成黑色素细胞生成过程中信号调节的研究进展

Abstract

Abstract: Melanocytes synthetise melanin which determine skin and coat color for animals. There are two generate ways about melanoma cells throughout the body. One way is through the retinal pigment epithelial cells which are divided from medullary epithelium cells. The other way is through melanoblasts, in the early embryonic development, neural crest cells differentiate into melanoblast firstly, these cells continue to develop into mature melanocytes. After reviewing on the development of mouse and human genetics, we had proved that it was a complex process of melanin derived from neural crest cells. The development and differentiation of melanocytes were regulated by multiple signaling factors. Among the rest there were some transcription factors SOX10, MITF and PAX3, and three signaling pathways, KIT and KITL, WNT/β-catenin, EDN3 and EDNRB. The MITF was considered as the most important regulatory factor during the development of melanocytes.Three pathways were also considered closing to the development of melanocytes and regulating the function and activity of MITF. This article summarized the research progress on the development of melanocytes and indicated that early developmental regulation of neural crest cells might be the fundamental reason which caused the formation of hyper-pigmentation traits in silky fowl and Black-boned sheep.

Key words: melanocytes; neural crest; signal pathway

CLC Number:

YANG Chun-ling, HAO Tian-tian, LI Qiang-fei, CHEN Ting, MAO Hua-ming, DENG Wei-dong. Signal Regulation for Melanoblast Cytopoiesis Process：A Review[J]. , 2013, 40(9): 187-194.

