生长激素释放肽及其生物学效应

Abstract

Abstract: Ghrelin, a peptide lying widely in animal bodies, is the endogenous ligand for the growth hormone secretagogue receptor(GHSR). Ghrelin, after binding with GHSR in the hypothalamus and pituitary, not only promotes the GH releasing and increases appetite, but also adjusts the functions of digestive system and energy metabolism. This article mainly reviewed the recent developments on structure, distribution and biological effects of ghrelin as well as its potential applications in animal husbandry, which maybe promotes the further research of ghrelin.

Key words: Ghrelin; growth hormone secretagogue; biological function; outlook

CLC Number:

S852.2

LAI Jing-hui, FAN Hong-jie. Recent Advances in Studies on Ghrelin and its Biological Functions[J]. , 2012, 39(11): 66-69.

References

1 支星,魏杰. Ghrelin与生殖系统研究进展[J]. 生理科学进展,2011,42(4):307~310.
2 王娜, 吴立玲. Ghrelin对消化系统功能的调节[J].生理科学进展,2007,3: 242~244.
3 邓雪娟,蔡辉益,李宗付.生长素及其在动物生产中的应用[J].畜牧兽医杂志,2007,26(3):45~47.
4 刘贤英,张甲生,李东复. 生长激素释放肽与消化系统功能及相关疾病的研究进展[J].第四军医大学学报,2009,30(23):2892~2894.
5 陈斌,吴天星. Ghrelin生物学功能的研究进展[J].中国畜牧杂志,2005,41(10):64~67.
6 韩延柏,汪宏莉,刘宇,等. 血清生长激素释放肽水平与代谢综合征关系[J].中国公共卫生,2011,27(6):760~761.
7 Bassil A K, Dass N B, Sanger G J. The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurons[J].European Journal of Pharmacologyl, 2006, 544: 146~152.
8 Broglio F, Gottero C, Arvat E, et al. Endocrine and non-endocrine actions of ghrelin[J]. Hormone Research, 2003, 59(3): 109~117.
9 Date Y, Murakami N, Kojima M, et al. Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rates[J]. Biochemical and Biophyical Research Communications, 2000, 275: 477~480.
10 Hosoda H, Kojima M, Matsuo H, et al. Ghrelin and Desacyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue[J]. Biochemical and Biophyical Research Communications, 2000, 279: 909~913.
11 Kojima M, Hosoda H, Date I, et al. Ghrelin is a growth hormonereleasing acylated peptide from the stomach[J].Nature, 1999, 402: 656~660.
12 Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding[J]. Nature, 2001, 409: 194~198.
13 Pulkkinen L, Ukkola O, Kolehmainen M, et al. Ghrelin in diabetes and metabolic syndrome[J]. International Journal of Peptide Research and Therapeutics,2010,4(27):1~11.
14 Sato M, Nakahara K, Goto S, et al. Effects of ghrelin and desacyl ghrelin on neurogenesis of the rat fetal spinal cord[J]. Biochemical and Biophyical Research Communications, 2006, 350: 598~603.
15 Tomasz B, Peter C K, Zbigniew S, et al. Prostaglandin/clooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury[J]. The Journal of Pharmacology and Experimental Therapeutics,2006,319:477~487.
16 Tack J, Depoortere I, Bisschops R, et al.Influence of ghrelinon interdigestive gastrointestinal motility in humans[J]. [JP]Gut, 2006, 55: 327~333.
17 Takaya K, Ariyasu H, Kanamoto N, et al. Ghrelin strongly stimulates growth hormone release in humans[J]. The Journal of Clinical Endocrinology Metabolism, 2000, 85: 4908~4911.
18 Trudel L, Tomasetto C, Rio M C, et al. Ghrelin motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat[J].American Journal of Physiology Gastrointestinal Liver Physiology,2002,282:G948~G952.
19 Tschöp M, Smiley D L, Heiman M L. Ghrelin induces adiposity in rodents[J]. Nature, 2000,7: 908~913.
20 Xu L, Depoortere I, Tomasetto C, et al. Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus[J]. Regulatory Peptides, 2005, 124: 119~125.

