哺乳动物胚胎的活性氧来源及其抗氧化机制

摘要/Abstract

摘要： 活性氧(reactive oxygen species, ROS)与胚胎发育缺陷密切相关,胚胎或其培养的环境都有可能产生ROS,一些外源因子能够使胚胎的ROS产量增加,引起胚胎发育阻滞,这严重地限制了与胚胎相关的研究。胚胎存在着多种抗氧化机制,在实际操作中应结合胚胎发育各时期内部ROS的来源及其抗氧化机制,提高细胞内部抗氧化效率;控制培养条件,完善培养体系,降低外在因素对ROS的诱发作用,更高效地生产体外发育胚胎。

关键词: 胚胎; 活性氧; 来源; 抗氧化机制

Abstract: Oxidative stress is involved in the defect of embryo development, reactive oxygen species (ROS) can originate from embryo metabolism or embryo surroundings. Some exogenous factors can improve the production of ROS and cause embryo developmental arrest, it seriously limits embryos related studies. There are many mechanisms to protect embryos against ROS, therefore, it is essential to combine with ROS resources and anti-oxidative mechanisms at different developmental phase, in order to improve the inner anti-oxidative efforts, control culture conditions and in practical operation but it is a complex problem to defend oxidative damage during embryo culture, and complete culture system, decrease the induction effects of outer factors on ROS, produce in vitro embryos effectively.

Key words: embryos; ROS; sources; anti-oxidative mechanisms

中图分类号:

S814.8

庄利利, 胡德宝, 蔡丽娟, 张也, 李钟淑, 方南洙. 哺乳动物胚胎的活性氧来源及其抗氧化机制[J]. , 2013, 40(3): 173-176.

ZHUANG Li-li, HU De-bao, CAI Li-juan, ZHANG Ye, LI Zhong-shu, FANG Nan-zhu. ROS Sources and Anti-oxidative Mechanisms in Mammalian Embryos[J]. , 2013, 40(3): 173-176.

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