黄牛呼吸道CD3+淋巴细胞分布的研究

doi:10.16431/j.cnki.1671-7236.2018.05.033

Abstract

Abstract:

CD3⁺ is an important surface marker of T cell population.CD3⁺ lymphocytes which are distributed under respiratory tract mucosae as the basis of anti-infective mucosal immunity play an important role in protecting the body against respiratory infection.In order to understand the distribution profile of CD3⁺ lymphocytes and lymphoid tissues in cattle respiratory tract for the mucosal immune strategy of respiratory tract,the samples of nasal mucosa,trachea,pulmonary bronchia and lung from five 7-month-old health cattle were collected and the distribution of CD3⁺ lymphocytes and lymphoid tissues was tested by HE staining and immunohistochemistry methods.The results showed that CD3⁺ lymphocytes distributed in mucosal epithelium,below lamina propria and around gland in nose,trachea and pulmonary bronchia and lung.CD3⁺ lymphocytes form diffuse lymphoid tissue in nasal mucosa and lung.The number of the CD3⁺ lymphocytes were the largest in nasal mucosa and lung,followed by trachea and pulmonary bronchia.The results made clear the distribution profile of CD3⁺ lymphocytes in cattle respiratory tract.It indicated that the respiratory tract of cattle had the basic conditions for initiating local mucosal immunity.This study would provide the basic data for mucosal immunity in respiratory tract and prevention and treatment for respiratory disease in cattle.

Key words: cattle; CD3⁺ lymphocytes; lymphoid tissue; respiratory tract tissues

CLC Number:

S852.31

LI Yijiang, BENG Dexin, GUO Zhaoting, YU Shaorong, DING Hong, YAN Xinquan, ZHANG Shuguang, YANG Ke, GUO Zhaowei, LUO Xiangbo, LI Jiayun, YANG Qian. Study on Distribution of CD3⁺ Lymphocytes in Cattle Respiratory Tract[J]. , 2018, 45(5): 1389-1394.

