迷迭香酸的生物学功能及其在动物生产中的应用研究进展

doi:10.16431/j.cnki.1671-7236.2024.05.012

Abstract

Abstract: Rosmarinic acid is a natural phenolic acid compound widely found in many plants,which can be isolated from plants in the family of Comfrey,Cucurbitaceae,and Labiatae,etc.It possesses a variety of biological functions such as anti-inflammatory,antioxidant,bacteriostatic,anticancer,and antiviral,and it is widely used in the fields of food,medicine,and cosmetics.In veterinary clinics,rosmarinic acid and its source plants are widely used in the production of a variety of economic animals,such as pigs,poultry,ruminants,aquatic animals and rabbits,and have broad application prospects in regulating the intestinal microbial community,improving the immunity of the organism and production performance.In this paper,a systematic review of the biological functions of rosmarinic acid and its applications in the production of a variety of economic animals was conducted with the aim of providing references for the basic research on rosmarinic acid as well as its further application and promotion in animal production.

Key words: rosmarinic acid; biological function; animal production

CLC Number:

S816.7

PENG Ying, XIANG Yifei, YI Dandan, LIU Xia, WANG Menghui, ZHAO Linyi, HE Jiakang. Advances in Biological Functions of Rosmarinic Acid and Its Application in Animal Production[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(5): 1912-1920.

