磺胺二甲嘧啶生理药动学模型种间类推的应用

Abstract

Abstract: The objective of this paper was to predict kinetic process of Sulfamethazine in sheep on the basis of the physiologically based pharmacokinetic model of Sulfamethazine in pig.The PBPK model in pig was extrapolated to sheep based on the interspecies scaling theory, to simulate the plasma and tissues concentration of Sulfamethazine and estimate residue withdrawal times in edible tissues in sheep. The results showed that the simulated withdrawal times was according to the reported withdrawal times. The interspecies extrapolation of PBPK model was feasible.

Key words: Sulfamethazine; physiologically based pharmacokinetic model; sheep

CLC Number:

S859.7

LUO Xian-yang;YUAN Li-guo. The Interspecies Extrapolation of Sulfamethazine Physiologically Based Pharmacokinetic Model[J]. , 2010, 37(3): 194-197.

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The Interspecies Extrapolation of Sulfamethazine Physiologically Based Pharmacokinetic Model

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