中国畜牧兽医 ›› 2020, Vol. 47 ›› Issue (11): 3584-3594.doi: 10.16431/j.cnki.1671-7236.2020.11.020
白凤庭, 李林, 陈军豪, 赵蓓, 彭心雨, 王艳红, 房兴堂, 张春雷, 宋成创
收稿日期:
2020-04-26
出版日期:
2020-11-20
发布日期:
2020-11-20
通讯作者:
张春雷, 宋成创
E-mail:clzhang@jsnu.edu.cn;chengchuangsong@jsnu.edu.cn
作者简介:
白凤庭(1999-),男,江苏邳州人,本科生,研究方向:非编码RNA调控骨骼肌发育,E-mail:bft19990914@163.com
基金资助:
BAI Fengting, LI Lin, CHEN Junhao, ZHAO Bei, PENG Xinyu, WANG Yanhong, FANG Xingtang, ZHANG Chunlei, SONG Chengchuang
Received:
2020-04-26
Online:
2020-11-20
Published:
2020-11-20
摘要: 骨骼肌作为脊椎动物机体的重要组织,其胚胎期发育起始于生皮肌节的肌源性祖细胞增殖、分化成的成肌细胞,进一步发育形成肌管,最终形成肌纤维。整个发育过程受到复杂严密的调控,任何调控异常都可能影响骨骼肌正常的发育过程。近年来研究表明,除了生肌调控因子、肌细胞增强因子、配对盒因子外,非编码RNA包括微小RNA(microRNA,miRNA)、长链非编码RNA(long noncoding RNA,lncRNA)和环形RNA(circular RNA,circRNA)都可作为重要的调节因子广泛参与调控骨骼肌发育过程。其中miRNA主要作用于靶mRNA,通过诱发靶mRNA的去稳定性和/或抑制翻译,在转录后水平调控相关基因表达;lncRNA长度较长,具有高级结构,可以在转录前和转录后水平,通过多种作用方式调控相关基因表达;circRNA主要作为miRNA "海绵",竞争性结合miRNA,进而参与骨骼肌发育调控网络。作者将从骨骼肌发育、miRNA作用机制、miRNA与骨骼肌发育、lncRNA作用机制、lncRNA与骨骼肌发育、circRNA作用机制、circRNA与骨骼肌发育7个方面进行综述,以期为研究非编码RNA调控骨骼肌发育提供参考。
中图分类号:
白凤庭, 李林, 陈军豪, 赵蓓, 彭心雨, 王艳红, 房兴堂, 张春雷, 宋成创. 非编码RNA与骨骼肌发育研究进展[J]. 中国畜牧兽医, 2020, 47(11): 3584-3594.
BAI Fengting, LI Lin, CHEN Junhao, ZHAO Bei, PENG Xinyu, WANG Yanhong, FANG Xingtang, ZHANG Chunlei, SONG Chengchuang. Research Progress on Non-coding RNA and Skeletal Muscle Development[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(11): 3584-3594.
