›› 2011, Vol. 38 ›› Issue (1): 42-46.

• 生理生化 • Previous Articles     Next Articles

Development of Mannose-binding Lectin-associated Serine Protease 1

ZHANG Hai-yan1,2，WANG Chang-fa2，ZHONG Ji-feng2，YANG Gui-wen1，AN Li-guo1   

  1. (1.College of Life science,Shandong Normal University,Jinan 250014,China;2.Dairy Cattle Research Center,Shandong Academy of Agricultural Sciences，Jinan 250100, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2011-01-01 Published:2011-01-01
  • Contact: AN Li-guo

Abstract: The mannose-binding lectin pathway is an important pathway of complement activation. In the absence of specific immune responses in vivo or before immune response occurs in body the lectin complement pathway may play a major role in the defense. Mannose-binding lectin-associated serine protease-1 (MASP-1) is an central protease of the complement lectin pathway.Mannose-binding Lectin (MBL) or ficolin can form compound with Mannose-binding lectin-associated serine protease (MASPs) through its CLR.After its CRD domain recognize and binding to sugars presented on pathogens, MBL or ficolin can activity the zymogens of MASPs,then activate the complement cascade via lectin pathway to play the function of anti-infection by innate immunity.

Key words: complement; MBL-associated serine protease-1; structure; function

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