References

[1] DAR A A,BHAT S A,GOGOI D,et al.Inhibition of notch signalling has ability to alter the proximal and distal TCR signalling events in human CD3⁺αβ T-cells[J].Molecular Immunology,2017,92:116-124.
[2] WANG X,GONG Z,LI S X,et al.Extranodal nasal-type natural killer/T-cell lymphoma with penile involvement:A case report and review of the literature[J].BMC Urology,2017,17(1):77.
[3] CLIFFORD T,WOOD M J,STOCKS P,et al.T-regulatory cells exhibit a biphasic response to prolonged endurance exercise in humans[J].European Journal of Applied Physiology,2017,117(8):1727-1737.
[4] FURLANETTO G,ALEGRETTI A P,FARIAS M G,et al.Cut-off value for absolute lymphocytes as an alternative for the immunophenotypic analysis of CD3⁺ T cells in the monitoring of immunosuppressive therapy with thymoglobulin[J].Journal Brasileiro de Nefrologia,2017,39(2):181-185.
[5] FUKAHORI H,CHIDA N,MAEDA M,et al.Effect of AS2521780,a novel PKC selective inhibitor,on T cell-mediated immunity[J].European Journal of Pharmacology,2014,745:217-222.
[6] JIN C,DUAN X,LIU Y,et al.T cell immunity induced by a bivalent Salmonella-based CEACAM6 and 4-1BBL vaccines in a rat colorectal cancer model[J].Oncology Letters,2017,13(5):3753-3759.
[7] 杨倩.黏膜免疫及其疫苗设计[M].北京:科学出版社,2016. YANG Q.Mucosal Immunization and Vaccine Strategies[M].Beijing:Science Press,2016.(in Chinese)
[8] ZHANG A,XU J,LAI H,et al.Age-related changes and distribution of T cell markers (CD3 and CD4) and Toll-like receptors(TLR2,TLR3,TLR4 and TLR7) in the duck lymphoid organs[J].Immunobiology, 2017,222(7):857-864.
[9] YANG J J,DAI L,YU Q H,et al.Histological and anatomical structure of the nasal cavity of Bama minipigs[J].PLoS One,2017,2(3):e0173902.
[10] LOH L,WANG Z,SANT S,et al.Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation[J].Proceedings of the National Academy of Sciences of the United States of America,2016,113(36):10133-10138.
[11] GUO C,SHEN X,FU B,et al.CD3(bright) CD56⁽⁺⁾ T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients[J].Scientific Reports,2016,6:25567.
[12] WOODLAND D L,RANDALL T D.Anatomical features of anti-viral immunity in the respiratory tract[J].Seminars in Immunology,2014,16(3):163-170.
[13] STENFELDT C,DIAZ-SAN SEGUNDO F,DE LOS SANTOS T,et al.The pathogenesis of foot-and-mouth disease in pigs[J]. Journal of Veterinary Science,2016,3:41.
[14] MCGILL J L,SACCO R E.T cells and the immune response to respiratory syncytial virus infection[J].Veterinary Immunology and Immunopathology,2016,181:24-29.
[15] MEYER SAUTEUR P M,DE GROOT R C A,ESTEV O S C,et al.The role of B cells in carriage and clearance of Mycoplasma pneumoniae from the respiratory tract of mice[J].Journal of Infectious Diseases,2017,217(2):298-309.
[16] HANOT MAMBRES D, MACHELART A,POTEMBERG G,et al.Identification of immune effectors essential to the control of primary and secondary intranasal infection with Brucella melitensis in mice[J].Journal of Immunology,2016,196(9):3780-3793.
[17] KYD J M,FOXWELL A R,CRIPPS A W.Mucosal immunity in the lung and upper respiratory[J].Vaccine,2001,19(17-19):2527-2533.
[18] GARG R,LATIMER L,GERDTS V,et al.Intranasal immunization with a single dose of the fusion protein formulated with a combination adjuvant induces long-term protective immunity against respiratory syncytial virus[J].Human Vaccines & Immunotherapeutics,2017,21:1-8.
[19] XIE Y,GAO P,LI Z.Recombinant adenovirus expressing P12A and 3C protein of the type O foot-and-mouth disease virus stimulates systemic and mucosal immune responses in mice[J].Biomed Research International,2016,2016:7849203.
[20] GARG R,THEAKER M,MARTINEZ E C,et al.A single intranasal immunization with a subunit vaccine formulation induces higher mucosal IgA production than live respiratory syncytial virus[J].Virology, 2016,499:288-297.
[21] PAWAR D,MANGAL S,GOSWAMI R,et al.Development and characterization of surface modified PLGA nanoparticles for nasal vaccine delivery:Effect of mucoadhesive coating on antigen uptake and immune adjuvant activity[J].European Journal of Pharmaceutics and Biopharmaceutics,2013,85:550-559.