[1] HORAK M,NOVAK J,BIENERTOVA-VASKU J.Muscle-specific microRNAs in skeletal muscle develop-ment[J].Developmental Biology,2016,410(1):1-13. [2] MOLKENTIN J D,FIRULLI A B,BLACK B L,et al.MEF2B is a potent transactivator expressed in early myogenic lineages[J].Molecular and Cellular Biology,1996,16(7):3814-3824. [3] MOLKENTIN J D,BLACK B L,MARTIN J F,et al.Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins[J].Cell,1995,83(7):1125-1136. [4] RELAIX F,ROCANCOURT D,MANSOURI A,et al.A Pax3/Pax7-dependent population of skeletal muscle progenitor cells[J].Nature,2005,435(7044):948-953. [5] DE RIE D,ABUGESSAISA I,ALAM T,et al.An integrated expression atlas of miRNAs and their promoters in human and mouse[J].Nature Biotechnology,2017,35(9):872-878. [6] DUCHAINE T F,FABIAN M R.Mechanistic insights into microRNA-mediated gene silencing[J].Cold Spring Harb Perspect Biology,2019,11(3):a032771. [7] MOHR A,MOTT J.Overview of microRNA biology[J].Seminars in Liver Disease,2015,35(1):3-11. [8] JO M H,SHIN S,JUNG S-R,et al.Human argonaute 2 has diverse reaction pathways on target RNAs[J].Molecular Cell,2015,59(1):117-124. [9] DYKES I M,EMANUELI C.Transcriptional and post-transcriptional gene regulation by long non-coding RNA[J].Genomics Proteomics Bioinformatics,2017,15(3):177-186. [10] MA L N,BAJIC V B,ZHANG Z.On the classification of long non-coding RNAs[J].RNA Biology,2013,10(6):925-933. [11] BI P,RAMIREZ-MARTINEZ A,LI H,et al.Control of muscle formation by the fusogenic micropeptide myomixer[J].Science,2017,356(6335):323-327. [12] KRISTENSEN L S,ANDERSEN M S,STAGSTED L V W,et al.The biogenesis,biology and characterization of circular RNAs[J].Nature Reviews Genetics,2019,20(11):675-691. [13] 齐玉涵,刘泽鹏,张伟杰,等.环形RNA研究进展[J].生理学报,2019,71(4):613-624. QI Y H,LIU Z P,ZHANG W J,et al.Research advance in circular RNAs[J].Acta Physiologica Sinica,2019,71(4):613-624.(in Chinese) [14] LI Z Y,HUANG C,BAO C,et al.Exon-intron circular RNAs regulate transcription in the nucleus[J].Nature Structural & Molecular Biology,2015,22(3):256-264. [15] CHEN N F,ZHAO G,YAN X,et al.A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1[J].Genome Biology,2018,19(1):218. [16] CONN V M,HUGOUVIEUX V,NAYAK A,et al.A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation[J].Nature Plant,2017,3:17053. [17] LI X,YANG L,CHEN L L.The biogenesis,functions,and challenges of circular RNAs[J].Molecular Cell,2018,71(3):428-442. [18] THOMSDN D W,DINGER M E.Endogenous microRNA sponges:Evidence and controversy[J].Nature Reviews Genetics,2016,17(5):272-283. [19] SIRACUSA J,KOULMANN N,BANZET S.Circulating myomiRs:A new class of biomarkers to monitor skeletal muscle in physiology and medicine[J].Journal of Cachexia,Sarcopenia and Muscle,2018,9(1):20-27. [20] CHEN J F,MANDEL E M,THOMSON J M,et al.The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation[J].Nature Genetics,2005,38(2):228-233. [21] WINBANKS C E,WANG B,BEYER C,et al.TGF-β regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4[J].The Journal of Biological Chemistry,2011,286(16):13805-13814. [22] SUN Y T,GE Y J,DRNEVICH J,et al.Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis[J].The Journal of Cell Biology,2010,189(7):1157-1169. [23] GOLJANEK-WHYSALL K,SWEETMAN D,ABU-ELMAGD M,et al.microRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(29):11936-11941. [24] WANG D Z,XIAO X,YAN Z,et al.microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7[J].Journal of Cell Biology,2010,190(5):867-879. [25] BJORNSON C R,CHEUNG T H,LIU L,et al.Notch signaling is necessary to maintain quiescence in adult muscle stem cells[J].Stem Cells,2012,30(2):232-242. [26] GAGAN J,DEY B K,LAYER R,et al.Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1_206 microRNAs in differentiating myoblasts[J].Journal of Biological Chemistry,2012,287(48):40360-40370. [27] GOLJANEK-WHYSALL K,MOK G F,FAHAD A A,et al.MyomiR-dependent switching of BAF60 variant incorporation into Brg1 chromatin remodeling complexes during embryo myogenesis[J].Development,2014,141(17):3378-3387. [28] FENG Y,NIU L L,WEI W,et al.A feedback circuit between miR-133 and the ERK1/2 pathway involving an exquisite mechanism for regulating myoblast proliferation and differentiation[J].Cell Death and Disease,2013,4:e934. [29] MOK G F,LOZANO-VELASCO E,MANIOU E,et al.miR-133-mediated regulation of the Hedgehog pathway orchestrates embryo myogenesis[J].Development,2018,145(12):dev159657. [30] DEY B K,GAGAN J,DUTTA A,et al.miR-206 and -486 induce myoblast differentiation by downregulating Pax7[J].Molecular and Cellular Biology,2011,31(1):203-214. [31] SMALL E M,O'ROURKE J R,MORESI V,et al.Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(9):4218-4223. [32] CAI B L,MA M T,CHEN B,et al.miR-16-5p targets SESN1 to regulate the p53 signaling pathway,affecting myoblast proliferation and apoptosis,and is involved in myoblast differentiation[J].Cell Death & Disease,2018,9(3):367. [33] SONG C C,YANG Z X,DONG D,et al.miR-483 inhibits bovine myoblast cell proliferation and differentiation via IGF1/PI3K/AKT signal pathway[J].Journal of Cellular Physiology,2019,234(6):9839-9848. [34] KONG D L,HE M,YANG L,et al.miR-17 and miR-19 cooperatively promote skeletal muscle cell differentia-tion[J].Cellular and Molecular Life Sciences,2019,76(24):5041-5054. [35] GE G H,YANG D L,TAN Y,et al.miR-10b-5p regulates C2C12 myoblasts proliferation and differentiation[J].Bioscience,Biotechnology,and Biochemistry,2019,83(2):291-299. [36] WANG H,ZHANG Q,WANG B B,et al.miR-22 regulates C2C12 myoblast proliferation and differentiation by targeting TGFBR1[J].European Journal of Cell Biology,2018,97(4):257-268. [37] YIN H D,HE H R,SHEN X X,et al.miR-9-5p inhibits skeletal muscle satellite cell proliferation and differentiation by targeting IGF2BP3 through the IGF2-PI3K/Akt signaling pathway[J].International Journal of Molecular Sciences,2020,21(5):1655. [38] HOU L J,XU J,JIAO Y R,et al.miR-27b promotes muscle development by inhibiting MDFI expression[J].Cellular Physiologyand Biochemistry,2018,46(6):2271-2283. [39] IBRAHIM E