中国畜牧兽医 ›› 2023, Vol. 50 ›› Issue (6): 2233-2244.doi: 10.16431/j.cnki.1671-7236.2023.06.007
王静, 宋红兵, 吴艳玲, 林威敏, 肖天放
收稿日期:
2022-11-09
出版日期:
2023-06-05
发布日期:
2023-05-30
通讯作者:
肖天放
E-mail:tfxiao@163.com
作者简介:
王静,E-mail:2848049401@qq.com。
基金资助:
WANG Jing, SONG Hongbing, WU Yanling, LIN Weimin, XIAO Tianfang
Received:
2022-11-09
Online:
2023-06-05
Published:
2023-05-30
摘要: 西红花苷(crocin)作为西红花的主要生物活性化合物,有清除自由基、缓解氧化应激的能力,具备成为绿色安全抗氧化剂的潜力。西红花苷主要在肠道中分解代谢,通过血液运输至机体各部位。心脏、脾脏、肾脏和肺脏的西红花苷代谢产物较高,即在这些部位发挥其生物学作用。西红花苷为低毒物质,可用于缓解机体发生的氧化损伤。目前,西红花苷抗氧化功能多应用于缓解神经退行性疾病、抑制肿瘤生长、保护生殖系统和心脏系统。缓解氧化应激是西红花苷调控机体适应异常环境的主要方式之一,降低氧化产物产生和提高抗氧化酶活性是其主要调节手段。西红花苷可作用于多条信号通路(TLR2/NF-κB、JAK2-STAT3-ERK、Nrf2等通路),以缓解外界物质刺激所引起的机体内促氧化剂和抗氧化剂之间的失衡。作者综述了西红花苷抗氧化作用在调控动物健康中的应用以及在不同调控系统中的作用机制,为进一步深入研究西红花苷抗氧化作用机制及其调控动物健康提供理论依据;为开发新型天然抗氧化剂在疾病或机体异常中的治疗应用提供指导。
中图分类号:
王静, 宋红兵, 吴艳玲, 林威敏, 肖天放. 西红花苷在动物抗氧化作用中的研究进展[J]. 中国畜牧兽医, 2023, 50(6): 2233-2244.
WANG Jing, SONG Hongbing, WU Yanling, LIN Weimin, XIAO Tianfang. Research Progress of Crocin in Animal Antioxidants[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2233-2244.
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