References

[1] KLOETZER L,BOMPA A S,BLAGA A C,et al.Study on rosmarinic acid separation by synergic extraction[J].Separation Science and Technology,2018,53(4):645-654.
[2] SCARPATI M L,ORIENTE G.Isolamento e costituzione dell'acido rosmarinico (dal rosmarinus off.)[J].Ric Sci,1958,28:2329-2333.
[3] JAYANTHY G,SUBRAMANIAN S.Extraction,isolation and characterization of rosmarinic acid,a major polyphenol in non-volatile constituent of mint leaves[J].Asian Journal of Research in Chemistry,2013,6(12):1160-1165.
[4] CALEJA C,BARROS L,PRIETO M A,et al.Extraction of rosmarinic acid from Melissa officinalis L.by heat-,microwave- and ultrasound-assisted extraction techniques:A comparative study through response surface analysis[J].Separation & Purification Technology,2017,186:297-308.
[5] MORAD C,EMILIE I,FABIEN L,et al.Optimization of the supercritical extraction of rosmarinic acid from clary sage residue and the antioxidant activity of the extracts[J].The Journal of Supercritical Fluids,2023,193:105830.
[6] LUO C X,ZOU L,SUN H J,et al.A Review of the anti-inflammatory effects of rosmarinic acid on inflammatory diseases[J].Frontiers in Pharmacology,2020,11:153.
[7] 任志清,李会珍,张志军,等.不同品种紫苏叶迷迭香酸的提取及其生物活性[J].现代食品科技,2021,37(1):92-100. REN Z Q,LI H Z,ZHANG Z J,et al.Extraction of rosmarinic acid from different varieties of Perilla leaves and its biological activity[J].Modern Food Science and Technology,2021,37(1):92-100.(in Chinese)
[8] 曹雯,张文娟,潘金凤,等.迷迭香酸药理作用的研究进展[J].广西中医药,2019,42(1):54-58. CAO W,ZHANG W J,PAN J F,et al.Research progress on the pharmacological effects of rosmarinic acid[J]. Guangxi University of Chinese Medicine,2019,42(1):54-58.(in Chinese)
[9] 曹礼慧,刘丽娟,袁中文,等.基于生物信息学预测迷迭香酸治疗子宫内膜癌的靶点和通路[J].宁夏医科大学学报,2022,44(12):1272-1278. CAO L H,LIU L J,YUAN Z W,et al.Predicting the target and pathway of rosmarinic acid in the treatment of endometrial carcinoma based on bioinformatics[J].Journal of Ningxia Medical University,2022,44(12):1272-1278.(in Chinese)
[10] 李珂,胡志敏.迷迭香酸生物学作用研究进展[J].国际检验医学杂志,2019,40(9):1032-1036. LI K,HU Z M.Advances in biological effects of rosmarinic acid[J].International Journal of Laboratory Medicine,2019,40(9):1032-1036.(in Chinese)
[11] MARCHEV A S,VASILEVA L V,AMIROVA K M,et al,et al.Rosmarinic acid-from bench to valuable applications in food industry[J].Trends in Food Science & Technology,2021,117:182-193.
[12] MANUELIAN C L,PITINO R,SIMONI M,et al.Plant feed additives as natural alternatives to the use of synthetic antioxidant vitamins on livestock mammals' performances,health,and oxidative status:A review of the literature in the last 20 years[J].Antioxidants,2021,10(9):1461.
[13] YAO Y,LIU Y,LI C,et al.Effects of rosemary extract supplementation in feed on growth performance,meat quality,serum biochemistry,antioxidant capacity,and immune function of meat ducks[J].Poultry Science,2023,102(2):102357.
[14] BINDU S,MAZUMDER S,BANDYOPADHYAY U.Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage:A current perspective[J].Biochemical Pharmacology,2020,180:114147.
[15] DHVANI S,PRAMILA C,VASANTI S.Role of natural products in alleviation of rheumatoid arthritis-A review[J].Journal of Food Biochemistry,2021,45(4):e13673.
[16] 吴佳庆,李润林,李盼盼,等.百里香酚和迷迭香酸对脂多糖攻毒大鼠盲肠屏障、菌群及炎症的影响[J].南京农业大学学报,2022,45(2):341-350. WU J Q,LI R L,LI P P,et al.Effects of combination of thymol and rosmarinic acid on barrier function,microbiota and inflammatory response in cecum of rats challenged with LPS[J].Journal of Nanjing Agricultural University,2022,45(2):341-350.(in Chinese)
[17] HO T Y,LO H Y,LIU I C,et al.Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition of the interleukin-17A/interleukin-17A receptor interaction[J].Food & Function,2022,13(12):6802-6812.
