Abstract: To explore the effects of swine plague antibody which was induced by swine plague vaccine in astragalan adjuvant on piglets. 40 piglets were randomly divided into 4 groups (n=10), those groups were respectively normal sodium (NS) group, swine plague vaccine (SPV) group, astragalan injection (AGI) group and astragalan injection-swine plague vaccine (AGI-SPV) group. They were respectively injected drugs into musculi colli on the 20^th day and 85^th of piglets were born after were taken suction blood (5 mL) for detection from precaval vein, such as the NS 3 mL was injected for 3 d, SPV 1 mL for 1 d and NS 3 mL for 2 d, AGI 10 mg/kg for 3 d, AGI 10 mg/kg for 3 d with the SPV 1 mL for 1 d,and then they were accordingly taken suction blood on the 35^th and 100^th day for detecting the IgG, IgM, IgA, γ-Globulin (γ-G) and swine plague antibody(SP-Ab) and so on. Those γ-G, IgG, IgM and IgA of the AGI group and AGI-SPV group are significantly higher than the NS group and the SPV group (P＜0.05); the blocking rate of swine plague antibody of SPV group and the AGI-SPV group are significantly higher than themselves on the 35^th and 20^th day, as well the AGI-SPV group is higher than the SPV group, too. The AGI can be used for immunologic adjuvant for improving immunity of piglets on swine plague vaccine, the mechanism of action might be concerned with raising the immunoglobulin and facilitating the swine plague antibody-formaing.

Key words: swine plague vaccine; astragalan; immunity; effect