维甲酸诱导蛋白Ⅰ在禽类抗病毒天然免疫中的研究进展

Abstract

Abstract: Retinoic acid-inducible geneⅠ(RIG-Ⅰ) is a key innate immune pattern-recognition receptor that triggers type Ⅰ interferon, cytokine and chemotactic factor expression upon detection of intracellular double-strand RNA of viral origin. It plays an important role in the constructing of antiviral innate immunity. Researches on the mammal show that RIG-Ⅰ takes part in the inhibition of AIV, NDV,and so on. RIG-Ⅰ is absent in chickens and duck RIG-Ⅰ can initiate an antiviral IFN response in chicken cell line. This review provided an overview of mechanism of RIG-Ⅰ activation with an expanded discussion on the potentials of improving avian antiviral ability and enhancing basis researches of avian innate immunity.

Key words: retinoic acid-inducible geneⅠ; avian; innate immunity; antivirus

CLC Number:

S852.4

ZHANG Ya-chun, WANG Wei, MENG Qing-wen. Research Progress of RIG-Ⅰ in Avian Antiviral Innate Immunity[J]. , 2013, 40(8): 169-172.

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Research Progress of RIG-Ⅰ in Avian Antiviral Innate Immunity

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