References

1 Adameyko I, Lallemend F, Aquino J B, et al. Schwann cell precursors from nerve innervation area cellular origin of melanocytes in skin[J]. Cell, 2009, 139(2): 366~379.
2 Aoki H, Motohashi T. Cooperative and indispensable roles of endothelin 3 and KIT signaling in melanocyte development[J]. Dev Dyn, 2005, 233(2): 407~417.
3 Baroffio A, Dupion E, Le Douarin N M. Common precursors for neural and mesectodermal derivatives in the cephalic neural crest[J]. Development, 1991, 112(3): 301~305.
4 Bauer G L, Praetorius C,Bergsteinsdóttir K, et al. The role of MITF phosphorylation site during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue[J]. Genetics, 2009, 183(2): 581~594.
5 Baynash A G, Hosoda K, Giaid A, et al. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons[J]. Cell, 1994, 79(7): 1277~1285.
6 Berstein L M. The effect of physiological doses of thyroxine on the level of cyclic adenosine-3',5'-monophosphate in pituitary and anterior hypothalamus of male rats of different age[J]. Endokrinoloqie, 1980, 75(1): 29~34.
7 Bronner-Fraser M, Garcia-Castro M. Manipulations of neural crest cells or their migratory pathways[J]. Methods Cell Biol, 2008, 87: 75~96.
8 Cable J, Jackson I J, Steel K P. Mutations at the W locus affect survival of neural crsest-derived melanocytes in the mouse[J]. Mech Dev, 1995, 50(2~3): 139~150.
9 Chabot B, Stephenson D A, Chapman V M, et al. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus[J]. Nature, 1988, 335(6185): 88~89.
10 Copeland N G, Gilbert D J, Cho B C, et al. Mast cell growth factor maps ne ar the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles[J]. Cell, 1990, 63(1):175~183.
11 Dehrm V, Beenmann F, Martinozzi S, et al. Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development[J]. Genes Dev, 2007, 21(22): 2923~2935.
12 Dorshorst B, Molin A M, Rubin C J, et al. A complex gemomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chicken[J]. PLoS Genet, 2011, 7(12): 1~3.
13 Dorsky R I, Moon R T, Raible D W. Control of neural crest cell fate by the Wnt signalling pathway[J]. Nature, 1998, 396(6709):370~373.
14 Dorsky R I, Raible D W, Moon R T. Dired regulation of nacre, a zebrafish MITF homolog required for pigment cell formation by the Wnt pathway[J]. Genes Dev, 2000, 14(2): 158~162.
15 Dunn K J, Brady M, Ochsenbauer-Jambor C, et al. WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action[J]. Pigment Cell Res, 2005, 18(3): 167~180.
16 Elena de Bellard M, Bronner-Fraser M. Neural crest migration methods in the chicken embryo[J]. Methods Mol Biol, 2005, 294: 247~267.
17 Gallagher S J, Rambow F,Kumasaka M, et al. Beta-catenin inhibits melanocyte migration but induces melanoma metastasis[J]. Oncogene, 2012, 32(17):2230~2238.
18 Gammill L S, Bromer-Fraser M. Neural crest specification: Migrating into genomics[J]. Nat Rev Neurosci, 2003, 4(10): 795~805.
19 Hachiva A, Sriwiriyanont P,Kobayashi T, et al. Stem cell factor-KIT signaling plays a pivotal role regulating pigmentation in mammalian hair[J]. J Pathol, 2009, 218(1): 30~39.
20 Hall B K. The neural crest in development and evolution[M]. New York: Springer, 1999.
21 Hari L, Miescher I, Shakhova O, et al. Temporal control of neural crest lineage generation by Wnt/β-catenin signaling[J]. Development, 2012, 139(12): 2107~2117.
22 Hemesath T J, Steingrimsson E, McGill G, et al. Microphthalmia a critical factor in melanocyte development, defines a discrete transcription factor family[J]. Genes Dev, 1994, 8(22): 2770~2780.
23 Hemesath T J, Price E R, Takemoto C, et al. MAP kinases links the transcription factor microphthalmia to c-Kit signalling in melanocytes[J]. Nature, 1998, 391(6664): 298~301.
24 Hodgkinson C A, Moore K J, Nakayama A, et al. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-zipper protein[J]. Cell, 1993, 74(2): 395~404.
25 Hosoda K, Hammer R E, Richardson J A, et al. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice[J]. Cell, 1994, 79(7): 1267~1276.
26 Hou L, Takeuchi T. Neural crest development in reptilian embryos, studied with monoclonal antibody, HNK-1[J]. Zool Sci, 1994, 11(3): 423~431.
27 Hou L, Panthier J J, Arnheiter H. Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: Interactions between KIT and MITF[J]. Development, 2000, 127(24): 5379~5389.
28 Hou L, Pavan W J, Shin M K, et al. Cell-autonomous and cell non-autonomous signaling through endothelin receptor B during melanocyte devdopment[J]. Development, 2004, 131(14): 3239~3247.
29 Hou L, Pavan W J. Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development: Do all roads lead to Mitf[J]. Cell Res, 2008, 18(12): 1163~1176.
30 Ikeya M, Lee S M, Johnson J E, et al. Wnt signaling ratuired for expansion of neural crest and CNS progenitors[J]. Nature, 1997, 389 (6654): 966~970.
