外泌体的生物学功能及其在动物遗传育种中的应用

doi:10.16431/j.cnki.1671-7236.2021.07.030

Abstract

Abstract: Exosomes are vesicles widely existed in the intercellular substance of various cells.Exosomes can be produced by various kinds of cells under normal conditions or under stress conditions such as extracellular stimulation.The action mode and functions of exosomes derived from different cell-types are different.Exosomes can transmit bioactive molecules to participate in the process of body immunity and cell differentiation by binding membrane proteins to target cell membrane proteins,binding membrane protein fragments to receptors on cell membrane,and direct fusion between membrane and target cell membrane.Exosomes with the characteristics of natural origin,good barrier crossing capability and excellent biocompatibility have attracted much attention in many fields.The morphological characteristics,formation process,mechanism of action,isolation and purification,biological characteristics,function and application of exosomes were introduced and the application of exosomes applied to livestock and poultry research in recent years were summarized in this paper.Exosomes can not only be used in animal genetics and breeding,but also be used as tools or carriers to study multiple biochemical pathways in animals.This review can provide references for the research and application of exosomes.

Key words: exosomes; action mode; biological function; animal genetics and breeding

CLC Number:

WANG Peiyi, LIU Xian, ZHANG Zijing, YANG Peng, YAO Zhi, SONG Xingya, WANG Haoran, ZHANG Jiaqiang, LEI Chuzhao, CHEN Hong, HUANG Yongzhen. Biological Function of Exosome and Its Application in Animal Genetics and Breeding[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(7): 2539-2548.

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Biological Function of Exosome and Its Application in Animal Genetics and Breeding

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