›› 2009, Vol. 36 ›› Issue (3): 80-83.

• 生理生化 • Previous Articles     Next Articles

Effect of Astragalus Polysaccharides on Proliferation of Rat Intestinal Mucosa Microvascular Endothelial Cells in vitro

ZHANG Lei1, HU Ge1, SUO Zhan-wei1, DUAN Hui-qin1, YI Peng-fei2, HU Yi-yi3, MU Xiang1,4   

  1. (1.Department of Animal Science and Technology, Beijing Agricultural College, Beijing 102206, China; 2.Institute of Animal Husbandry and Veterinary Medicine, Jilin University, Changchun 130062, China; 3.Institute of Traditional Chinese Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; 4.Beijing Key Laboratory of Veterinary Medicine (Traditional Chinese Medicine and Pharmacology), Beijing Agricultural College, Beijing 102206, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-03-20 Published:2009-03-20
  • Contact: MU Xiang

Abstract: To study the effects of astragalus polysaccharides (APS) on the proliferation in culture of rat intestinal mucosa microvascular endothelial cells (RIMMVECs). RIMMVECs were incubated with different concentrations of APS. The cell morphology was observed and cell proliferation ability was determined by MTT. The proliferation of RIMMVECs was lower (P<0.05 or 0.01) when APS was between 3.2×103 and 25.6×103 mg/L, and higher (P<0.05 or 0.01) when APS was between 25 and 800 mg/L. There was no obvious change in proliferation when treated with 1.6×103 mg/L APS. APS may stimulate the proliferation of cultured RIMMVECs. It plays an important role in protection from injury of RIMMVECs and accelerating its repairing.

Key words: astragalus polysaccharides; microvascular endothelial cells; proliferous effect

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