China Animal Husbandry & Veterinary Medicine ›› 2007, Vol. 34 ›› Issue (4): 49-52.

• 生物技术 • Previous Articles     Next Articles

Methods to Prepare Bispecific Monoclonal Antibodies

LIU Qingtao1,TAN Changjiang2,PAN Zhizhong1,ZANG Li1,ZHANG Naisheng1
   

  1. 1.College of Animal Science and Veterinary Medicine in Jinlin University,Changchun 130062，China； 2.Animal Supervision Station of Epidemic Prevention in Seventh Class,Jimo 266233，China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-20 Published:2007-04-20

Abstract: Bispecific monoclonal antibodies have drawn considerable attention from the research community due to their unique structure against two different antigens. The two-arm structure of BsMAb allows researchers to place a therapeutic agent on one arm while allowing the other to specifically target the disease site.The therapeutic agent can be a drug, toxin, enzyme, DNA, radionuclide, etc. Furthermore,bsMAb may redirect the cytotoxicity of immune effector cells toward the diseased cell or induce a systemic immune response against the target. This review focuses on therapeutic applications and production of bsMAb while providing the up-to-date clinical trial information.

Key words: bispecific monoclonal antibodies; preparation; methods

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