31 Imokawa G, Kobayasi T, Miyaqishi M. Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes.Cross-talk via trans-activation,of the tyrosine kinase c-kit receptor[J]. J Biol Chem, 2000, 275 (43): 33321~33328.
32 Jin E J, Erickson C A, Takada S, et al. Wnt and BMP signaling govern lineage segregation of melanocytes in the avian embryo[J]. Dev Biol, 2001, 233(1): 22~37.
33 Kitamura Y, Oboki K, Akihiko I. Molecular mechanisms of mast cell development[J]. Immunol Allergy Clin North Am, 2006, 26(3): 387~405.
34 Kunisada T, Yoshida H, Yamazaki H, et al. Transgene expression of steel factor in the basal laye of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors[J]. Development, 1998, 125 (15): 2915~2923.
35 Le Douarin N M, Kalcheim C. The neural crest[M]. Cambridge, Cambridge University Press, 1999.
36 Li A, Ma Y, Yu X, et al. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod-driven motility and cell-cycle progression[J]. Dev Cell, 2011, 21(4): 722~734.
37 Lin J Y, Fisher D E. Melanocyte biology and skin pigmentation [J]. Nature, 2007, 445 (7130): 843~850.
38 Mackenzie M A, Jordan S A, Budd P S, et al. Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo[J]. Dev Biol, 1997, 192 (1): 99~107.
39 Nataf V, Lecoin L, Eichmann A, et al. Endothelin-B receptor is expressed by neural crest cells in the avian embryo[J]. Proc Natl Acad Sci USA, 1996, 93 (18): 9645~9650.
40 Nishikawa S, Kusakabe M, Yoshinaga K, et al. In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody:Two distinct waves of c-kit dependency during melanocyte development[J]. EMBO J, 1991, 10 (8):2111~2118.
41 Ooka S, Kawa Y, Ito M, et al. Establishment and characterization of a mouse neural crest derived cell line (NCC melan5)[J]. Pigment Cell Res, 2001, 14(4): 268~274.
42 Paulhe F, Imhof B A, Wehrle-Haller B. A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface[J]. J Biol Chem, 2004, 279(53): 55545~55555.
43 Pingault V, Bondurand N, Kuhlbtodt K, et al. SOX10 mutations in patients with Waardenburg-Hirschspung disease[J]. Nat Genet, 1998, 18(2): 171~173.
44 Pla P, Albert C, Solovva O, et al. Ednrb2 orients cell migration towards the dorsolateral neural crest pathway and promotes melanocyte differentiation[J]. Pigment Cell Res, 2005, 18(3): 181~187.
45 Potterf S B, Furumura M, Dunn K J, et al. Transcription factor hierarchy in Waardenburg syndrome: Regulation of MITF expression by SOX10 and PAX3[J]. Hum Genet, 2000, 107(1):1~6.
46Puffenberger E G, Hosoda K, Washington S S, et al. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease[J]. Cell, 1994, 79(7): 1257~1266.
47 Roelink H, Nusse R. Expression of two members of the Wnt family during mouse development-restricted temporal and spatial patterns in the developing neural tube[J]. Genes Dev, 1991, 5(3): 381~388.
48 Sato S, Roberts K, Gambino G, et al. CBP/p300 as a co-factor for the microphthalmia transcription factor[J]. Oncogene, 1997, 14(25): 3083~3092.
49 Schepsky A, Bruser K,Gunnarsson G J, et al. The microphthalmia-associoted transcription factor Mitf interacts with beta-catenin to determine target gene expression[J]. Mol Cell Biol, 2006, 26(23): 8914~8927.
50 Shin M K, Levorse J M, Ingram R S, et al. The temporal requirement for endothelin receptor-B signaling during neural crest development[J]. Nature, 1999, 402(6761): 496~501.
51 Southard-Smith E M, Kos L, Pavan W J. Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model[J]. Nat Genet, 1998, 18(1): 60~64.
52 Tachibana M, Takeda K, Nobukuni Y, et al. Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics[J]. Nat Genet, 1996, 14(1): 50~54.
53 Thomas A J, Efickson C A. The making of a melanocyte: The speccifcation of melanoblasts from the neural crest[J]. Pigment Cell Melanoma Res, 2008, 21(6): 598~610.
54 Tsujimura T, Morii E, Nozaki M, et al. Involvement of transcription factor encoded by the milocus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice[J]. Blood, 1996, 88(4): 1225~1233.
55 Wehrle-Haller B. The role of Kit-ligand in melanocyte development and epidermal homeostasis[J]. Pigment Cell Res, 2003, 16(3): 287~296.
56 Wehrle-Haller B, Weston J A. Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway[J]. Development, 1995, 121(3): 731~742.
57 Xu W, Gong L, Haddad M M, et al. Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9[J]. Exp Cell Res, 2000, 255(2): 135~143.
58 Yamada T, Akamatsu H,Hasegawa S, et al. Melanocyte stem cells express receptors for canonical Wnt-signaling pathway on their surface[J]. Biochem Biophys Res Commun, 2010, 396(4): 837~842.
59 Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells[J]. Nature, 1988, 332(6163): 411~415.
60 Yasumoto K, Takeda K, Saito H, et al. Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling[J]. EMBO J, 2002, 21(11): 2703~2714.
61 Yoshida H, Kunisada T, Kusakabe M, et al. Distinct stages of melanocyte differentiation revealed by analysis of nonuniform pigmentation patterns[J]. Development, 1996, 122(4): 1207~1214.

