›› 2017, Vol. 44 ›› Issue (3): 732-739.doi: 10.16431/j.cnki.1671-7236.2017.03.016

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Effect of DEX and LPS on Growth Performance, Nutrient Metabolism,Serum Biochemical Indexes and Intestinal Morphology Development of Broiler Chickens

FENG Yan1, ZHANG Fen-que2,3, XUE Zhi-quan1, FAN Xin-feng1, ZHANG Jin-qiang2, LI Jian-hui2   

  1. 1. College of Life Science, Shanxi Agricultural University, Taigu 030801, China;
    2. College of Animal Science and Technology, Shanxi Agricultural University, Taigu 030801, China;
    3. Animal Husbandry Technology Promotion Center of Weinan City, Weinan 714000, China
  • Revised:2016-05-03 Online:2017-03-20 Published:2017-03-21

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Abstract:

This research was to study the effect of bacterial lipopolysaccharide (LPX) and dexamethasone (DEX) on the growth performance,nutrient metabolism and blood biochemical indexes and intestinal morphology development of broiler chickens. 224 AA broilers with similar body weight and 1-day-old were chosen and divided into 4 groups randomly,which were immune group (NV group),normal immune group (CV group),immunosuppression group (DEX group) and immune hyperthyroidism group (LPS group) with 7 replicates per group and 8 broilers per replicate. At 15,17 and 19 d,chicken of LPS and DEX groups were intramuscular injected with 500 μg/(kg·BW) LPS or 2.5 mg/(kg·BW) DEX,respectively,while chicken of NV and CV groups was injected with normal saline in the same volume. The experiment was lasted for 42 d with 7 d preliminary trial period. The results showed that the average daily feed intake (ADFI) and average daily gain (ADG) were decreased significantly (P<0.05) by LPS and DEX immunological stress,there were was no significant difference in feed to gain ratio (F/G) among experimental groups (P>0.05).The apparent metabolic rate of organic matter (DM) was no significantly affected by LPS and DEX immunological stress,while that of dry matter (OM),crude protein (CP),Ca and P were declined significantly at 36-42 d (P<0.05). At 21 and 42 d,GLU,UA and MDA levels were not significantly different among experimental groups (P>0.05).At 21 d,the contents of serum IL-6 and TNF-α in DEX and LPS groups were significantly higher than those in NV and CV groups (P<0.05),but there was no significant difference at 42 d (P>0.05).The wall thickness,mucosa thickness, villus height and the ratio of villus length to crypt depth were reduced by LPS and DEX at 21 and 42 d of broilers. In summary,LPS and DEX had an important influence on the apparent digestibility of DM,CP,Ca and P.DEX and LPS could damage the intestinal morphology of broilers,reduce the apparent metabolic rate,affect the feed intake and body weight,decrease growth performance.

Key words: broiler; LPS; DEX; growth metabolism; intestinal morphology

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