E,DONG D,WANG X,et al.Bta-miR-885 promotes proliferation and inhibits differentiation of myoblasts by targeting MyoD1[J].Journal of Cellular Physiology,2020,Online ahead of print. [40] DU J J,ZHANG P W,ZHAO X,et al.microRNA-351-5p mediates skeletal myogenesis by directly targeting lactamase-β and is regulated by lnc-mg[J].The FASEB Journal,2019,33(2):1911-1926. [41] GE J,ZHU J Y,XIA B,et al.miR-423-5p inhibits myoblast proliferation and differentiation by targeting Sufu[J].Journal of Cellular Biochemistry,2018,119(9):7610-7620. [42] QIN J,SUN Y M,LIU S G,et al.microRNA-323-3p promotes myogenesis by targeting Smad2[J].Journal of Cellular Biochemistry,2019,120(11):18751-18761. [43] WU J Y,YUE B L,LAN X Y,et al.miR-499 regulates myoblast proliferation and differentiation by targeting transforming growth factor β receptor 1[J].Journal of Cellular Physiology,2019,234(3):2523-2536. [44] WANG J,SONG C C,CAO X K,et al.miR-208b regulates cell cycle and promotes skeletal muscle cell proliferation by targeting CDKN1A[J].Journal of Cellular Physiology,2019,234(4):3720-3729. [45] WANG J,TAN J Y,QI Q,et al.miR-487b-3p suppresses the proliferation and differentiation of myoblasts by targeting IRS1 in skeletal muscle myogenesis[J].International Journal of Biological Sciences,2018,14(7):760-774. [46] HOU L J,ZHU L H,LI H Q,et al.miR-501-3p forms a feedback loop with FOS,MDFI,and MyoD to regulate C2C12 myogenesis[J].Cells,2019,8(6):573. [47] LU Z K,DU L X,LIU R Z,et al.miR-378 and BMP-Smad can influence the proliferation of sheep myoblast[J].Gene,2018,674:143-150. [48] GAN M L,DU J J,SHEN L Y,et al.miR-152 regulates the proliferation and differentiation of C2C12 myoblasts by targeting E2F3[J].In Vitro Cellular & Developmental Biology Animal,2018,54(4):304-310. [49] CAI R,NAREN Q,MA M L,et al.Wnt1 microRNA-664-5p promotes myoblast proliferation and inhibits myoblast differentiation by targeting serum response factor and Wnt1[J].The Journal of Biological Chemistry,2018,293(50):19177-19190. [50] YUAN R Q,ZHANG X M,FANG Y,et al.miR-127-3p inhibits the proliferation of myocytes by targeting KMT5a[J].Biochemical and Biophysical Research Communications,2018,503(2):970-976. [51] HUANG W L,GUO L J,ZHAO M X,et al.The inhibition on MDFIC and PI3K/AKT pathway caused by miR-146b-3p triggers suppression of myoblast proliferation and differentiation and promotion of apoptosis[J].Cells,2019,8(7):656. [52] HU X,XING Y S,REN L,et al.ACVR1BBta-miR-24-3p controls the myogenic differentiation and proliferation of fetal,bovine,skeletal muscle-derived progenitor cells by targeting[J].Animals:An Open Access Journal from MDPI,2019,9(11):859. [53] LI X,ZHU Y B,ZHANG H F,et al.microRNA-106a-5p inhibited C2C12 myogenesis via targeting PIK3R1 and modulating the PI3K/AKT signaling[J].Genes,2018,9(7):333. [54] LING Y H,SUI M H,ZHENG Q,et al.miR-27b regulates myogenic proliferation and differentiation by targeting Pax3 in goat[J].Scientific Reports,2018,8(1):3909. [55] WANG Z J,ZHANG X C,LI Z H,et al.miR-34b-5p mediates the