猪源沙门菌的耐药现状、检测方法与防治技术研究进展

doi:10.16431/j.cnki.1671-7236.2023.12.034

摘要/Abstract

摘要： 猪源沙门菌是一种人兽共患病原体,可引起仔猪的急性全身性感染,严重阻碍养殖业的发展。猪源沙门菌可通过食物链传播给人,对公共卫生安全造成潜在威胁。人们在生产上常用抗菌药物对猪源沙门菌进行控制,但抗菌药物的广泛使用导致沙门菌的耐药性不断增强,耐药谱不断扩大,增加了对该菌的防治难度。随着细菌检测技术的不断发展和对沙门菌研究的深入,低成本、操作简单、特异性强的检测方法不断被开发应用,为沙门菌的检测提供了技术支持。疫苗免疫是预防猪感染沙门菌的重要手段之一,目前市面上的疫苗主要是减毒活疫苗,具有免疫原性好、保护力持久等优点,而灭活疫苗和基因工程苗也在开发研制中。除抗菌药物能对沙门菌有治疗和控制效果外,中药制剂和微生态药物对沙门菌也有很好的抑制作用,被认为是很好的替抗产品,具有良好的开发和应用前景。笔者对猪源沙门菌的耐药现状进行阐述,并对猪源沙门菌的检测方法和防治技术研究进展进行归纳和总结,以期为猪源沙门菌的预防与控制提供新的思路。

关键词: 猪源沙门菌; 耐药性; 检测方法; 防治技术

Abstract: Swine Salmonella is a zoonotic pathogen that can cause acute systemic infections in young pigs,seriously hindering the development of the breeding industry.Swine Salmonella can be transmitted to humans through the food chain,posing a potential threat to public health.Antibiotics are commonly used to control swine Salmonella in production,but the widespread use of antibiotics has led to the continuous enhancement of its resistance and the expansion of its resistance spectrum,increasing the difficulty of prevention and control.With the continuous development of bacteria detection technology and in-depth research on Salmonella,low-cost,simple and specific detection methods have been developed and applied,providing technical support for the detection of Salmonella.Vaccine immunization is one of the important means to prevent swine Salmonella.Currently,the vaccines on the market are mainly live attenuated vaccines,which have the advantages of good immunogenicity and durable protection,and inactivated vaccines and genetic engineering vaccines are also under development.In addition to antibiotics for the treatment and control of Salmonella,traditional Chinese medicine preparations and micro-ecological drugs also have good inhibitory effects on Salmonella,and are considered to be good substitute products with good development and application prospects.In this paper,the current situation of drug resistance of swine Salmonella was described,and the research progress of detection methods and control technologies of swine Salmonella was summarized,in order to provide theoretical basis and new ideas for the prevention and control of swine Salmonella.

Key words: swine Salmonella; drug resistance; detection methods; prevention and control technologies

中图分类号:

S852.61

何振文, 刘丁语, 刘宝玲, 陈天宝, 王刚, 王晓虎, 刘文俊, 蔡汝健. 猪源沙门菌的耐药现状、检测方法与防治技术研究进展[J]. 中国畜牧兽医, 2023, 50(12): 5123-5135.

HE Zhenwen, LIU Dingyu, LIU Baoling, CHEN Tianbao, WANG Gang, WANG Xiaohu, LIU Wenjun, CAI Rujian. Research Progress on Drug Resistance, Detection Methods and Prevention and Control Technologies of Swine Salmonella[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(12): 5123-5135.

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