Some Blood Biochemical Indexes in Laying Ducks of Rearing Period in Cages under High Ambient Temperature [J]. , 2017, 44(11): 3208-3213.
[13]	SHI Li-guang, ZHOU Xiong, XUN Wen-juan, HOU Guan-yu, ZHOU Han-lin, HUANG Xian-zhou. Effect of Se and VE Supplement on Semen Quality, Antioxidant Enzyme Activities and Heat Shock Protein Expression of Goat in High Temperature Season [J]. , 2016, 43(1): 101-107.
[14]	LIU Li-na, XU Fa-ting, ZHAO Fang-hong, QIN Shun-yi, YAO Wan, LIU Jia, LI Yu-zhu. Detection of Selenium Content in Beef by Hydride Atomic Fluorescence Spectrometry [J]. , 2015, 42(9): 2399-2404.
[15]	WANG Qian-guang，LIU Qiu，ZHANG Bao-ping，TONG Xue-qin，DONG Li-jun，GAO Hui-lin，REN Guo-ji. Effects of Different Sources and Levels of Selenium on Growth Performance and Tissue Selenium Content of 10～11 months Porcupine [J]. , 2014, 41(7): 118-121.

Research Progress on Insulin-mimetic Effects of Selenium

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments