Klotho蛋白在动物钙磷代谢调控中的作用

doi:10.16431/j.cnki.1671-7236.2025.06.010

摘要/Abstract

摘要： 钙和磷是动物机体中含量最丰富的两种矿物质元素，在动物机体的生长发育、新陈代谢、免疫功能等多种生命活动中发挥重要作用。钙磷代谢紊乱对动物影响显著，常引起动物营养不良和生产性能低下的症状。Klotho蛋白由抗衰老基因Klotho编码，在肾脏、脑以及骨骼中存在表达，在生物学上具有多种重要功能。研究发现，Klotho蛋白可作为辅助因子与成纤维生长因子受体(fibroblast growth factor receptor，FGFR)结合影响离子通道表达，并通过调节钙磷代谢相关激素的分泌来共同参与动物机体钙磷稳态的维持。作者综述了Klotho蛋白的表达与定位、生物学功能，以及钙磷代谢的基础过程和Klotho蛋白在钙磷代谢调控中可能机制的相关研究进展，以期为Klotho蛋白在维持机体钙磷稳态的进一步深入研究及以Klotho为潜在靶点治疗钙磷代谢疾病的开发利用提供理论参考。

关键词: Klotho蛋白; 钙磷代谢; 肾脏; 骨骼; 钙调节激素

Abstract: Calcium and phosphorus are two of the most abundant mineral elements in the animal body and play an important role in various life activities such as growth and development,metabolism,and immune function.Abnormal metabolism of calcium and phosphorus affects animals significantly,and they often cause symptoms of malnutrition and poor performance.Klotho proteins are encoded by the anti-aging gene Klotho and are expressed in kidney,brain,and bone.Klotho proteins have many important functions in biology.It was found that Klotho protein can act as a cofactor binding to fibroblast growth factor receptor (FGFR) to affect ion channel expression and regulate the secretion of hormones related to calcium and phosphorus metabolism to participate in the maintenance of calcium-phosphorus homeostasis in the animal organism.The author reviewed the expression and localization of Klotho protein, its biological functions, as well as the basic processes of calcium and phosphorus metabolism and the possible mechanisms of Klotho protein in regulating calcium and phosphorus metabolism. The paper aimed to provide theoretical references for further in-depth research on the role of Klotho protein in maintaining calcium and phosphorus homeostasis in the body, and for the development and utilization of Klotho protein as a potential target for the treatment of calcium and phosphorus metabolism diseases.

Key words: Klotho protein; calcium and phosphorus metabolism; kidney; bone; calcium regulatory hormone

中图分类号:

S852.21

吴文昊, 栾新红, 林树梅, 盖叶丹. Klotho蛋白在动物钙磷代谢调控中的作用[J]. 中国畜牧兽医, 2025, 52(6): 2561-2568.

WU Wenhao, LUAN Xinhong, LIN Shumei, GAI Yedan. Research Progress on the Role of Klotho Protein in the Regulation of Calcium and Phosphorus Metabolism in Animals[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2561-2568.

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