Study on Distribution of CD3⁺ Lymphocytes in Cattle Respiratory Tract

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	ZHANG Dianqi, MA Xinhao, YANG Zhimei, MEI Chugang, ZAN Linsen. Bioinformatics Analysis of PAI1 Gene and Its Effect on the Proliferation and Differentiation of Intramuscular Adipocytes in Qinchuan Beef Cattle [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1729-1741.
[2]	PENG Yangxiang, YANG Zhenbiao, YAN Kuiyou, WANG Han, HU De, WANG Zun, LIU Ning, ZHAO Liansheng. From Artificial to Intelligent:Research Progress of Individual Idendification Technology for Cattle [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1855-1866.
[3]	LI Mingbo, GAO Qingshan, LI Guanhao, ZHANG Kui, CUI Lianhua, HOU Lina. Effects of Chinese Herbal Medicine Feed Additives on Meat Quality and Flavor Substances in Yanbian Yellow Cattle [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 531-542.
[4]	SUN Haobin, XUE Yuyang, NIU Yujie, NIU Junli, ZHANG Wenju, CHEN Cheng. Effects of Whole Triticale Hay on Nutrient Apparent Digestibility,Serum Biochemical Indices and Rumen Fermentation of Breeding Cattle [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 106-114.
[5]	TAN Haoyun, LIU Qian, HU Debao, ZHANG Linlin, LI Xin, DING Xiangbin, GUO Hong, GUO Yiwen. Effects of Interference lnc721 on Proliferation and Differentiation of Bovine Skeletal Muscle Satellite Cells [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3292-3300.
[6]	XU Haoqi, XU Jingyi, HU Lirong, ZHANG Fan, LUO Hanpeng, ZHANG Hailiang, SHI Rui, LI Xiang, LIU Lin, LIU Qiaoxiang, GUO Gang, WANG Yachun. Polymorphism of PIK3CB Gene and Its Association Analysis with Reproductive and Milk Production Traits in Chinese Holstein Cattle [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3438-3452.
[7]	YANG Min, GAO Yu, XU Zihao, ZHANG Jiulong, DELINUER·Baishanbieke, REN Wanping. Effects of Feeding Steam-flaked Corn on Weight Gain,Rumen Fermentation and Microbial Diversity of Xinjiang Brown cattle [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 2961-2970.
[8]	REN Jianming, JI Peng, ZHANG Xiaosong, WEI Yanming, ZHU Xiaopeng, ZHU Yueming. Effects of Jianpi Xiaodao Chinese Herbal Compound on Growth Performance, Rumen Fermentation Parameters and Serum Indexes of 6-month-old Simmental Crossbred Cattles [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2593-2600.
[9]	HE Zhanxing, HUANG Meifen, CHENG Yumei, ZHANG Quanpeng, ZHANG Jicai, YANG Kai, WANG Ankui, ZHOU Yaping, HUANG Bizhi. Comparison of Colostrum Physicochemical Characterization Between Dulong Cattle and Yunling Cattle [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2156-2164.
[10]	MA Yanru, YU Yongsheng, CAO Yang, QIN Lihong, ZHAO Yumin, WU Jian. Polymorphism of PDK4 Gene and Its Association with Meat Quality Traits in Chinese Steppe Red Cattle [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2186-2194.
[11]	SHAO Yandi, JIANG Qiufei, FENG Yuan, WANG Yu, ZHANG Juan, ZHOU Zihang, WANG Weizhen, YU Baojun, FENG Xiaofang, CHEN Yafei, GU Yaling. Research Progress on Candidate Genes of Cattle Reproductive Traits [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2270-2278.
[12]	LI Changyang, GAO Bingnan, REN Yulong, ZHANG Hao, SUN Yu, WEI Xiao, WANG Qiuju. Isolation,Identification and Biochemical Characteristics Analysis of Bovine Rumen Functional Bacteria [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1757-1764.
[13]	LI Yulong, LYU Shijie, ZHAI Yaying, ZHANG Zhijie, ZHU Xiaoting, ZHANG Zijing, CHEN Fuying, SHI Qiaoting, WANG Eryao. Cloning and Bioinformatics Analysis of POLB Gene in Jiaxian Red Cattle [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 887-896.
[14]	ZENG Yu, LIU Yao, LI Youying, PENG Zhongli, WU Huazhuo. Effects of Fermented Mixed Meal Replacing Soybean Meal in Diets on Growth Performance, Nutrient Apparent Digestibility and Serum Biochemical Indices of Beef Cattle [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 559-568.
[15]	ZHAI Yaying, SHI Qiaoting, CHU Qiuxia, ZHU Xiaoting, HUA Liushuai, ZHANG Zijing, CHEN Fuying, QI Xinglei, WANG Eryao, LYU Shijie. Differential Expression Analysis of Plasma Exosomes microRNA Between Donor and Recipient Cattle Before Embryo Transfer [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 641-649.

Study on Distribution of CD3+ Lymphocytes in Cattle Respiratory Tract

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

Study on Distribution of CD3⁺ Lymphocytes in Cattle Respiratory Tract