α-倒捻子素对肉鸡生长性能、免疫功能、抗氧化能力和解毒功能的影响

doi:10.16431/j.cnki.1671-7236.2025.03.014

Abstract

Abstract: 【Obiective】 The experiment was conducted to investigate the effects of different levels of α-mangostin in basic diet on growth performance,immune function,antioxidant capacity and detoxification function of Yellow-feathered broilers,and to provide evidence for its application in broilers.【Method】 A total of 900 1-day-old Ephedra broiers (female) were divided into 6 treatment groups with 6 replicates per group and 25 broilers per replicate.The diets in 6 treatment groups were supplemented with 0,15,30,60,120,and 240 mg/kg α-mangostin in the basal diet, respectively.The experiment lasted for 54 d.One broiler weighted close to the average body weight was selected from each replicate for blood collection and slaughter on the end of experiment,plasma was separated to determine cytokine content and antioxidant index,liver was collected to determine antioxidant and detoxification function related index.【Result】 ①The body weight and average daily gain of broilers increased linearly and quadratically with the increase of α-mangostin supplemental level (P＜0.05).There were no significant differences in average daily feed intake,feed to gain ratio and mortality rate of broilers among different treatment groups (P＞0.05).②The contents of interleukin-1β (IL-1β),IL-6,IL-10 and malondialdehyde (MDA) in plasma of broilers were significantly affected by different α-mangostin supplemental levels (P＜0.05),and the contents of IL-1β,IL-6 and MDA were linearly and quadratically decreased with the increase of α-mangostin supplemental levels (P＜0.05),IL-10 content increased linearly and quadratically (P＜0.05).③Dietary supplemental different levels of α-mangostin significantly affected the liver malondialdehyde (MDA) content,total superoxide dismutase (T-SOD) and glutathione S transferase (GSH-ST) activities of broilers (P＜0.05),and with the increase of α-mangostin supplemental levels,the MDA content was linearly and quadratically decreased (P＜0.05),T-SOD activity increased linearly and quadratically (P＜0.05),GSH-ST activity increased linearly (P＜0.05).【Conclusion】 Dietary α-mangostin could improve growth performance,immune function,antioxidant capacity and detoxification function of Yellow-feathered broilers aged 1 to 54 days.Using the body weight and average daily gain as main evaluation indexes,according to the quadratic curve model,the optimal supplemental levels of α-mangostin in diet were 188 and 156 mg/kg, respectively.

Key words: α-mangostin; Yellow-feathered broilers; growth performance; immune function; antioxidant capacity; detoxification function

CLC Number:

S816.7

FAN Qiuli, TAO Zhengguo, LI Hui, GOU Zhongyong, WANG Yibing, LIN Xiajing, YE Jinling, JIANG Shouqun. Effects of α-mangostin on Growth Performance,Immune Function, Antioxidant Capacity and Detoxification Function of Broilers[J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(3): 1123-1130.