[1]	ZAN Gengxiu, QIN Yingchao, ZHU Chao, WANG Xiuqi. Research Progress of JAK/STAT Signal Pathway Regulating Intestinal Mucosal Regeneration and Helper T Cell Response [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2079-2087.
[2]	LI Qilong, CHEN Xiangnan, LONG Feng, CHEN Jiayue, YANG Sen, WANG Jing, ZAN Linsen, CHENG Gong. Research Progress in Function of Snail Family Genes [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1287-1294.
[3]	JI Wenhui, WANG Yuling, HE Honghong, FU Wei, LAN Daoliang. Effects of Vitamin A on the Maturation and Subsequent Development of Yak Oocytes in vitro [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(12): 4707-4714.
[4]	DONG Bowen, CUI Xiaozhen, BAI Rui, ZHENG Mingxue, ZHANG Li, LYU Xiaoling, REN Yuhong. Effects of EGF and FGF-2 on Proliferation and Differentiation of Porcine Subcutaneous Adipose Neural Crest Stem Cells [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(12): 4878-4886.
[5]	ZHU Jiawei, ZHAO Xiaohan, MA Cui, TANG Chaohua, SI Wei, ZHAO Qingyu, ZHANG Junmin, QIN Yuchang. GPX4 Inactivation Alleviates LPS-induced Macrophage Inflammatory Response via JNK Pathway [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4178-4186.
[6]	LIU Haixia, ZHU Aiwen, WANG Buzhong, GENG Xinzhi, ZHENG Ankang. Research Progress on Mechanism of Melanin Deposition and Related Candidate Genes in Black-bone Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(12): 4588-4596.
[7]	TAO Zhiyun, ZHU Chunhong, SHI Zuhao, XU Wenjuan, ZHANG Shuangjie, SONG Weitao, LIU Hongxiang, LI Huifang. Effect of Riemerella anatipestifer on the Morphological Structure and TLR4 Signal Pathway Related Gene Expression of Cecum in Ducks [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(6): 1702-1708.
[8]	DOU Caixia, WANG Qian, AN Jianyong, QIAO Jiayun. The Reasearch Progress of Keap1-Nrf2/ARE Signaling Pathway and Its Role in the Antioxidation of Livestock and Poultry [J]. China Animal Husbandry and Veterinary Medicine, 2019, 46(9): 2567-2574.
[9]	XIONG Heli, XI Dongmei, LI Guozhi, WANG Liping, LIU Xiangying, YUAN Mengya, LI Jing, DENG Weidong. Research Advances on the Formation Mechanism of Animal Melanocytes and Its Related Traits [J]. , 2019, 46(1): 72-79.
[10]	YANG Yu-jing, NIE Rui-qiang, XIE Jian-shan, FAN Rui-wen, DONG Chang-sheng. Cloning and Bioinformatics Analysis on CDS of Oct-1 Gene in Mouse [J]. , 2016, 43(8): 1960-1966.
[11]	WANG Xiao-jia, HE Jian-ning, LIU Nan. Research Progress on EDA Gene and its Role in the Development of Animal Hair Follicle [J]. , 2015, 42(7): 1777-1786.
[12]	BAI Man, ZHAO Jia, ZHAN Wei, SUN Li-min, JIANG Huai-zhi. Research Progress on Adiponectin and its Receptors and their Roles in Reproduction [J]. , 2015, 42(7): 1830-1835.
[13]	LIU Zhen, ZHAO Hai-ping, YANG Chun, CHU Wen-hui, WANG Da-tao, LI Chun-yi. Research Progress on Antler Regeneration and its Molecular Regulate [J]. , 2013, 40(2): 50-53.
[14]	WEN Jing;FU Shou-peng;LIU Ju-xiong. Research Progress on the Roles of β-hydroxybutyric Acid Played in Central Nervous System and Mechanism [J]. , 2012, 39(2): 106-110.
[15]	LI Wen-qing, WANG Jia-qi, NAN Xue-mei, SUN Peng. Research Progress on Genes and Signal Pathways Associated with Lactose Synthesis and Lactation in Dairy Cows [J]. , 2012, 39(11): 104-110.

Signal Regulation for Melanoblast Cytopoiesis Process：A Review

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments