环肽pLR的生物学活性研究进展

摘要/Abstract

摘要： 环肽pLR(LVRGCWTKSYPPKPCFVR)是以2个半胱氨酸的二硫键成环,不仅具有类胰蛋白酶抑制剂的典型分子结构特点,且具有促肥大细胞释放组胺,抑制类胰蛋白酶活性和粒细胞—巨噬细胞集落形成,对电负性POPG膜有透化作用,但无溶血作用,并对过敏性哮喘小鼠模型的表现型症状和肺脏组织损伤具有治疗作用。作者针对环肽pLR的结构与功能、生物学活性及在哮喘动物模型中的免疫调节作用进行了综述,以期为环肽类药物的开发和应用提供参考。

关键词: 环肽pLR; 生物学活性; 胰蛋白酶抑制剂; 免疫调节

Abstract: A cyoclopolypeptide named pLR possesses an amino acid sequence as LVRGCWTKSYPPKPCFVR and a S-S bridge between two cysteines and characteristic features of typical tryptase inhibitor conformation.Cyoclopolypeptide pLR shows strong activation in the histamine release of mast cells,inhibition in tryptase and the early development of granulocyte macrophage colonies,permeabilization of negatively charged POPG vesicle,but inactivity in hemolysis.Cyoclopolypeptide pLR significantly decreases the phenotypes and lung tissue injury in asthma models.The authors reviewed the structure and function,biological activity of cyclopolypeptide pLR and its immunological regulation in asthma models,which is helpful for the development and application of cyclopolypeptide medicine.

Key words: cyclopolypeptide pLR; biological activity; tryptase inhibitor; immunological regulation

中图分类号:

Q516

刘宁, 林霖, 王建平. 环肽pLR的生物学活性研究进展[J]. , 2014, 41(10): 134-138.

LIU Ning, LIN Lin, WANG Jian-ping. Research Progress on Biological Activity of Cyclopolypeptide pLR[J]. , 2014, 41(10): 134-138.

参考文献

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