牛病毒性腹泻病毒致病机制研究进展

doi:10.16431/j.cnki.1671-7236.2018.08.032

Abstract

Abstract:

Bovine viral diarrhea (BVD) and mucosal disease (MD) are all infectious diseases caused by the infection of bovine viral diarrhea virus (BVDV).The diseases threaten the development of the cattle industry seriously.This article briefly summarized the genotyping and molecular biological features of BVDV.BVDV can be divided into two genotypes and two biotypes according to sequence conservation and cytopathic effect.The newly discovered ‘HoBi’ strain is classified as Pestivirus genus,and the BVDV gene has evolved rapidly.The genome encodes four structural proteins and eight non-structural proteins.Coding proteins play an important role in the virus replication,translation and the host pathogenic process.The pathogenesis of BVDV is complicated.In this review,we summed up BVDV current researches on pathogenesis,including acute infection,uterine or placenta infection,persistent infection and mucosal disease,which was useful for discovery of new methods of control propagation.Acute infections can cause viremia,reproductive disorders,immunosuppression,and so on.The causes of diarrhea in acutely infected cattle are associated with the infection of the gastrointestinal muscularis,submucosa and normal function of the intestinal nerves by BVDV,and non-cytopathic (NCP) BVDV is the cause of acute infection.The mechanism of BVDV infection in embryos is more complicated,which depends on the fetal growth stage in the uterus during the first invasion of BVDV.NCP BVDV has the ability to inhibit the production of type Ⅰ interferon in the fetus causing the virus to survive in the host and forming a persistent infected cow.Mucosal disease is directly induced when the persistently infected cow re-infects a cytopathic (CP) strain that is highly homologous to NCP BVDV.Both biotypes are important factors in the development of persistent infection and mucosal disease.NCP BVDV can be transformed into CP BVDV.These fundamental researches are important for eliminating of BVD-MD and providing a basis for the development of new vaccines.

Key words: bovine viral diarrhea virus (BVDV); acute infection; uterine or placenta infection; persistent infection; mucosal disease

CLC Number:

S858.23

LI Xinpei, ZHOU Weiguang, GUAN Pingyuan, CHENG Shipeng, WEN Yongjun. Research Progress on Pathogenesis of Bovine Viral Diarrhoea Virus[J]. , 2018, 45(8): 2303-2311.

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Research Progress on Pathogenesis of Bovine Viral Diarrhoea Virus

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