PLGA纳米粒及其在生物医学领域的应用潜力

doi:10.16431/j.cnki.1671-7236.2024.01.004

Abstract

Abstract: Polylactic-co-glycolic acid (PLGA) is a polymer composed of lactic acid and glycolic acid, which has good biodegradability and biocompatibility, as a new carrier and delivery system, and is widely used in biology, medicine and other fields.PLGA has the functions of antigen display and antigen encapsulation, which can protect and encapsulate a series of substances including bioactive compounds (such as protein and peptides), nucleic acids and immunomodulatory molecules from protease-mediated mucosal surface degradation, and can also slowly release drugs or antigens to reduce the times of immunization and medication, so it has great application potential in the treatment of intestinal diseases.In addition, drugs or antigens can be coupled to the surface of PLGA particles to display antigens, which shows excellent characteristics in vaccine development and drug preparation.PLGA can also be used as an adjuvant to enhance the immune protection effect of the vaccine.The surface modification function of PLGA can be used for targeted drug delivery.Targeted delivery of therapeutic molecules to specific parts of the body can not only reduce adverse side effects, but also increase the concentration of local raw materials to improve drug efficacy.PLGA nanoparticles can be loaded with different types of drugs individually or jointly, with low immunogenicity, and they are easy to be regulated by controlled chemical synthesis.Therefore, PLGA is widely used as a non-viral gene delivery system and drug delivery platform with great application potential in biomedical field.This paper focuses on reviewing the structural characteristics and preparation methods of PLGA nanoparticles, as well as the research progress and application prospects of PLGA-based prepared nanocarrier platforms in the fields of vaccine development and drug delivery, aiming to provide a reference for the related research of PLGA nanoparticles.

Key words: polylactic-co-glycolic acid (PLGA); antigen display; nanoparticles; biomedicine

CLC Number:

S859.79

WANG Xiaofang, FU Le, ZHANG Panpan, ZHANG Huaying, JU Qing, WANG Yawen. PLGA Nanoparticles and Its Application Potential in the Field of Biomedicine[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(1): 33-41.

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PLGA Nanoparticles and Its Application Potential in the Field of Biomedicine

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