禽类产品及饲料中尼卡巴嗪药物检测分析方法研究进展

doi:10.16431/j.cnki.1671-7236.2021.12.041

Abstract

Abstract: Nicarbazin (NIC) is a class of compounds composed of 4 4’-dinitrocarbanilide (DNC) and 2-hydroxyl-4, 6-dimethylpyrimidine (HDP), in which DNC is its residual marker.NIC is widely used in coccidiosis control of chickens and turkeys due to its safety and high efficiency.In recent years, its residue problem was high, which seriously threatened the safety of animal derived food and the safety of consumers’ life and health.At present, the analysis methods for NIC in poultry products and feed mainly include instrumental analysis methods and immunoassay methods.Among them, instrumental analysis methods, as confirmatory methods, have the advantages of high specificity, high sensitivity and reliable results, mainly including high performance liquid chromatography (HPLC) and liquid chromatography tandem mass spectrometry (LC-MS/MS).Immunoassay is the mainstream technology for rapid detection of NIC, which has the advantages of high inspection speed, low cost and strong practicability.It mainly includes enzyme-linked immunosorbent assay (ELISA), immunochromatography (IC), surface plasmon resonance (SPR), fluorescent immunoassay (FIA) and flow cytometry (FCM) etc.This paper summarized the detection and analysis methods of NIC in poultry products and feed at home and abroad in recent 40 years, so as to provide theoretical and practical guidance for NIC residue monitoring.

Key words: nicarbazine; detection and analysis; poultry products; feed; instrumental analysis methods; immunoassays

CLC Number:

S859

YIN Yongkang, WANG Xiaoliang, CUI Yanli, LIANG Xiao. Research Progress on the Detection and Analysis Methods of Nicarbazine in Poultry Products and Feed[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(12): 4725-4734.

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Research Progress on the Detection and Analysis Methods of Nicarbazine in Poultry Products and Feed

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