JAK-STAT信号通路研究进展

Abstract

Abstract: JAK-STAT signaling pathway involved in various of physiological and pathological responses. JAK kinases were activated after the binding of cytokines to their corresponding receptors, further phosphorylation of STATs were produced which result in homologous or heterologous dimerization, the dimeric protein then translocated into the nucleus and binding the promoters of relevant target genes for the controlling of expression of objective proteins. Consequently, the pathway plays an momentous role in the regulationg of organisms.

Key words: signaling pathway; JAK-STAT; transduce

CLC Number:

SONG Zhou, ZHANG Li-yan, DONG Hai-bing, BAI Huan-li, CHEN Wei, WU Shuai-cheng, YI Peng-fei, FU Ben-dong, SHEN Hai-qing, WEI Xu-bin. Advances in JAK-STAT Signaling Pathway[J]. , 2012, 39(6): 128-132.

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