制备双特异性单克隆抗体的方法

›› 2007, Vol. 34 ›› Issue (4): 49-52.

• 生物技术 • Previous Articles Next Articles

Methods to Prepare Bispecific Monoclonal Antibodies

LIU Qingtao1,TAN Changjiang2,PAN Zhizhong1,ZANG Li1,ZHANG Naisheng1

1.College of Animal Science and Veterinary Medicine in Jinlin University,Changchun 130062，China； 2.Animal Supervision Station of Epidemic Prevention in Seventh Class,Jimo 266233，China

Received:1900-01-01 Revised:1900-01-01 Online:2007-04-20 Published:2007-04-20

Abstract

Abstract: Bispecific monoclonal antibodies have drawn considerable attention from the research community due to their unique structure against two different antigens. The two-arm structure of BsMAb allows researchers to place a therapeutic agent on one arm while allowing the other to specifically target the disease site.The therapeutic agent can be a drug, toxin, enzyme, DNA, radionuclide, etc. Furthermore,bsMAb may redirect the cytotoxicity of immune effector cells toward the diseased cell or induce a systemic immune response against the target. This review focuses on therapeutic applications and production of bsMAb while providing the up-to-date clinical trial information.

Key words: bispecific monoclonal antibodies; preparation; methods

CLC Number:

S852.4

LIU Qingtao;TAN Changjiang;PAN Zhizhong;ZANG Li;ZHANG Naisheng. Methods to Prepare Bispecific Monoclonal Antibodies [J]. , 2007, 34(4): 49-52.

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Methods to Prepare Bispecific Monoclonal Antibodies

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