[18] LU Y H,HONG Y,ZHANG T Y,et al.Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride-induced liver damage[J].Food & Ntrition Research,2022,66:10.
[19] JIANG K F,MA X F,GUO S,et al.Anti-inflammatory effects of rosmarinic acid in lipopolysaccharide-induced mastitis in mice[J].Inflammation,2018,41:437-348.
[20] CHEN C P,LIN Y C,PENG Y H,et al.Rosmarinic acid attenuates the lipopolysaccharide-provoked inflammatory response of vascular smooth muscle cell via inhibition of MAPK/NF-κB cascade[J].Pharmaceuticals,2022,15(4):437.
[21] MA Z J,LU Y B,YANG F G,et al.Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways[J].Toxicology and Applied Pharmacology,2020,397:115014.
[22] KIM H K,HWANG S,SUNG B,et al.Gd-complex of a rosmarinic acid conjugate as an anti-inflammatory theranostic agent via reactive oxygen species scavenging[J].Antioxidants,2020,9(8):744.
[23] JIN J M,SEON L D,OK K S,et al.Protection of oxidative stress-induced DNA damage and apoptosis by rosmarinic acid in murine myoblast C2C12 cells[J].Biotechnology and Bioprocess Engineering,2022,27(2):171-182.
[24] 黄菁宇,曾亚琼,崔媚婷,等.迷迭香酸对卵巢储备功能减退小鼠卵巢的保护作用及机制[J].中华中药杂志,2022,37(7):3790-3795. HUANG J Y,ZENG Y Q,CUI M T,et al.Protective effect of rosmarinic acid on ovaries of mice with diminished ovarian reserve and its mechanism[J].China Journal of Traditional Chinese Medicine and Pharmacy,2022,37(7):3790-3795.(in Chinese)
[25] FATEMEH H,TAHEREH M K,ZEINAB H,et al.The protective effects of rosmarinic acid on ethanol-induced gastritis in male rats:Antioxidant defense enhancement[J].Research in Pharmaceutical Sciences,2021,16(3):305-314.
[26] KUMARA M S,RANI U S,ALI G.Anticancer potential of rosmarinic acid and its improved production through biotechnological interventions and functional genomics[J].Applied Microbiology and Biotechnology,2018,102(18):7775-7793.
[27] HOSSAN M S,RAHMAN S,BASHAR A,et al.Rosmarinic acid:A review of its anticancer action[J].World Journal of Pharmcy and Pharmaceutical Sciences,2014,3(9):57-70.
[28] 叶晨.TRPC1促进结直肠癌进展的研究及迷迭香酸靶向其抗癌作用的评价[D].西安:中国人民解放军空军军医大学,2021. YE C.A study on TRPC1 promoting the progression of colorectal cancer and the evaluation of anti-CRC effect of rosmarinic acid by targeting TR[D].Xi'an:Air Force Medical University,2021.(in Chinese)
[29] 覃秋莲,滕淑静,胡爽,等.迷迭香酸对宫颈癌PI3K/AKT/mTOR信号通路靶分子作用的研究[J].激光生物学报,2023,32(1):62-68. QIN Q L,TENG S J,HU S,et al.Effects of rosmarinic acid on target molecules of PI3K/AKT/mTOR signaling pathway in cervical cancer[J].Acta Laser Biology Sinica,2023,32(1):62-68.(in Chinese)
[30] TUMUR Z,GUERRA C,YANNI P,et al.Rosmarinic acid inhibits cell growth and migration in head and necks quamous cell carcinoma cell lines by attenuating epidermal growth factor receptor signaling[J].OMICS International,2015,12:7-12.
[31] JHENG J R,HSIEH C F,CHANG Y H,et al.Rosmarinic acid interferes with Influenza virus A entry and replication by decreasing GSK3β and phosphorylated AKT expression levels[J].Immunology and Infection,2022,55(4):598-610.
[32] RITESH P,SAIKAT G,RAJEEV M,et al.Antiviral activity of rosmarinic acid against four serotypes of Dengue virus[J]. Current Microbiology,2022,79(7):203.
[33] HSIEH C F,JHENG J R,LIN G H,et al.Rosmarinic acid exhibits broad anti-Enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors[J].Emerging Microbes & Infections,2020,9(1):1194-1205.
[34] 覃兰迁,刘霞,刘诚志,等.迷迭香水提物对沙门氏菌致小鼠肠道损伤的抗炎保护作用研究[J].饲料研究,2023,46(11):81-85. QIN L Q,LIU X,LIU C Z,et al.Study on anti-inflammatory and protective effect of Rosmarinus officinalis extract on intestinal injury induced by Salmonella in mice[J].Feed Research,2023,46(11):81-85.(in Chinese)
[35] EKAMBARAM S P,PERUMAL S S,BALAKRISHNAN A,et al.Antibacterial synergy between rosmarinic acid and antibiotics against methicillin-resistant Staphylococcus aureus[J].Journal of Intercultural Ethnopharmacology,2016,5(4):358-363.
