China Animal Husbandry and Veterinary Medicine ›› 2025, Vol. 52 ›› Issue (2): 636-644.doi: 10.16431/j.cnki.1671-7236.2025.02.014

• Nutrition and Feed • Previous Articles    

Advances in the Impact of Tryptophan and Its Bacterial Metabolites on Intestinal Barrier Function and Growth Performance in Livestock and Poultry

YANG Xinshuo1, CHANG Danyi1, XU Dandan1,2, ZHANG Haihua3, MA Qiugang1, HUANG Shimeng1   

  1. 1. National Key Laboratory of Livestock and Poultry Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China;
    2. School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China;
    3. Hebei Key Laboratory of Specialty Animal Germplasm Resources Exploration and Innovation, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China
  • Received:2024-05-15 Published:2025-01-24

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Abstract: Tryptophan (Trp) is one of the essential functional amino acid.Tryptophan and its bacterial metabolites are crucial for maintaining host intestinal homeostasis,promoting growth performance and metabolism.Tryptophan produces various beneficial bacterial metabolites through metabolic processes such as indole,kynurenine and 5-hydroxytryptamine pathways.Tryptophan and its metabolites can promote the expression of tight junction proteins in intestinal epithelial cells,increase the synthesis and secretion of mucins in the intestinal mucosal barrier.In addition,tryptophan and its metabolites promote the colonization of beneficial bacteria in the intestinal microbiota,inhibit the proliferation of pathogenic bacteria,and maintain the stability and diversity of the microbiota.The positive effects of tryptophan and its bacterial metabolites on the growth performance of livestock and poultry include increasing feed intake,daily weight gain,alleviating growth barriers,and improving the quality of livestock and poultry products.However,there is currently a lack of systematic research on the mechanism of action of tryptophan bacterial metabolites in the intestinal health,nutritional metabolism and growth performance of livestock and poultry.Future research should focus on how tryptophan metabolites influence microbial colonization and mediate different signaling pathways to regulate intestinal barrier function.The authors summarize recent findings on the role of tryptophan and its metabolites in enhancing the intestinal mucosal barrier,growth performance,and immune response,aiming to provide new ideas and methods for the application of tryptophan bacterial metabolites in livestock and poultry production.

Key words: tryptophan; bacterial metabolites; intestinal mucosal barrier; growth performance; livestock and poultry

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