类固醇激素在子宫内膜过度增生中的作用机理

doi:10.16431/j.cnki.1671-7236.2023.09.021

Abstract

Abstract: Endometrial hyperplasia is a common uterine disease in females,which can cause various degrees of functional uterine bleeding,embryo implantation failure and postmenopausal vaginal bleeding.It has a negative impact on reproduction and has the risk to develop endometrial cancer.Steroid hormones,including estrogen,progestogen,and androgens,play important roles in endometrial hyperplasia.High concentrations of estrogen or long-term low concentration of estrogen stimulation without progesterone resistance is the main cause of endometrial hyperplasia.Androgens,similar with progesterone,has an antiestrogen effects.Pregnant mare serum gonadotropin,a reproductive hormone commonly used in fix-timed insemination,can significantly increase the number of ovulations,while cause excessive endometrial hyperplasia by promoting ovarian estradiol secretion.The role and mechanism of steroid hormones in endometrial hyperplasia remains unknown.The review introduces the types of endometrial hyperplasia,the research progress of endometrial hyperplasia in different animals,and the role and mechanism of steroid hormones on endometrial hyperplasia,the influence of other factors and genes on endometrial hyperplasia and the prevention and treatment of endometrial hyperplasia,in order to provide theoretical references for the prevention and treatment of endometrial hyperplasia in animals.

Key words: endometrial hyperplasia; steroid hormone; steroid hormone receptor; signal pathway

CLC Number:

S814.1

LI Lu, GU Zhenhui, FENG Tao, WANG Hongna. Role and Mechanism of Steroid Hormones in Endometrial Hyperplasia[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(9): 3652-3662.

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Role and Mechanism of Steroid Hormones in Endometrial Hyperplasia

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