References

[1] AISHA F A,ABU-SALAH K M,SIDDIQUI M J.Quantification of α-,β- and γ-mangostin in garcinia mangostana fruit rind extracts by a reverse phase high performance liquid chromatography[J].Academic Journals,2012,6(29):4526-4534.
[2] MEAH M S,PANICHAYUPAKARANANT P.α-mangostin-rich extract:A potential oral antibacterial agent prepared by green extraction[J].International Journal of Pharmacognosy and Phytochemical Research,2020,4(2):000201.
[3] NITIMA T A,WARANYA C,KANOKWAN J.Ethanolic garcinia mangostana extract and α-mangostin improve dextran sulfate sodium-induced ulcerative colitis via the suppression of inflammatory and oxidative responses in ICR mice[J].Journal of Ethnopharmacology,2021,265:113384.
[4] LIU D F,LONG L L,ZHENG J,et al.Inhibition of autophagy augments the anticancer activity of α-mangostin in chronic myeloid leukemia cells[J].Leukemia & Lymphoma,2014,55(3):628-638.
[5] BUELNACHONTAL M,CORREA F,HERANDEZRESENDIZ S,et al.Protective effect of alpha-mangostin on cardiac reperfusion damage by attenuation of oxidative stress[J].Journal of Medicine Food,2011,14(11):1370-1374.
[6] CHOI Y H,BAE J K,CHAE H S,et al.Alpha-mangostin regulates hepatic steatosis and obesity through SirT1-AMPK and PPAR gamma pathways in high-fat diet-induced obese mice[J].Journal of Agricultural and Food Chemistry,2015,63(38):8399-8406.
[7] SRIBOONYONG P,POOMMARIN P,SITTIYA J,et al.The utilization of mangosteen pericarp extract for anticoccidial drug replacement in broiler feed[J].International Journal of Veterinary Science and Medicine,2022,10(1):90-99.
[8] 范秋丽,陶正国,李辉,等.山竹和木豆提取物对肉鸡生长性能、血浆生化指标、肠道健康和肉品质的影响[J].动物营养学报,2024,36(3):1599-1611. FAN Q L,TAO Z G,LI H,et al.Effects of mangosteen and pigeonpea extracts on growth performance,plasma biochemical indices,intestinal health and meat quality of chickens[J]. Chinese Journal of Animal Nutrition,2024,36(3):1599-1611.(in Chinese)
[9] HAFEEZ B B,MUSTAFA A,FISCHER J W,et al.α-mangostin:A dietary antioxidant derived from the pericarp of Garcinia mangostana L.inhibits pancreatic tumor growth in xenograft mouse model[J].Antioxidants & Redox Signaling,2014,21(5):682-699.
[10] 席丽,秦新喜,杜乐响,等.地锦草总黄酮对罗斯308肉鸡生长性能、免疫功能、抗氧化能力及盲肠菌群的影响[J].中国家禽,2024,46(6):36-43. XI L,QIN X X,DU L X,et al.Effects of total flavonoids from Euphorbia humifusa on growth performance,immune function,antioxidant capacity and cecal microbiota of Ross 308 broilers[J].China Polutry,2024,46(6):36-43.(in Chinese)
[11] MA J S,CHANG W H,LIU G H,et al.Effects of flavones of sea buckthorn fruits on growth performance,carcass quality,fat deposition and lipometabolism for broilers[J].Poultry Science,2015,94(11):2641-2648.
[12] STENGER S,RLLINGHOFF M.Role of cytokines in the innate immune response to intracellular pathogens[J].Annals of the Rheumatic Diseases,2001,60(3):43-48.
[13] ZIPP F,BITTNER S,SCHAFER D P.Cytokines as emerging regulators of central nervous system synapses[J].Immunity,2023,56(5):914-925.
[14] TRIPATHY A S,VISHWAKARMA S,TRIMBAKE D,et al.Pro-inflammatory CXCL-10,TNF-α,IL-1β,and IL-6:Biomarkers of SARS-CoV-2 infection[J].Archives of Virology,2021,166(12):3301-3310.
[15] HU Y H,HAN J,WANG L,et al.α-mangostin alleviated inflammation in rats with adjuvant-induced arthritis by disrupting adipocytes-mediated metabolism-immune feedback[J].Frontiers in Pharmacology,2021,(12):69280.
[16] NUGRAHAENI D K,HADISAPUTRO S,SUWONDO A,et al.The effect of alpha-mangostin in balancing the ratio of cytokines pro-and anti-inflammation-gamma (IFN-γ/IL-10) and severity of the disease in mice infected with Mycobacterium tuberculosis multidrug-resistant[J].Asian Journal of Pharmaceutical & Clinical Research,2016,9(9):273.
[17] 陈敏,陶静,朱慧艳.α-倒捻子素通过NF-κB途径抑制LPS/ATP诱导的小胶质细胞中NLRP3炎症小体的激活[J].安徽医科大学学报,2024,59(4):575-580. CHEN M,TAO J,ZHU H Y.Alpha-mangostin inhibits LPS/ATP-induced NLRP3 inflammasome activation in microglia via the NF-κB pathway[J].Acta Universitatis Medicnalis Anhui,2024,59(4):575-580.(in Chinese)
[18] WANG F,MA H X,LIU Z G,et al.α-mangostin inhibits DMBA/TPA-induced skin cancer through inhibiting inflammation and promoting autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling pathway in mice[J]. Biomedicine & Pharmacotherapy,2017,92:672-680.
[19] JAVAN A J,SABERI M,VAYEGHAN A J,et al.The effect of dietary aloe vera gel extract supplementation on lipid peroxidation of broiler breast fillets during frozen storage[J].Journal of Veterinary Research,2013,68(3):233-240.
[20] ZHANG S,KIM I H.Effect of quercetin (flavonoid) supplementation on growth performance,meat stability,and immunological response in broiler chickens[J]. Livestock Science,2020,242:242.
[21] YAN X T,SUN Y S,REN S,et al.Dietary α-mangostin provides protective effects against acetaminophen-induced hepatotoxicity in mice via Akt/mTOR-mediated inhibition of autophagy and apoptosis[J].International Journal of Molecular Sciences,2018,19(5):1335.
[22] TIANHUA F,HAIJUN L,YAN Z,et al.Hepatoprotective effect of α-mangostin against lipopolysaccharide/D-galactosamine-induced acute liver failure in mice[J].Biomedicine & Pharmacotherapy,2018,106:896-901.
[23] 崔明宇,尹义凤,朱凤梅,等.蓬子菜总黄酮对D-半乳糖致过氧化损伤大鼠SOD、MDA和GSH-Px水平的影响[J].中医药学报,2021,49(12):47-51. CUI M Y,YIN Y F,ZHU F M,et al.Effects of FVGL on levels of SOD,MDA and GSH-Px in rats with oxidative damage induced by D-galactose[J].Acta Chinese Medicine and Pharmacology,2021,49(12):47-51.(in Chinese)
[24] 魏朝,姜茹,王平安,等.针对有机磷中毒的新型非肟类乙酰胆碱酯酶重活化剂的筛选[J].空军军医大学学报,2023,12:1155-1163. WEI C,JIANG R,WANG P A,et al.Screening of novel non-oxime acetylcholinesterase reactivators for organophosphorus poisoning[J].Joural of Air Force Medical University,2023,12:1155-1163.(in Chinese)
[25] 肖启玲,李朋辉,闫秉芳,等.猪肝羧酸酯酶1基因的克隆和在原核细胞中的功能性表达[J].畜牧兽医学报,2015,46(4):650-656. XIAO Q L,LI P H,YAN B F,et al.Cloning and functional expression of pig liver esterase 1 gene in prokaryotic cells[J]. Acta Veterinaria et Zootechnica Sinica,2015,46(4):650-656.(in Chinese)
[26] XU Z B,ZOU X P,ZHANG N,et al.Detoxification of insecticides,allechemicals and heavy metals by glutathione S-transferase SlGSTE1 in the gut of Spodoptera litura[J].Insect Science,2014,22(4):503-513.
[27] WANG Y,XIA Z,XU J R,et al.α-mangostin,a polyphenolic xanthone derivative from Mangosteen,attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation[J].Neuropharmacology,2011,62(2):871-881.

Effects of α-mangostin on Growth Performance,Immune Function, Antioxidant Capacity and Detoxification Function of Broilers

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