Abstract: Prion was nerve recessive encephalopathy of human and other mammal, which was one of the hot point in the world. It was said the pathogenic of the disease was the protein, which had same first structure with the normal protein coded by the host, just had different conformation of the second structure. Now it is not clear for the mechanism of the disease. So the author reviews the relation of the prion toxicity and GPI according to the report of other people who research the prion.

Key words: prion; GPI; PrPc; PrPsc; mechanism