大肠杆菌K1侵袭血脑屏障的研究进展

doi:10.16431/j.cnki.1671-7236.2017.03.010

Abstract

Abstract:

E.coli K1 strain is a representative strain of neonatal sepsis and meningitis, which causes disease by blood circulation to the brain. The molecular mechanism of E.coli K1 that adhering and invading the brain microvascular endothelial cells (BMECs) and cross the blood brain barrier (BBB) has been focused on by many scholars. In this review, we focused on the gene regulation mechanisms and signaling pathway of E.coli K1 crossing the blood brain barrier to understand the molecular mechanism of the infection caused by E.coli and provide reference for prevention and treatment programs.

Key words: Escherichia coli; meningitis; invasion; human brain microvascular endothelial cells (HBMECs); blood-brain barrier

CLC Number:

R378.2⁺1

LING Chen, ZHANG Qi-wen, SONG Kang, JIANG Jian-jun, YAN Gen-qiang. Research Advances in Escherichia coli K1 Penetration Across Blood-brain Barrier[J]. , 2017, 44(3): 686-691.

References

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Research Advances in Escherichia coli K1 Penetration Across Blood-brain Barrier

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