营养与表观遗传修饰关系的研究进展

doi:10.16431/j.cnki.1671-7236.2015.07.020

Abstract

Abstract: Epigenetics is a branch of genetics to study the gene expression of heritable changes when nucleotide sequence has no change.Although classical genetics theory deems that genetic DNA sequence can dominate parental gene to their offspring,growing evidence suggests that environmental factors such as nutrition play an important role in modifying genetic expression.Nutrition can affect epigenetics by DNA methylation,histone modification and microRNA (miRNA).More and more researches prove that nutrition (especially early-life nutrition) is very important to keep the body healthy.The author mainly focused on the research progress about the relationship between nutrition and epigenetic modification and its mechanism,including animal or human chronically expose on the feed condition of protein and energy deficiency,high fat,overfeeding and some especial nutrients to provide reference for the further study.

Key words: nutrition; epigenetics; mechanism; research progress

CLC Number:

Q3-05

SONG Shan-dan, CHEN Guang-ji, RAO Kai-qing, XU Ya-ou. Research Progress on Relationship between Nutrition and Epigenetic Modification[J]. , 2015, 42(7): 1755-1762.

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