Abstract: Toxoplasmosis is a worldwide important zoonotic parasitic disease,which infects almost all warm-blooded animals,including human beings.At present,controlling this disease mainly depends on drugs.Clinically,sulfadiazine and pyrimethamine are used to treat the disease,which is seemed as the gold standard.However,this therapy has certain toxic and side effects,and is prone to drug resistance after long-term use.So development of anti-toxoplasmosis drug has always been a hotspot.Spiramycin,trimethoprim-sulfamethoxazole and so on are used as alternatives in treating toxoplasmosis,however,they all have different limitations.Therefore,the focus of research has been shifted to natural products.Plant extracts were used as the main component.Through screening the active molecules with anti-Toxoplasma gondii and modifying them properly,the anti-Toxoplasma gondii activity can be enhanced and the side effects can be reduced.Among animal extracts,the venom of some animals has anti-Toxoplasma gondii activity and can be good candidate drugs. With the progress of research methods,the new activities of some existing drugs have been continuously discovered.In the research direction of the new use of ‘old’ drugs,on the one hand,according to genetic relationship,the anti-Toxoplasma gondii activity of other anti-parasite drugs can be explored.On the other hand,depending on the drug action target,the anti-Toxoplasma gondii activity of drugs for the treatment of other diseases is being studied.To sum up,this article reviewed the clinical drug history of toxoplasmosis,the development of natural products and the new use of ‘old’ drugs,which provided new ideas for the development of anti-toxoplasmosis drugs.

Key words: Toxoplasma gondii; anti-Toxoplasma drugs; natural product; reuse of drugs