异荭草素的生物学功能研究进展

doi:10.16431/j.cnki.1671-7236.2025.04.012

Abstract

Abstract: Isoorientin is a natural flavonoid plant compound with a wide range of biological activities and pharmacological effects.In nature,isoorientin mainly exists in many plants,such as Fagopyrum esculentum Moench,Gentiana straminea Maxim,Kummerowia striata (Thunb.) Schindl, Lythrum salicaria L and Polygonum orientale L.Previous studies have shown that isoorientin has multiple effects such as improving osteoporosis,treatment of diabetes,antidepressant,anti-tumor,and reducing organ damage.Its mechanism of action is mainly achieved through the biological activities of antioxidant stress,anti-inflammatory,and regulation of cell apoptosis.The key proteins involved in this process include nuclear factor E2-related factor 2 (Nrf2),nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB),mitogen-activated protein kinase (MAPK),tumor necrosis factor-α (TNF-α),interleukin-1β (IL-1β),phosphatidylinositide 3-kinases (PI3K),protein kinase B (Akt),heme oxygenase-1 (HO-1),etc.In addition,current research on isoorientin mainly focuses on acute and subacute toxicity tests on rats,mice and related cell lines,lacking basic experiments on other animals or cells such as livestock and poultry,which to some extent affects the product development and clinical application of isoorientin.This article reviewed the functional activity of isoorientin,and proposes prospects for its clinical application,in order to provide new ideas and theoretical support for further research on the biological activity of isoorientin and expand its clinical application.

Key words: isoorientin; antioxidant; anti-inflammatory; regulating cell apoptosis

CLC Number:

S816.7

LUO Tongwang, JIN Yan, SHENG Yifan, WANG Shujie, SONG Houhui, SHAO Chunyan. Research Progress on the Biological Functions of Isoorientin[J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(4): 1579-1589.

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Research Progress on the Biological Functions of Isoorientin

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