proliferation and differentiation of myo-blasts by targeting IGFBP2[J].Cells,2019,8(4):360. [56] YANG Z X,SONG C C,JIANG R,et al.micro-ribonucleic acid-216a regulates bovine primary muscle cells proliferation and differentiation via targeting SMAD nuclear interacting protein-1 and Smad7[J].Frontiers in Genetics,2019,10:1112. [57] ZHOU S,LI S,ZHANG W W,et al.miR-139 promotes differentiation of bovine skeletal muscle-derived satellite cells by regulating DHFR gene expression[J].Journal of Cell Physiology,2018,234(1):632-641. [58] ZHU L H,HOU L J,OU J X,et al.miR-199b represses porcine muscle satellite cells proliferation by targeting JAG1[J].Gene,2019,691:24-33. [59] YU X H,ZHANG Y,LI T T,et al.Long non-coding RNA linc-RAM enhances myogenic differentiation by interacting with MyoD[J].Nature Communications,2017,8:14016. [60] CARETTI G,LOUIS SCHILJZ R,JEFFREY DILWORTH F,et al.The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation[J].Developmental Cell,2006,11(4):547-560. [61] MOUSAVI K,ZARE H,DELL'ORSO S,et al.eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci[J].Molecular Cell,2013,51(5):606-617. [62] WANG L J,ZHAO Y,BAO X C,et al.lncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration[J].Cell Research,2015,25(3):335-350. [63] JIN J J,LV W,XIA P,et al.Long noncoding RNA SYISL regulates myogenesis by interacting with polycomb repressive complex 2[J].Proceedings of the National Academy of Sciences of the United States of America,2018,115(42):E9802-E9811. [64] WANG S S,ZUO H,JIN J J,et al.Long noncoding RNA Neat1 modulates myogenesis by recruiting Ezh2[J].Cell Death & Disease,2019,10(7):505. [65] KANG X D,ZHAO Y,ARSDELL G V,et al.Ppp1r1b-lncRNA inhibits PRC2 at myogenic regulatory genes to promote cardiac and skeletal muscle development in mouse and human[J].RNA (New York,N.Y.),2020,26(4):481-491. [66] CHEN X N,HE L Q,ZHAO Y,et al.Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity[J].Cell Discovery,2017,3:17002. [67] ZHOU Y L,CHEUNSUCHON P,NAKAYAMA Y,et al.Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene[J].Development,2010,137(16):2643-2652. [68] ZHAO J,OHSUMI T K,KUNG J T,et al.Genome-wide identification of polycomb-associated RNAs by RIP-seq[J].Molecular Cell,2010,40(6):939-953. [69] ZHOU L,SUN K,ZHAO Y,et al.Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1[J].Nature Communications,2015,6:10026. [70] MILITELLO G,HOSEN M R,PONOMAREVA Y,et al.A novel long non-coding RNA myolinc regulates myogenesis through TDP-43 and Filip1[J].Journal of Molecular Cell Biology,2018,10(2):102-117. [71] HITACHI K,NAKATANI M,TAKASAKI A,et al.Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation[J].EMBO Report,2019,20(3):e47468. [72] SUI Y T,HAN Y,ZHAO X Y,et al.Long non-coding RNA Irm enhances myogenic differentiation by interacting with MEF2D[J].Cell Death & Disease,2019,10(3):181. [73] KALLEN A N,ZHOU X B,XU J,et al.The imprinted H19 lncRNA antagonizes let-7 microRNAs[J].Molecular Cell,2013,52(1):101-112. [74] CESANA M,CACCHIARELLI D,LEGNINI I,et al.A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA[J].Cell,2011,147(2):358-369. [75] ZHANG Z K,LI J,GUAN D G,et al.A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration[J].Journal of Cachexia, Sarcopenia Muscle,2018,9(3):613-626. [76] ZHU M,LIU J F,XIAO J,et al.lnc-mg is a long non-coding RNA that promotes myogenesis[J].Nature Communications,2017,8:14718. [77] SONG C C,WANG J,MA Y L,et al.Linc-smad7 promotes myoblast differentiation and muscle regeneration via sponging miR-125b[J].Epigenetics,2018,13(6):591-604. [78] ZHANG Z K,LI J,GUAN D G,et al.Long non-coding RNA lncMUMA reverses established skeletal muscle atrophy following mechanical unloading[J].Molecular Therapy,2018,26(11):2669-2680. [79] LI H,YANG J M,JIANG R,et al.Long non-coding RNA profiling reveals an abundant MDNCR that promotes differentiation of myoblasts by sponging miR-133a[J].Molecular Therapy Nucleic Acids,2018,12:610-625. [80] WANG G Q,WANG Y,XIONG Y,et al.Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a[J].Scientific Reports,2016,6:21865. [81] LIANG T T,ZHOU B,SHI L,et al.lncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c[J].The FASEB Journal,2017,32(1):377-389. [82] HAN X R,YANG F,CAO H Q,et al.Malat1 regulates serum response factor through miR-133 as a competing endogenous RNA in myogenesis[J].The FASEB Journal,2015,29(7):3054-3064. [83] LU L N,SUN K,CHEN X N,et al.Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis[J].The EMBO Journal,2013,32(19):2575-2588. [84] GONG C G,LI Z Z,RAMANUJAN K,et al.A long non-coding RNA,lncMyoD,regulates skeletal muscle differentiation by blocking IMP2-mediated mRNA transla-tion[J].Developmental Cell,2015,34(2):181-191. [85] ZHANG Q,VASHISHT A A,O'ROURKE J,et al.The microprotein minion controls cell fusion and muscle formation[J].Nature Communications,2017,8:15664. [86] QUINN M E,GOH Q,KUROSAKA M,et al.Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development[J].Nature Communications,2017,8:15665. [87] OUYANG H J,CHEN X L,LI W M,et al.Circular RNA circSVIL promotes myoblast proliferation and differentiation by sponging miR-203 in chicken[J].Frontiers in Genetics,2018,9:172. [88] CHEN X L,OUYANG H J,WANG Z J,et al.A novel circular RNA generated by FGFR2 gene promotes myoblast proliferation and differentiation by sponging miR-133a-5p and miR-29b-1-5p[J].Cells,2018,7(11):199. [89] CHEN B,YU J,GUO L J,et al.Circular RNA circHIPK3 promotes the proliferation and differentiation of chicken myoblast cells by sponging miR-30a-3p[J].Cells,2019,8(2):177. [90] WANG X G,CAO X K,DONG D,et al.Circular RNA TTN acts as a miR-432 sponge to facilitate proliferation and differentiation of myoblasts via the IGF2/PI3K/AKT signaling pathway[J].Molecular Therapy Nucleic Acids,2019,18:966-980. [91] YUE B L,WANG J,RU W X,et al.The circular RNA circHUWE1 sponges the miR-29b-AKT3 axis to regulate myoblast development[J].Molecular Therapy Nucleic Acids,2020,19:1086-1097. [92] LI H,YANG J M,WEI X F,et al.circFUT10 reduces proliferation and facilitates differentiation