副流感病毒基因工程研究进展

›› 2013, Vol. ›› Issue (5): 185-189.

副流感病毒基因工程研究进展

曹丽^1,2, 师新川², 高维凡¹, 温永俊²

1. 沈阳农业大学, 辽宁沈阳 110161;
2. 中国农业科学院特产研究所, 吉林长春 130122

收稿日期:2012-10-16 出版日期:2013-05-20 发布日期:2013-05-27
通讯作者: 温永俊(1979-),男,内蒙人,博士,副研究员,从事动物分子病毒和免疫学方面的研究。Tel:0431-81919840;E-mail:yongjunwen@126.com E-mail:yongjunwen@126.com
作者简介:曹丽(1988-),女,辽宁人,硕士生,研究方向:动物分子病毒和免疫学。
基金资助:
国家863项目"新型重大动物疫病疫苗与诊断试剂创制及生产工艺创新"(2011AA10A213);吉林省特种经济动物疫病防控研究创新团队(20121823)。

Reaserch Progress on Parainfluenza Virus Genetic Engineering

CAO Li^1,2, SHI Xin-chuan², GAO Wei-fan¹, WEN Yong-jun²

1. Shenyang Agricultural University, Shenyang 110161, China;
2. Institute of Special Wild Economic Animal and Plant Science, Chinese Academy of Agricultural Sciences, Jilin 130122, China

Received:2012-10-16 Online:2013-05-20 Published:2013-05-27

摘要/Abstract

摘要： 副流感病毒是一类不分节段的单股负链RNA病毒,按基因型可分为1、2、3、4和5型,5个型之间有少量的交叉免疫,各型的生物学特性和结构类似。该病毒宿主谱广,可感染人、牛和犬等多种动物。副流感病毒具有许多优良的特性,可作为活病毒疫苗的候选载体,通过反向遗传操作系统可使其表达外源基因,研发新型疫苗。作者在综述副流感病毒病原学、基因组结构及主要蛋白质等生物学特征的基础上,着重介绍了副流感病毒作为病毒载体在基因工程方面的研究进展。

关键词: 副流感病毒; 基因; 研究进展

Abstract: The parainfluenza virus is a nonsegmented negative-strand RNA virus (NNSV),according to the genetic type, it is divided into 1,2,3,4 and 5 types, the fourth type can be divided into 4a and 4b subtypes, five types have bits of cross immunity. Biological characteristics and structures of each type are similar.The host range of parainfluenza virus is wide, it can infect human,canine,cattle and many others animal. The parainfluenza virus has a number of feature that make them attractive candidates as live virus vectors. The vectors can express foreign antigen, as a new vaccine by the reverse genetic system. This review will focus on the genetic engineering research development of parainfluenza virus as virus vectors, including antigenic, genetic structure, biological characteristics and so on.

Key words: parainfluenza viruse; gene; research progress

中图分类号:

S852.65^＋9.5

曹丽, 师新川, 高维凡, 温永俊. 副流感病毒基因工程研究进展[J]. , 2013, (5): 185-189.

CAO Li, SHI Xin-chuan, GAO Wei-fan, WEN Yong-jun. Reaserch Progress on Parainfluenza Virus Genetic Engineering[J]. , 2013, (5): 185-189.

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