胰高血糖素样肽-2及其在畜牧生产中的应用

doi:10.16431/j.cnki.1671-7236.2019.06.006

Abstract

Abstract:

Glucagon-like peptide-2(GLP-2) is a short peptide consisting of 33 amino acid residues and mainly secreted by L endocrine cells located in the small intestine edge and colon.GLP-2 can binds to its receptor GLP-2R to activate a series of downstream reactions to achieve its functions.It can promote intestinal growth and development,repair of damaged intestine,accelerate nutrient transport and absorption,and enhance intestinal mucosal barrier function.At present,GLP-2 and[Gly-2] GLP-2 have been approved for the treatment of human intestinal mucosal injury diseases such as short bowel syndrome.In addition,GLP-2 has a wide range of applications in livestock production because of its many functions.For example,GLP-2 can be used in the treatment of some common gastrointestinal inflammatory diseases in livestock.It can also alleviate lung injury caused by bovine sepsis and play an important role in maintaining liver health.Besides,as an anorexia signal peptide,GLP-2 can increases the conversion rate of food in livestock.GLP-2 is also used to relieve adverse environmental stress caused by changes in the surrounding environment,such as heat stress,water deficiency stress,fluorosis and intestinal dysfunction during diet switching and so on,In this paper,the latest research progress of GLP-2 and its application in animal production are discussed.

Key words: GLP-2; research progress; application; animal production

CLC Number:

Q514⁺.3

HAN Fei, JIANG Mingfeng, WANG Gang. Glucagon-like Peptide-2 and Its Application in Animal Production[J]. , 2019, 46(6): 1612-1618.

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Glucagon-like Peptide-2 and Its Application in Animal Production

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