取代基对黄酮类化合物抑制脂多糖诱导巨噬细胞释放一氧化氮活性的影响

Abstract

Abstract: Aim to provide experimental data for the research and development of flavonoids as non-steroidal anti-inflammatory drugs (NSAIDS),the substituent effects on the anti-inflammatory effect of five flavonoids against lipopolysaccharide (LPS)-induced nitric oxide (NO) have been studied. Flavone (FLA),5,7-dihydroxyflavone (DFL),5,7,4'-trihydroxyflavone (TFL),apigenin-7-glucoside (APG) and linarin (LIN) were carried out to investigate for anti-inflammatory effects against LPS-induced NO. TFL significantly inhibited generation of NO on LPS stimulated RAW264.7 cells. The 4'-OH was essential for the anti-inflammatory effect of TFL against LPS-induced NO.

Key words: flavonoids; 4'-Trihydroxyflavone; macrophage; NO

CLC Number:

S859.7

YANG Yao-zhi;TANG You-zhi;CHEN Jian-xin. Influence of Substituent on the Anti-inflammatory Effect of Flavonoids against Lipopolysaccharide-induced Nitric Oxide[J]. , 2012, 39(5): 107-110.

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Influence of Substituent on the Anti-inflammatory Effect of Flavonoids against Lipopolysaccharide-induced Nitric Oxide

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