Abstract: Recently the drug resistance of pathogens in food has arisen attention. To analyze the drug resistance of Salmonella spp. in animal food in Sichuan，76 strains isolated from animal food in Sichuan were tested against 25 antibiotics using broth micro-dilution method. Among 76 Salmonella strains，96.05%，78.95%，64.47%，60.53%，60.53%，56.58%，53.95% and 52.63% were resistant to Rifampin， Polymyxin E， Sulfisoxazole， Cephazolin， Ampicillin， Amoxicillin-Clavulanic， Trimethoprim and Doxycycline， respectively, and displayed different resistance rates to the rest drugs. There was a total of 66 kinds of resistance spectrum and the rate of multi-drug resistance was 97.37%(74/76). The whole strains demonstrated multi-drug resistance mainly to Penicillins， Cephazolin， Streptomycin，Tetracyclines， Sulphonamides and Polymyxin E. The drug resistance of Salmonella spp. from foods of animal origin in Sichuan was comparatively serious，so we must monitor it continuously and pay more attention to it.

Key words: Salmonella; drug resistance; animal food