适度运动减轻流感小鼠肺脏炎性损伤的研究

Abstract

Abstract: The purpose of this study was to explore whether moderate exercise could reduce inflammatory injury in lungs and prolong the survival of mice with influenza. The mice were divided into two groups (control and moderate exercise groups), control group’s mice were fed in the same condition as moderate exercise group, without treadmill exercise, the mice in moderate exercise group performed treadmill exercise (8 to 9 m/min, 30 min/d, 5 times/week for 2 weeks), all mice were nasally infected with FM1 influenza virus on day 14. On day 3 after being infected with the virus, five mice in exercise and control groups were killed for the lungs, two of which were for pathological analysis and three of which were for detection of IL-6, TNF-α, MCP-1 and virus titer. On day 3 after infected with the virus, there were lower inflammatory cells, virus titers and IL-6, TNF-α, MCP-1 （P＜0.05） in the lungs of mice in exercise group than that in control group, furthermore the survivals of mice in exercise group were also apparently longer than that in control group. Moderate exercise could significantly reduce the inflammatory injury in lungs of the mice with influenza and apparently prolong the survival of the mice.

Key words: moderate exercise; lung injury; inflammatory; influenza

HU Guang-xia, GU Ke-peng. Study on Moderate Exercise to Reduce Influenza Animal Lung Inflammatory Injury in Mice Model[J]. .

References

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Study on Moderate Exercise to Reduce Influenza Animal Lung Inflammatory Injury in Mice Model

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