Abstract: This experiment was aimed to study the effects of Monascus synbiotic,yeast-selenium-germanium culture and their compound preparation instead of antibiotics on growth performance of weaned piglets.Eighty healthy piglets (7.57 kg±0.49 kg) with (28±1) d were randomly divided into 4 groups with 5 replicates per group and 4 piglets per replicate.The pigs in control group were fed basal diet with 25 mg/kg colistin sulfate and 45 mg/kg chlortetracycline.The diets of groups 1,2 and 3 were added with 0.5% Monascus synbiotics,0.25% Monascus synbiotics+0.25% yeast-selenium-germanium culture and 0.5% yeast-selenium-germanium culture.The test period was 42 d,which was divided into 3 stages,14 days per stage (1-14,15-28,29-42 d).The results showed that:①Compared with the control group,in all stages of the experiment,the ADG of the groups 1 and 2 were significant or extremely significant increased (P<0.05;P<0.01).At 29-42 d,the F/G of all the experimental groups were significantly decreased (P<0.05).Compared with the control group,the final weight of piglets in the experimental groups had extremely significant or significant increased (P<0.01;P<0.05).②Compared with the control group,the diarrhea rate (DR) and diarrhea index (DI) of the group 1 were significantly decreased (P<0.05) on the 1-7 d of the experiment.In the whole trial period,compared with the control group,the DR and DI of the group 1 and the DR of the group 2 were significantly lower (P<0.05).Compared with the group 3,the DI of the group 1 and 2 showed an extremely significant or significant decrease (P<0.01;P<0.05).③Compared with the control group,the apparent digestibility of CP and EE of the groups 1 and 2 were significantly or extremely significantly increased (P<0.05;P<0.01) at the 1-28 d of the experiment.Compared with the control group,the apparent digestibility of DM,CP and EE of all the experimental groups were significantly or extremely significantly increased (P<0.05;P<0.01),and the apparent digestibility of P of the groups 1 and 2 were significantly increased (P<0.05) on the 29-42 d of the experiment.④Compared with the control group,the serum GH and IGF-1 levels of all the experimental groups were significantly or extremely significantly increased (P<0.05;P<0.01),and the serum GHRIH of all the experimental groups was significantly or extremely significantly decreased (P<0.05;P<0.01).Among them,the serum IGF-1 level of the group 2 was significantly higher than that in the groups 1 and 3 (P<0.05).Compared with the control group,the serum COR levels of the groups 1 and 2 were significantly increased (P<0.05).In summary,compared with antibiotics,0.5% compound preparation of Monascus synbiotic and yeast-selenium-germanium culture could effectively prevent diarrhea in weaned piglets and improve the growth of weaned piglets.The 0.5% Compound Preparation of Monascus synbiotic and yeast-selenium-germanium culture could replace 25 mg/kg colistin sulfate and 45 mg/kg aureomycin in diet under this experiment.

Key words: Monascus ynbiotics; antibiotics; yeast-selenium-germanium culture; weaned piglets; growth performance