EDA基因及其信号通路在动物皮肤毛囊发育中作用研究进展

doi:10.16431/j.cnki.1671-7236.2015.07.023

Abstract

Abstract: Mutations of the ectodysplasin-A (EDA) gene cause reduction or absence of many ectodermal appendages,such as hair,teeth,sweat glands,sebaceous glands and mammary glands,requires the action of EDA.EDA signal pathway affects the initiation of several hair follicle (HF) types,hair shaft formation,as well as sebaceous gland morphology,it is involved in the control of cell fate decision in embryonic epidermis,as well as in the regulation of cell differentiation programs in the HF.This paper summarized the relationship between EDA signal pathway and animal HF development.The main content was as follows: Firstly,the functions of EDA gene and structure of EDA protein,its two main functional splice variants EDA1 and EDA2's functions and mechanism of action,EDA1-EDAR system plays a predominant role in the development of skin-derived structures,EDA1 and EDAR's mutations all can cause hypohidrotic ectodermal dysplasia (HED);Secondly,the regulation mechanisms of the EDA and its pathway to the HF development,and also the relationship between EDA and other pathways,studies suggested the involvement of EDA signal in control of anagen-catagen transition,it is also involved in hair cycle control and regulates apoptosis in HF keratinocytes during catagen.The EDA-EDAR system is an important effector of canonical Wnt signal in developing skin appendages,it would then occur directly downstream of the induction signal.The EDA signal pathway relies on downstream NF-κB pathway activation to regulate target genes,it functions by stimulating NF-κB-mediated transcription of effectors or inhibitors of the Wnt,sonic hedgehog (SHH),fibroblast growth factor (FGF) and transforming growth factor beta (TGF-β) pathways that regulate interactions within or between epithelial and mesenchymal cells and tissues.From above,we conclude that EDA and its signal pathway take part in the regulation of HF cell development and differentiation,they play important role in animal follicle growth and development.

Key words: EDA gene; signal pathway; hair follicle; development

CLC Number:

S814.8

WANG Xiao-jia, HE Jian-ning, LIU Nan. Research Progress on EDA Gene and its Role in the Development of Animal Hair Follicle[J]. , 2015, 42(7): 1777-1786.

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Research Progress on EDA Gene and its Role in the Development of Animal Hair Follicle

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