IL-17细胞因子家族调节黏膜免疫的研究进展

Abstract

Abstract: Cutaneous and mucosal epithelial cells are a physical barrier and the first defense line of host against environmental changes. The crosstalk between epithelial cells, dendritic cells (DCs) and leukocytes play an important role in inducing proper immune responses during host defense. Interleukin-17 (IL-17) family cytokines are cytokines discovered recently, playing important roles as powerful pro-inflammatory cytokines. They are important players in innate and adaptive immune response of host. IL-17A, IL-17C and IL-17F can directly target tissue epithelial cells to induce various antimicrobial responses against extracellular pathogens and promote tissue remodeling. By contrast, IL-17E primarily acts on leukocytes and induces type Ⅱ immunity that is crucial for protection against parasites. IL-17E also negatively regulates IL-17A and IL-17F production from leukocytes while reports are less on IL-17B and IL-17D.

Key words: interleukin-17 (IL-17) cytokine; mucosal; epithelial cells; leukocytes; dendritic cells (DCs)

CLC Number:

S392.12

GUO Feng, LIU Yu, FU Zhi-ling, YANG Yan-hong, LI Wei, ZHAO Xue, ZHENG Xin. Research Progress on Regulation Mucosal Immune of IL-17 Cytokine Family[J]. , 2013, (5): 140-143.

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Research Progress on Regulation Mucosal Immune of IL-17 Cytokine Family

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