of myoblasts by sponging miR-133a[J].Journal of Cell Physiology,2018,233(6):4643-4651. [93] LI X Y,LI C Y,LIU Z J,et al.Circular RNA circ-FoxO3 inhibits myoblast cells differentiation[J].Cells,2019,8(6):616. [94] PENG S J,SONG C C,LI H,et al.Circular RNA SNX29 sponges miR-744 to regulate proliferation and differentiation of myoblasts by activating the Wnt5a/Ca2+signaling pathway[J].Molecular Therapy. Nucleic Acids,2019,16:481-493. [95] WEI X F,LI H,YANG J M,et al.Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p[J].Cell Death & Disease,2017,8(10):e3153. [96] LI H,WEI X F,YANG J M,et al.circFGFR4 promotes differentiation of myoblasts via binding miR-107 to relieve its inhibition of Wnt3a[J].Molecular Therapy Nucleic Acids,2018,11:272-283. [97] WANG Y H,LI M L,WANG Y H,et al.A Zfp609 circular RNA regulates myoblast differentiation by sponging miR-194-5p[J].International Journal of Biological Macromolecules,2019,121:1308-1313. [98] LI L,CHEN Y,NIE L,et al.MyoD-induced circular RNA CDR1as promotes myogenic differentiation of skeletal muscle satellite cells[J].Biochimica et Biophysica Acta.Gene Regulatory Mechanisms,2019,1862(8):807-821. [99] OUYANG H J,CHEN X L,WANG Z J,et al.Circular RNAs are abundant and dynamically expressed during embryonic muscle development in chickens[J].DNA Research:An International Journal for Rapid Publication of Reports on Genes and Genomes,2018,25(1):71-86. |
[1] | 李洁, 陈楚雯, 赵瑞鹏, 刘媛, 李志雄. lncRNA在畜禽肌肉发育中的研究进展[J]. 中国畜牧兽医, 2023, 50(6): 2427-2438. |
[2] | 余鹏, 牛晓玉, 董翎, 陆梦琪, 陈燕虹, 李凡, 宋卉. lncRNA在猪流产相关病毒感染中的作用研究进展[J]. 中国畜牧兽医, 2022, 49(9): 3559-3568. |
[3] | 薛倩, 李国辉, 邢伟杰, 周成浩, 张会永, 殷建玫, 朱云芬, 曹愉夏, 苏一军, 韩威. 鸡繁殖性状近交衰退相关lncRNA的筛选[J]. 中国畜牧兽医, 2022, 49(6): 2176-2185. |
[4] | 王梓行, 邓兴梅, 邱润辉, 朱德馨, 李佳, 陶婷婷, 朱嘉乐, 孙志华, 张辉. 长链非编码RNA在PEDV感染Vero-E6细胞中对自噬的调控作用[J]. 中国畜牧兽医, 2022, 49(5): 1942-1950. |
[5] | 马程, 胡文萍, 石田培, 侯浩宾, 李海静, 张新浩, 杨莉, 张莉. 乌头驴与三粉驴骨骼肌中miRNAs的表达鉴定与分析[J]. 中国畜牧兽医, 2021, 48(6): 1894-1905. |
[6] | 丁浩, 林月月, 张涛, 张闪闪, 吴玉麟, 段严军, 巩用双, 谢恺舟, 王金玉, 戴国俊, 张跟喜. m6A甲基化在鸡肌肉生长发育中的表达研究[J]. 中国畜牧兽医, 2021, 48(5): 1525-1534. |
[7] | 李培, 刘国梅, 刘迎迎, 刘曼迪, 李妍, 范京惠. 产肠毒素大肠杆菌F41感染猪小肠上皮细胞初期lncRNA的表达谱分析[J]. 中国畜牧兽医, 2021, 48(5): 1707-1716. |
[8] | 林泽堃, 庄晓娜, 罗君谊, 陈婷, 习欠云, 张永亮, 孙加节. 非编码RNA对猪骨骼肌发育的影响[J]. 中国畜牧兽医, 2021, 48(10): 3595-3603. |
[9] | 刘梦馨, 杜双杨, 杨京沧, 黄娴雅, 郭宇兵, 李滢硕, 郭凯军, 曹素英. lncRNA作为竞争性内源分子的作用机制及研究进展[J]. 中国畜牧兽医, 2021, 48(10): 3604-3613. |
[10] | 郭东光, 陈明艳, 崔芳微, 李文明, 郭赞莹, 朱艳平, 岳锋, 王选年. 胸腺上皮细胞中雌激素诱导lncRNA的鉴定分析及表达载体构建[J]. 中国畜牧兽医, 2021, 48(1): 64-71. |
[11] | 张珈溯, 夏广军, 尹宝珍, 张洛萌, 邵静, 耿春银. 外泌体长链非编码RNA对脂代谢调控机制的研究进展[J]. 中国畜牧兽医, 2020, 47(4): 1028-1034. |
[12] | 贾纯琰, 季小阳, 白雪, 戴豪扬, 王建蒙, 张文广. 长链非编码RNA的调控机制及其在家畜中的预测方法[J]. 《中国畜牧兽医》, 2017, 44(7): 1895-1905. |
[13] | 顾真真, 李红, 刘乙, 谭文波, 任俊晓, 李艳敏, 李转见, 田亚东, 刘小军. lncLER在卢氏绿壳蛋鸡肝脏中表达调控的研究[J]. 《中国畜牧兽医》, 2017, 44(4): 973-979. |
[14] | 陆启荣, 刘孟轲, 李丽, 程古月, 郝海红, 王旭, 戴梦红, 袁宗辉. 畜禽长链非编码RNA的功能及其研究方法[J]. 《中国畜牧兽医》, 2016, 43(9): 2425-2434. |
[15] | 苏晓娜, 谢靑梅, 陈峰. 长链非编码RNA及其在畜禽生长调控中的研究进展[J]. , 2016, 43(1): 197-203. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||