[1]	CHEN Jun, CAI Haiming, LIAO Shenquan, QI Nanshan, LI Juan, LYU Minna, LIN Xuhui, HU Junjing, ZHANG Jianfei, LIU Wenjun, SUN Mingfei. Review on the Research of DNA Helicase Family in Parasitic Protozoa [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 317-327.
[2]	LI Qilong, CHEN Xiangnan, LONG Feng, CHEN Jiayue, YANG Sen, WANG Jing, ZAN Linsen, CHENG Gong. Research Progress in Function of Snail Family Genes [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1287-1294.
[3]	WEI Wenzhuo, LIANG Zhenhua, WU Yan, LIU Jingbo, PI Jinsong, ZHANG Hao. Effects of Exosomes on Animal Intestinal Health and Its Research Methods [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 579-586.
[4]	JIA Wenqian, ZHUANG Zhong, BAI Hao, WANG Zhixiu, CHANG Guobin, CHEN Guohong, JIANG Yong. Research Progress on Threonine in Pekin Duck [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4197-4206.
[5]	WANG Peiyi, LIU Xian, ZHANG Zijing, YANG Peng, YAO Zhi, SONG Xingya, WANG Haoran, ZHANG Jiaqiang, LEI Chuzhao, CHEN Hong, HUANG Yongzhen. Biological Function of Exosome and Its Application in Animal Genetics and Breeding [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(7): 2539-2548.
[6]	CHANG Huaxiang, LI Xiaobin, XIONG Suyu, ZHANG Junyu, CHEN Kaixu, LIU Jiancheng, LI Ning, ZANG Changjiang, LI Fengming. Proteome Identification and Potential Function Analysis of Milk Fat Globule Membrane in Horses [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(11): 4025-4034.
[7]	ZHANG Shaotao, LI Min, XIE Yuhuai, CHENG Zhenfeng, YANG Weiren. The Biological Function of Selenomethionine and Its Application in Pigs Production [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(9): 2824-2832.
[8]	WU Dongwang, SUN Liyuan, YUAN Zaimei, HE Shichun, HU Chenglong, DENG Mingyue, MAO Huaming, YANG Shuli. Research Progress on Animal DGAT Gene [J]. , 2019, 46(7): 1945-1952.
[9]	GAO Shan, GUO Yong, CHEN Yu, QI Xiaolong. Biological Function of Natural Astaxanthin and Its Application in Animal Production [J]. China Animal Husbandry and Veterinary Medicine, 2019, 46(10): 2981-2987.
[10]	WANG Lingling, SUN Guopeng, XU Ruonan, HE Haixun, YAN Zhanpeng, WANG Yaping, XING Ruilin, REN Pengju, LI Peng, ZHANG Yanfang, ZHU Yanping, YUE Feng, WANG Xuannian. Study on Preparation and Biological Function of Chicken PD-1 Monoclonal Antibody [J]. , 2018, 45(12): 3363-3370.
[11]	CHEN Zhong-jian, WU Xiu-ju, ZHU Cui, ZHANG Wei-na, LIANG Rui, YAN Shi-juan, SU Hao-xian, CHEN Zhuang. Distribution of 5-hydroxytryptamine, Ghrelin or Glucagon-like Peptide-1 Immunopositive Cells in the Gastrointestinal Tract of Meihua Pig [J]. , 2017, 44(5): 1498-1507.
[12]	LU Qi-rong, LIU Meng-ke, LI Li, CHENG Gu-yue, HAO Hai-hong, WANG Xu, DAI Meng-hong, YUAN Zong-hui. Function and Research Methods of Long Noncoding RNA in Livestock and Poultry [J]. , 2016, 43(9): 2425-2434.
[13]	JIA Sheng-jun, ZHAO Jiao, LI Na. Biological Functions of TLRs in Mammalian Ovulation Processes [J]. , 2016, 43(6): 1591-1596.
[14]	MA Xiao-meng, ZHANG Li, DU Li-xin. Research Progress on MEF2B Gene in Human and Animals [J]. , 2015, 42(5): 1116-1122.
[15]	FAN Xing-xing, LI Xin-jian, GUO Ji-li, LI Gai-ying, LV Gang, REN Guang-zhi. Research Progress of Fosl2 Gene [J]. , 2014, 41(8): 80-84.

Recent Advances in Studies on Ghrelin and its Biological Functions

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments