牛病毒性腹泻病毒的分子生物学研究进展

doi:10.16431/j.cnki.1671-7236.2017.11.004

Abstract

Abstract:

Bovine viral diarrhea virus (BVDV) is one of the most important pathogenic viruses which mainly causes bovine viral diarrhea disease (BVD). BVDV can not only cause serious clinical symptoms, but also lead to decrease of immunity of livestock and infect other pathogens, resulting in significant increase of morbidity and mortality of sick animals, and causes significant losses to the cattle industry. With the development of molecular biology theory and technology in recent years, the research on BVDV has been deepening, and some new understandings have been made to the molecular biology of the virus. In this paper, the progress of molecular biology of BVDV in recent years is described from three aspects of the composition and function of virus, the epidemic situation of BVDV gene and the genetic and mutation of BVDV gene.

Key words: bovine viral diarrhea virus (BVDV); etiology; epidemiology; hereditary variation

CLC Number:

S858.23

CHEN Xin-nuo, ZHANG Bin. Research Progress on Molecular Biology of Bovine Viral Diarrhea Virus[J]. , 2017, 44(11): 3137-3142.

References

[1] Bachofen A, Vogt H R, Stalder H, et al. Persistent infections after natural transmission of bovine viral diarrhoe virus from cattle to goats and among goats[J].Vet Res, 2013, 44(1):32.
[2] 包振中, 雷程红, 蔡元庆, 等. 牛病毒性腹泻-黏膜病病毒分离鉴定及生物学特性研究[J]. 中国畜牧兽医, 2015, 42(9):2391-2398.
[3] 李文文, 刘情, 刘亚刚. 牛病毒性腹泻病毒间接ELISA方法的建立[J]. 中国畜牧兽医, 2015, 42(3):558-562.
[4] Ridpath J F. BVDV genotypes and biotypes:Practical implications for diagnosis and control[J]. Biols, 2003, 31(2):127-131.
[5] Deng M, Ji S, Fei W, et al. Prevalence study and genetic typing of bovine viral diarrhea virus (BVDV) in four bovine species in China[J]. PLoS One, 2015, 10(4):e0121718.
[6] Zemke J. Characterization of recombinant BVDV-2 vaccine prototypes based on packaged replicons and replication competent deletion mutants[D]. LMU Munchen:Tierarztliche Fakultat, 2010.
[7] Ridpath J F. Practical significance of heterogeneity among BVDV strains:Impact of biotype and genotype on U.S. control programs[J]. Prev Vet Med, 2005, 72:17-30.
[8] 王银. 表达牛病毒性腹泻病毒E2基因的重组Ⅰ型牛疱疹病毒的构建[D]. 扬州:扬州大学,2013.
[9] 梁霄勇, 季新成, 冉多良. 牛病毒性腹泻病毒TC株的分离鉴定及E0基因的序列分析[J]. 畜牧与兽医, 2016, 48(7):36-40.
[10] Liang D, Sainz I F, Ansari I H, et al. The envelope glycoprotein E2 is a determinant of cell culture tropism in ruminant pestiviruses[J].J Gen Virol, 2003, 84(Pt 5):1269-1274.
[11] Gil L H, Ansari I H, Vassilev V, et al. The amino-terminal domain of bovine viral diarrhea virus Npro protein is necessary for alpha/beta interferon antagonism[J]. J Virol, 2006, 80(2):900-911.
[12] Tao J, Liao J, Wang J, et al. Pig BVDV-2 non-structural protein (Npro) links to cellular antiviral response in vitro[J]. Viruses, 2015, 53(2):233-239.
[13] Kalaiyarasu S, Mishra N, Rajukumar K, et al. Development and evaluation of a truncated recombinant NS3 antigen-based indirect ELISA for detection of pestivirus antibodies in sheep and goats[J]. J Immunoassay Immunochem, 2015, 36(3):312-323.
[14] Ridpath J F, Bendfeldt S, Neill J D, et al. Lymphocytopathogenic activity in vitro correlates with high virulence in vivo for BVDV type 2 strains:Criteria for a third biotype of BVDV[J]. Virus Res,2006,118(1-2):62-69.
[15] 毛晓娜, 繆芬芳, 季伟. 牛病毒性腹泻病毒在猪瘟疫苗中的污染情况及其检测方法的研究进展[J]. 中国畜牧兽医, 2013, 40(2):175-178.
[16] 李庆超, 苗利光, 李海涛. 中国牛病毒性腹泻病毒JZ05-1分离株全基因测序及分析[J]. 病毒学报, 2010,26(3):238-243.
[17] 何美琳, 张焕容, 王永, 等. 川西北牦牛3种病毒性腹泻病血清学调查[J]. 中国畜牧兽医, 2014, 41(3):248-250.
[18] 王晓亮, 王玉梅, 张玉玲, 等. 宁夏部分地区牛病毒性腹泻的血清学检测[J]. 中国动物检疫, 2016, 33(2):17-19.
[19] 王淑娟, 王华, 宋晓晖, 等. 牛病毒性腹泻/黏膜病的诊断流行病学调查及防控[J]. 中国兽医杂志, 2014, 50(3):38-40.
[20] 李智勇, 石顺利, 王艳杰, 等. 内蒙古地区奶牛病毒性腹泻/黏膜病血清流行病学调查[J]. 畜牧与饲料科学, 2014(3):106-108.
[21] 姚伟. 辽宁地区规模化奶牛场牛病毒性腹泻-黏膜病血清学调查[J]. 现代畜牧兽医, 2015,4:36-40.
[22] 陈新诺, 张朝辉, 徐林. 青藏高原牦牛感染BVDV和BEV的分子流行病学调查[J]. 动物医学进展, 2016, 37(9):39-42.
[23] Nilnont T, Aiumlamai S, Kanistanont K, et al. Bovine viral diarrhea virus (BVDV) infection in dairy cattle herds in Northeast Thailand[J]. Trop Anim Health Prod, 2016, 48(6):1201-1208.
[24] Yilmaz V. Prevalence of antibodies to bovine viral diarrhea virus (BVDV) in blood and milk serum in dairy cattle in Kars district of Turkey[J]. Indian J Anim Res, 2016, 50(5):811-815.
[25] Sausker E A, Dyer N W. Seroprevalence of OHV-2, BVDV, BHV-1 and BRSV in ranch-raised bison (Bison bison)[J]. J Vet Diagn Invest, 2002, 14(1):68-70.
[26] Mahmoud M, Allam A. Seroprevalence of bovine viral diarrhea virus (BVDV), bovine herpes virus type 1(BHV-1), parainfluenza type 3 virus (PI-3V) and bovine respiratory syncytial virus (BRSV) among non-vaccinated cattle[J]. Glo Vet, 2013, 10(3):348-353.
[27] Guarino H. Prevalence of serum antibodies to bovine herpesvirus-1 and bovine viral diarrhea virus in beef cattle in Uruguay[J]. Prev Vet Med, 2008, 85(1-2):34-40.
[28] Giammarioli M, Ceglie L, Rossi E, et al. Increased genetic diversity of BVDV-1:Recent findings and implications thereof[J]. Virus Genes, 2015, 50(1):147-151.
[29] Schirrmeier H, Strebelow G, Depner K, et al. Genetic and antigenic characterization of an atypical pestivirus isolate, a putative member of a novel pestivirus species[J]. J Gen Virol, 2004, 85(Pt 12):3647-3652.
[30] Russell G C,Grant D M,Lycett S,et al.Analysis of bovine viral diarrhoea virus:Biobank and sequnce database to support eradication in Scatland[J].Vet Rec,2017,180(18):447.
[31] Tajima M, Frey H R, Yamato O, et al. Prevalence of genotypes 1 and 2 of bovine viral diarrhea virus in Lower Saxony, Germany[J]. Virus Res, 2001,76(1):31-42.
[32] 汤中和. 牛病毒性腹泻病的JN株的分离鉴定及E2基因的序列分析[J]. 中国畜牧兽医, 2013, 40(5):83-86.
[33] Pecoraa A, Malacaria D A, Perez M S. Development of an APC-targeted multivalent E2-based vaccine against bovine viral diarrhea virus types 1 and 2[J]. Vaccine, 2015, 33(39):5163-5171.
[34] Ostachuk A. Bovine viral diarrhea virus structural protein E2 as a complement regulatory protein[J]. Arch Virol, 2016, 161(7):1769-1782.
[35] Ridpath J F, Lovell G, Neill J D, et al. Change in predominance of bovine viral diarrhea virus subgenotypes among samples submitted to a diagnostic laboratory over a 20-year time span[J]. J Vet Diagn Invest, 2011, 23(2):185-193.
[36] Toplak I, Sandvik T, Barlic^-Maganja D, et al. Genetic typing of bovine viral diarrhoea virus:Most slovenian isolates are of genotypes 1d and 1f[J]. Vet Microbiol, 2004, 99(3-4):175-185.
[37] Abe Y, Tamurar T, Torii S, et al. Genetic and antigenic characterization of bovine viral diarrhea viruses isolated from cattle in Hokkaido, Japan[J]. J Vet Med Sci, 2016, 78(1):61-70.
[38] Oem J K, Chung J Y, Rohi S, et al. Characterization and phylogenetic analysis of bovine viral diarrhea virus in brain tissues from nonambulatory (downer) cattle in Korea[J]. J Vet Diagn Invest, 2010, 22(4):518-523.
[39] Lanyon S, Reichel M. Bovine viral diarrhoea virus ("pestivirus") in Australia:To control or not to control[J]. Australian Vet J, 2014, 92(8):277-282.
[40] Liu L, Xia H, Wahlberg N, et al. Phylogeny,classification and evolutionary insights into pestiviruses[J]. Virology, 2009, 385(2):351-357.
[41] Gong X, Liu L, Zheng F, et al. Molecular investigation of bovine viral diarrhea virus infection in yaks (Bos gruniens) from Qinghai, China[J]. Virol J, 2014, 11:29.
[42] 陈锐, 范学政, 朱元源. 西部散养肉牛病毒性腹泻病毒流行与遗传变异[J]. 中国农业科学, 2016, 49(13):2634-2641.
[43] 王炜. 牛主要呼吸道病毒血清学调查、牛病毒性腹泻病毒分离株鉴定及疫苗研究[D]. 北京:中国农业科学院, 2014.