[36] LIDYA H,ALEKSANDAR C,INGRID H,et al.Effect of rosmarinic acid on bull sperm quality and bacteria in semen[J].Animal Reproduction Science,2020,220:106395.
[37] ZHANG J H,CUI X,ZHANG M,et al.The antibacterial mechanism of perilla rosmarinic acid[J].Biotechnology and Applied Biochemistry,2021,69(4):1757-1764.
[38] MARIJA I,MARINA K,DEJAN S,et al.Rosmarinic acid-modes of antimicrobial and antibiofilm activities of common plant polyphenol[J].South African Journal of Botany,2022,146:521-527.
[39] 郭道森,杜桂彩,李丽,等.迷迭香酸对几种植物病原真菌的抗菌活性[J].微生物学通报,2004,31(4):71-76. GUO D S,DU G C,LI L,et al.Inhibitory activities of rosmarinic acid against plant pathogenic fungi[J].Microbiology China,2004,31(4):71-76.(in Chinese)
[40] 郭群群,杜桂彩,李荣贵,等.紫苏抗菌活性成分的研究[J].高等学校化学学报,2006,27(7):1292-1294. GOU Q Q,DU G C,LI R G,et al.Studies on antibacterial constituents of Perilla frutescens[J].Chemical Journal of Chinese Universities,2006,27(7):1292-1294.(in Chinese)
[41] 梁正敏,黄丽菊,朱宣霖,等.肿节风有效成分迷迭香酸对哮喘小鼠Th1/Th2型细胞因子水平的影响[J].黑龙江畜牧兽医,2017,15:201-203. LIANG Z M,HUANG L J,ZHU X L,et al.Effects of Zhongjiefeng effective components,rosmarinic acid,on the Th1/Th2 cytokine levels in asthmatic mice[J].Heilongjiang Animal Science and Veterinary Medicine,2017,15:201-203.(in Chinese)
[42] LIANG Z M,XU Y F,WEN X M,et al.Rosmarinic acid attenuates airway inflammation and hyperresponsiveness in a murine model of asthma[J]. Molecules,2016,21(6):769.
[43] 曹晓品,赵美霞,梁承磊.迷迭香酸基于AKT/mTOR通路促进抑郁模型大鼠海马神经元再生[J].海峡药学,2022,34(3):39-45. CAO X P,ZHAO M X,LIANG C L.Rosmarinic acid induces hippocampal neurogenesis on chronic depression rats through AKT/mTOR signaling pathway[J].Strait Pharmaceutical Journal,2022,34(3):39-45.(in Chinese)
[44] YU Y,LI Y,QI K M,et al.Rosmarinic acid relieves LPS-induced sickness and depressive-like behaviors in mice by activating the BDNF/Nrf2 signaling and autophagy pathway[J].Behavioural Brain Research,2022,433:114006.
[45] YU Y,WU Y,YAN H Z,et al.Rosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-α mediated antioxidant effect[J].Pharmaceutical Biology,2021,59(1):1284-1291.
[46] XIANG Y,JI M,WU L,et al.Rosmarinic acid prevents cisplatin-induced liver and kidney injury by inhibiting inflammatory responses and enhancing total antioxidant capacity,thereby activating the Nrf2 signaling pathway[J].Molecules,2022,27(22):7815.
[47] YANG M,YIN Y X,WANG F,et al.Effects of dietary rosemary extract supplementation on growth performance,nutrient digestibility,antioxidant capacity,intestinal morphology and microbiota of weaning pigs[J].Journal of Animal Science,2021,99(9):237.
[48] 雷铭康,李润林,李盼盼,等.饲粮添加迷迭香酸对产肠毒素大肠杆菌K88攻毒断奶仔猪结肠菌群组成、屏障功能及炎症反应的影响[J].动物营养学报,2022,34(8):4944-4958. LEI M K,LI R L,LI P P,et al.Effects of dietary rosmarinic acid on colonic microbiota composition,barrier function and inflammatory response in weaned piglets challenged with enterotoxigenic Escherichia coli K88[J].Chinese Journal of Animal Nutrition,2022,34(8):4944-4958.(in Chinese)
[49] 赵文轩,吴建民,党苗苗,等.橙皮苷与迷迭香酸组合对育肥猪盲肠肠道形态、抗氧化功能、菌群结构及屏障功能的影响[J].微生物学报,2023,63(11):4356-4371. ZHAO W X,WU J M,DANG M M,et al.Combination of hesperidin and rosmarinic acid affects cecal morphology,antioxidant function,microbiota structure,and barrier function of finishing pigs[J].Acta Microbiologica Sinica,2023,63(11):4356-4371.(in Chinese)
[50] ZHANG Q J,GONG J T,XIANG H K,et al.Effects of main active components of rosemary on growth performance,meat quality and lipid metabolism in finishing pigs[J].Animal Nutrition,2023,15:341-349.
[51] 台瑞青.迷迭香酸对育肥猪抗氧化水平与脂肪代谢的影响[D].杨凌:西北农林科技大学,2022. TAI R Q.Effects of rosmarinic acid on antioxidant level and fat metabolism in finishing pigs[D].Yangling:Northwest A&F University,2022.(in Chinese)
