代谢组学技术在有毒有害物质检测应用中的研究进展

doi:10.16431/j.cnki.1671-7236.2019.06.036

Abstract

Abstract:

Some toxic and harmful substances can lead to huge risks of food safety such as pathogenic microorganisms,biotoxins,pesticides,veterinary drugs and additives residues.Nowadays,monitoring of toxic and hazardous substances still faces enormous challenges.Metabolomics techniques detect metabolically changes in organisms which are stimulated or interfered by toxic and hazardous substances,then it will perform qualitative and quantitative analysis of the data and obtain highly sensitive and specific metabolomics projection,which makes it suitable for simultaneous monitoring of different trace toxicants.Metabolomics technology can reflect possible biomarkers in the process of toxicant metabolism,and provide references for further researches on toxic metabolic processes and toxicological mechanisms.Therefore,the metabolomics method represented by chromatographic mass spectrometry,nuclear magnetic resonance and other methods has gradually become a key technology for the detection of toxic and hazardous substances,and it provides a basis for risk assessment of toxic and hazardous substances.The discovery of various biomarkers and the optimization of detection methods will promote the practical application of metabolomics technology in simultaneous monitoring of toxicant.The generation and development of metabolomics technology were introduced,and the researches of metabonomics methods and biomarkers of metabolites were summarized in this paper in order to provide references for the further application of metabolomics technology in the detection of toxic and harmful substances.

Key words: metabolomics; toxic and harmful substances; biomarkers; residue

CLC Number:

R284

OU Yahong, WANG Yuke, ZHANG Liyun, WANG Yanxin, PENG Dapeng, XIE Shuyu, HUANG Lingli, PAN Yuanhu, CHEN Dongmei, WANG Xu, WANG Yulian, TAO Yanfei. Research Progress on Metabonomics in the Detection of Toxic and Harmful Substances[J]. , 2019, 46(6): 1865-1872.

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Research Progress on Metabonomics in the Detection of Toxic and Harmful Substances

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