非编码RNA对猪骨骼肌发育的影响

doi:10.16431/j.cnki.1671-7236.2021.10.010

摘要/Abstract

摘要： 骨骼肌发育与猪肉产量和品质密切相关，且受到各种因素的影响。近年来，非编码RNA （non-coding RNA，ncRNA）对骨骼肌发育的影响已成为新的研究热点之一。ncRNA主要包括微小RNA （microRNA，miRNA）、长链非编码RNA （long non-coding RNA，lncRNA）和环状RNA （circular RNA，circRNA），是一类不具有编码蛋白功能的RNA，最初被认为只是在转录或转录后水平调控基因的表达，但随着研究的深入，越来越多的ncRNA被证实参与骨骼肌细胞增殖、分化与凋亡等生物过程，其中miRNA可通过与靶基因互补序列结合发挥功能；lncRNA与circRNA主要作为分子海绵竞争性结合miRNA，解除其对靶基因的抑制作用。作者主要从ncRNA介绍及miRNA、lncRNA和circRNA对猪骨骼肌发育的影响等进行综述，并就ncRNA对猪骨骼肌生长发育的研究进行了展望。

关键词: 非编码RNA; 猪; 骨骼肌发育; 微小RNA; 长链非编码RNA; 环状RNA

Abstract: Skeletal muscle development is closely related to pork yield and quality, which is affected by various factors. In recent years, the influence of non-coding RNA (ncRNA) on skeletal muscle development has become one of the new research hotspot. ncRNA mainly include microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA), which were a class of RNAs that do not have the function of encoding a protein. Initially, they were thought to only regulate gene expression at the transcriptional and post-transcriptional level. However, with the deepening of research, more and more non-coding RNAs have been confirmed to be involved in various biological processes, such as proliferation, differentiation and apoptosis of skeletal muscle cells. In details, miRNAs affect the function of the targeted mRNAs by binding to the complementary sequences of their target mRNA. lncRNA and circRNA can act as molecular sponges of miRNA to weaken the inhibitory effect of miRNA on targets. Therefore, the author mainly reviews ncRNA introduction, and the effects of miRNA, lncRNA and circRNA on the development of porcine skeletal muscle, and put forward the prospect of ncRNA on the growth and development of porcine skeletal muscle.

Key words: ncRNA; pigs; skeletal muscle development; miRNA; lncRNA; circRNA

中图分类号:

Q752

林泽堃, 庄晓娜, 罗君谊, 陈婷, 习欠云, 张永亮, 孙加节. 非编码RNA对猪骨骼肌发育的影响[J]. 中国畜牧兽医, 2021, 48(10): 3595-3603.

LIN Zekun, ZHUANG Xiaona, LUO Junyi, CHEN Ting, XI Qianyun, ZHANG Yongliang, SUN Jiajie. Effects of Non-coding RNAs on Skeletal Muscle Development in Pigs[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(10): 3595-3603.

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