Research Progress on Molecular Biology of Bovine Viral Diarrhea Virus

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	KANG Pu, REN Zhaowen, CAI Rujian, LYU Zongji, HUANG Yuhao, WANG Xiaohu. Variation Regularity and Transmission of PRRSV-2 Lineage 8 Strains in Guangdong and Surrounding Provinces [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2001-2011.
[2]	LIU Kexin, WANG Chao, ZHANG Ao, LIU Jiali, TAN Bin, ZHANG Shuqin. Isolation,Identification and Genome Sequence Analysis of Bovine Viral Diarrhea Virus LN-1 Strain [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1150-1159.
[3]	SHAO Baihui, JIANG Dongjun, XIE Yimeng, LIU Siyu, SHAO Ziyi, ZHANG Zecai, JI Hong, ZHU Zhanbo. Molecular Docking Prediction of Artemisinin and NS5B Protein of Bovine Viral Diarrhea Virus and Its Antiviral Effect [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3581-3588.
[4]	WANG Wei, HAN Huihui, DING Naizheng, HE Chengqiang. Prokaryotic Expression of Bovine Viral Diarrhea Virus E0 Protein and Preparation of Polyclonal Antibody [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 3131-3139.
[5]	LIANG Yingxin, CHEN Zejia, LI Jichao, CUI Xiaoxiao, FENG Qianqi, LI Shoujun, CHEN Aolei. Investigation on the Infection of Equine Intestinal Parasite in Partial Cities in Guangdong Province [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2725-2734.
[6]	REN Jie, LIN Ling, TANG Deyuan, ZENG Zhiyong, WANG Bin, YU Guangmei, ZHENG Ruwen, WU Daoyi, HUANG Tao. Construction of Bovine Viral Diarrhea Virus E0-E2 Gene Fusion Adenovirus and Evaluation of Immune Effect in Mice [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2056-2063.
[7]	MA Baoyi, SHENG Chenyan, LIU Hongying, MA Qingxia, WANG Tingting, LI Jianming, SHI Kun, DU Rui, LENG Xue. Establishment of a Duplex TaqMan Real-time PCR Method for Detection of Bovine Viral Diarrhea Virus Types 1 and 2 [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2326-2335.
[8]	GUO Luanying, LI Jialei, JIN Qinqin, MA Jun, LIU Quan. Research Progress on Bovine Hepacivirus [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1994-2000.
[9]	WU Tongzhong, NUERSAILIKE Nusufu, HUANG Xin, HAN Mengli, ZHANG Xingxing, ZHANG Qian, WANG Xinhua, HE Yanhua, ZHONG Fagang. Construction of Recombinant Lactococcus Expressing E2 Protein of Bovine Viral Diarrhea Virus and Immunogenicity Analysis of the Protein [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(8): 2975-2981.
[10]	YIN Yanwen, SHI Kaichuang, SUN Wenchao, XIE Shouyu, QU Sujie, LU Wenjun, WANG Luxia, QIN Yong, PEI Xingbiao, LING Dan. Surveillance Analysis of Low Pathogenic Avian Influenza Virus in Border Areas of Guangxi from 2013 to 2019 [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(8): 3002-3009.
[11]	FU Qiang, HE Yuanxiu, LI Zeyu, JIEENSI Sailike, ZHOU Yuxin, YANG Li, RAN Duoliang, SHI Huijun. Effects of Small Molecular Drug Sofosbuvir on Bovine Viral Diarrhea Virus Replication in vitro [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(7): 2653-2660.
[12]	ZHANG Shuang, GUO Yu, XUE Wenhui, ZHAO Qianhui, HUO Shuying. Research Progress on Poultry Candida glabrata [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(3): 1013-1019.
[13]	CHANG Liyun, LIU Zhiyong, QIN Jianhua, ZHAO Yuelan. Epidemiological Investigation of Viral Diarrhea of Dairy Calves in Tangshan City, Hebei Province [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(11): 4213-4219.
[14]	SUN Jiali, DONG Hao, PENG Xiaowei, ZHU Liangquan, JIANG Hui, FENG Yu, LI Xiaoying, DING Jiabo, WANG Chunfeng. Research Progress on Brucella canis [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(10): 3803-3811.
[15]	YANG Yan, QIAN Tianhao, ZHANG Yanhong, ZHANG Zhe, HAO Xiujing, LI Yan, LYU Wenhua, LIU Zhao, SHENG Jinliang. Screening and Reactogenicity Test of Bovine Viral Diarrhea Virus NS3 Protein Nanobody [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(1): 303-311.