microRNA的生物学功能及其在动物肌肉和脂肪组织中表达的研究进展

›› 2012, Vol. 39 ›› Issue (7): 102-107.

microRNA的生物学功能及其在动物肌肉和脂肪组织中表达的研究进展

李志娟, 高士争, 赵素梅

云南农业大学,云南省动物营养与饲料重点实验室,云南昆明 650201

收稿日期:2012-02-29 出版日期:2012-07-20 发布日期:2012-07-16
通讯作者: 赵素梅,女,河南人,博士,副教授,研究方向:动物分子营养与代谢调控。
作者简介:李志娟(1987-),女,云南人,硕士生,研究方向:动物分子营养与代谢调控。
基金资助:
国家转基因重大专项(2009ZX08009-140B);国家自然科学基金(31060331);云南省自然科学基金(2009CD056)。

Research Progress of Biological Function of MicroRNA and its Expression in Animal Muscle and Adipose Tissue

LI Zhi-juan, GAO Shi-zheng, ZHAO Su-mei

Yunnan Key Laboratory of Animal Nutrition and Feed Science, Yunnan Agricultural University, Kunming 650201, China

Received:2012-02-29 Online:2012-07-20 Published:2012-07-16

摘要/Abstract

摘要： microRNA 是一类长18~24核苷酸的短序列非编码RNA,通过抑制目的mRNA的翻译或降解,负性调控转录后基因表达。microRNA参与调控细胞增殖、死亡、神经分化、免疫调控和疾病发生等生物学过程,影响着动物的生长、发育及抗病能力。针对microRNA的特点、调控机制、分析方法及在动物肌肉和脂肪组织中的最新研究进行了综述,为利用microRNA技术对动物肌肉与脂肪相关疾病的诊断、治疗提供新的思路。

关键词: microRNA; 作用机制; 组织表达

Abstract: MicroRNA are short 18 to 24 nt non-coding RNAs, which negatively regulate post-transcriptionally gene expression. MicroRNA affect the animal growth, development and disease-resistant involving in kinds of biological process including cell proliferation, death, neuron differentiation, immune regulation and disease ontogeny and so on. Therefore, this article focuses on the characteristics, mechanism and analysis methods of microRNAs and the expression in muscle and adipose tissue. This review can supply new ways to cure the disease in muscle and adipose tissue.

Key words: microRNA; mechanism; expression of tissue

中图分类号:

李志娟, 高士争, 赵素梅. microRNA的生物学功能及其在动物肌肉和脂肪组织中表达的研究进展[J]. , 2012, 39(7): 102-107.

LI Zhi-juan, GAO Shi-zheng, ZHAO Su-mei. Research Progress of Biological Function of MicroRNA and its Expression in Animal Muscle and Adipose Tissue[J]. China Animal Husbandry & Veterinary Medicine, 2012, 39(7): 102-107.

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