[52] 陈露,赵道远,吴建民,等.橙皮苷和迷迭香酸对白羽肉鸡生长性能、肉品质及抗氧化功能的影响[J].南京农业大学学报,2023,46(4):756-763. CHEN L,ZHAO D Y,WU J M,et al.Combination effects of hesperidin and rosmarinic acid on growth performance,meat quality and antioxidant function in broilers[J].Journal of Nanjing Agricultural University,2023,46(4):756-763.(in Chinese)
[53] 陈露,吴建民,尹莉丽,等.橙皮苷和迷迭香酸对白羽肉鸡免疫器官指数、血清生化指标及盲肠菌群的影响[J].中国家禽,2022,44(11):37-43. CHEN L,WU J M,YIN L L,et al.Effects of hesperidin and rosmarinic acid on immune organ index,serum biochemical indexes and cecal microflora of White-feathered broilers[J].China Poutry,2022,44(11):37-43.(in Chinese)
[54] SHANG R S,CHEN L F,XIN Y Z,et al.Evaluation of rosmarinic acid on broiler growth performance,serum biochemistry,liver antioxidant activity,and muscle tissue composition[J].Animals,2022,12(23):3313.
[55] 酉加民,杨茜梓,宫嘉泰,等.迷迭香酸对堆型艾美耳球虫攻毒肉鸡生长性能、免疫机能及炎症反应的影响[J].动物营养学报,2023,35(9):5696-5707. YOU J M,YANG X Z,GONG J T,et al.Effects of rosmarinic acid on growth performance,immune function and inflammatory response of broilers challenged with Eimeria acervulina[J].Chinese Journal of Animal Nutrition,2023,35(9):5696-5707.(in Chinese)
[56] CAI X,ZHANG L,CHEN X J,et al.Orthosiphon stamineus and rosmarinic acid reduce heat stress in laying hens[J].Livestock Science,2020,240:104124.
[57] STEFA AN'G SKA B,KATZER F,GOLINSKA B,et al.Different methods of eubiotic feed additive provision affect the health,performance,fermentation,and metabolic status of dairy calves during the preweaning period[J].BMC Veterinary Research,2022,18(1):138.
[58] STEFA AN'G SKA B,SROKA J,KATZER F,et al.The effect of probiotics,phytobiotics and their combination as feed additives in the diet of dairy calves on performance,rumen fermentation and blood metabolites during the preweaning period[J].Animal Feed Science and Technology,2020,272:114738.
[59] KONG F L,WANG S,DAI D W,et al.Preliminary investigation of the effects of rosemary extract supplementation on milk production and rumen fermentation in high-producing dairy cows[J].Antioxidants,2022,11(9):1715.
[60] KHOLIF A E,MATLOUP O H,MORSY T A,et al.Rosemary and lemongrass herbs as phytogenic feed additives to improve efficient feed utilization,manipulate rumen fermentation and elevate milk production of Damascus goats[J]. Livestock Science,2017,204:39-46.
[61] 张紫阳.迷迭香提取物对奶山羊产奶性能和血液指标的影响[D].长沙:湖南农业大学,2021. ZHANG Z Y.Effects of rosemary extract on milk performance and blood indices of dairy goats[D].Changsha:Hunan Agricultural University,2021.(in Chinese)
[62] SAEED H,HOSSEIN K M.Rosmarinic acid alone or in combination with Lactobacillus rhamnosus ameliorated resistance to ammonia stress in the rainbow trout,oncorhynchus mykiss:Growth,immunity,antioxidant defense and liver functions[J].Annals of Animal Science,2023,23(3):819-831.
[63] 刘策,张印,刘公言,等.饲粮中迷迭香提取物添加水平对肉兔生长性能、屠宰性能、肌肉品质和抗氧化性能的影响[J].动物营养学报,2023,35(1):536-545. LIU C,ZHANG Y,LIU G Y,et al.Effects of detary rosemary extract supplemental level on growth performance,slaughter performance,muscle quality and antioxidant capacity of meat rabbits[J].Chinese Journal of Animal Nutrition,2023,35(1):536-545.(in Chinese)
[64] 王贤泽,李光全,王惠影,等.日粮添加迷迭香提取物对浙东白鹅生长性能、血清生化、抗氧化和免疫指标的影响[J].中国家禽,2022,44(6):62-67. WANG X Z,LI G Q,WANG H Y,et al.Effects of dietary supplement of rosemary extract on growth performance,serum biochemical,antioxidant and immune indexes of Zhedong White goose[J].China Poultry,2022,44(6):62-67.(in Chinese)
[65] YAO Y Z,LIU Y,LI C,et al.Effects of rosemary extract supplementation in feed on growth performance,meat quality,serum biochemistry,antioxidant capacity,and immune function of meat ducks[J]. Poultry Science,2023,102(2):102357.

Advances in Biological Functions of Rosmarinic Acid and Its Application in Animal Production

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